University of Seville

About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.

Reactive Oxygen Intermediates, Molecular Damage, and Aging: Relation to Melatonin

Abstract: Melatonin, the chief secretory product of the pineal gland, is a direct free radical scavenger and indirect antioxidant. In terms of its scavenging activity, melatonin has been shown to quench the hydroxyl radical, superoxide anion radical, singlet oxygen, peroxyl radical, and the peroxynitrite anion. Additionally, melatonin's antioxidant actions probably derive from its stimulatory effect on superoxide dismutase, glutathione peroxidase, glutathione reductase, and glucose-6-phosphate dehydrogenase and its inhibitory action on nitric oxide synthase. Finally, melatonin acts to stabilize cell membranes, thereby making them more resistant to oxidative attack. Melatonin is devoid of prooxidant actions. In models of oxidative stress, melatonin has been shown to resist lipid peroxidation induced by paraquat, lipopolysaccharide, ischemia-reperfusion, L-cysteine, potassium cyanide, cadmium chloride, glutathione depletion, alloxan, and alcohol ingestion. Likewise, free radical damage to DNA induced by ionizing radiation, the chemical carcinogen safrole, lipopolysaccharide, and kainic acid are inhibited by melatonin. These findings illustrate that melatonin, due to its high lipid solubility and modest aqueous solubility, is able to protect macromolecules in all parts of the cell from oxidative damage. Melatonin also prevents the inhibitory action of ruthenium red at the level of the mitochondria, thereby promoting ATP production. In humans, the total antioxidative capacity of serum is related to melatonin levels. Thus, the reduction in melatonin with age may be a factor in increased oxidative damage in the elderly.

Genome-wide function of THO/TREX in active genes prevents R-loop-dependent replication obstacles.

Abstract: THO/TREX is a conserved nuclear complex that functions in mRNP biogenesis and prevents transcription-associated recombination. Whether or not it has a ubiquitous role in the genome is unknown. Chromatin immunoprecipitation (ChIP)-chip studies reveal that the Hpr1 component of THO and the Sub2 RNA-dependent ATPase have genome-wide distributions at active ORFs in yeast. In contrast to RNA polymerase II, evenly distributed from promoter to termination regions, THO and Sub2 are absent at promoters and distributed in a gradual 5′ → 3′ gradient. This is accompanied by a genome-wide impact of THO–Sub2 deletions on expression of highly expressed, long and high G+C-content genes. Importantly, ChIP-chips reveal an over-recruitment of Rrm3 in active genes in THO mutants that is reduced by RNaseH1 overexpression. Our work establishes a genome-wide function for THO–Sub2 in transcription elongation and mRNP biogenesis that function to prevent the accumulation of transcription-mediated replication obstacles, including R-loops.

Carbon capture and utilization technologies: a literature review and recent advances

Abstract: This paper presents a comprehensive list of Carbon Capture and Utilization technologies and applications, ranging from lab-scale R&D activities reported in academic papers to commercially establish...

Analysis and design of direct power control (DPC) for a three phase synchronous rectifier via output regulation subspaces

Abstract: In this paper, the authors present a controller that directly regulates the active and instantaneous reactive power in a synchronous three-phase boost-type rectifier. The controller ensures a good regulation of the output voltage, and guarantees the power factor close to one. The controller builds upon the ideas of the well known direct torque control (DTC) for induction motors. In their case, the active and reactive powers replace the torque and flux amplitude used as the controlled outputs in DTC, thus motivating the name DPC-control. They show that a simple modification to the original algorithm makes the selection of the control inputs more accurate. To formalize this technique, they utilize the concept of output regulation subspaces. A modification is added to the basic controller to deal with disturbances such as unbalance and distortion in the source voltage. Finally, the proposed controller was tested both in simulations and experimentally, and illustrative results are presented.