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Institution

University of Seville

EducationSeville, Andalucía, Spain
About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.


Papers
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Journal ArticleDOI
TL;DR: In this article, a comparative study of the antioxidant activity of wine phenolics has been performed, including benzoic and cinnamic acids, flavanols, flavonols and resveratrol.

203 citations

Journal ArticleDOI
TL;DR: In this article, an extended version of the IPAT model and the Kaya identity is used to assess the contribution of drivers of CO2 emissions for the 1995-2009 period.
Abstract: An extended version of the IPAT model and the ‘Kaya identity’ is used to assess the contribution of drivers of CO2 emissions for the 1995–2009 period. The paper carries out a multisector analysis based on the Log-Mean Divisia Index Method (LMDI I). The decomposition factors used are the Carbon Intensity factor (CI), the Energy Intensity factor (EI), the structural composition of Spain׳s economy (Economy Structure, ES), the Economic Activity factor (EA) and Population (P), respectively. Data came from the World Input–Output Database (WIOD) and determined the period under consideration. The paper focuses on the 35 productive sectors included in the WIOD. Major findings show that RES acted in detriment to the drivers of CO2 emissions. This may be stated for the last few years under consideration. The positive trend for the share of RES in Spain׳s energy matrix, together with the negative tendency in the use of fossil fuels, leads us to be optimistic.

203 citations

Journal ArticleDOI
01 Jul 2005-Small
TL;DR: The Flow Focusing platform is especially advantageous for micro-and nanoparticle production as mentioned in this paper, and it is amenable to designing the size, surface treatment and internal topology of the particles; mechanical stresses are minimal.
Abstract: The Flow Focusing platform is especially advantageous for micro- and nanoparticle production. This versatile technique is amenable to designing the size, surface treatment and internal topology of the particles; mechanical stresses are minimal—an optimal feature for the manipulation of delicate substances. Multiplexing and high-rate production are readily implemented. Adaptive operational design can lead, in one single step, to finely tuned microcapsules encasing different products within a targeted morphology. This achievement is of great significance for most microcapsule applications in the biosciences (for example, drug delivery, cell encapsulation, and the production of bead arrays).

203 citations

Journal ArticleDOI
TL;DR: The hypothesis that changes in environmental O2 tension (pO2) could affect the ionic conductances of dissociated type I cells of the carotid body was tested and low pO2 appeared to slow down the activation time course of the K current but deactivation kinetics seemed to be unaltered.
Abstract: The hypothesis that changes in environmental O2 tension (pO2) could affect the ionic conductances of dissociated type I cells of the carotid body was tested. Cells were subjected to whole-cell patch clamp and ionic currents were recorded in a control solution with normal pO2 (pO2 = 150 mmHg) and 3-5 min after exposure to the same solution with a lower pO2. Na and Ca currents were unaffected by lowering pO2 to 10 mmHg, however, in all cells studied (n = 42) exposure to hypoxia produced a reversible reduction of the K current. In 14 cells exposed to a pO2 of 10 mmHg peak K current amplitude decreased to 35 +/- 8% of the control value. The effect of low pO2 was independent of the internal Ca2+ concentration and was observed in the absence of internal exogenous nucleotides. Inhibition of K channel activity by hypoxia is a graded phenomenon and in the range between 70 and 120 mmHg, which includes normal pO2 values in arterial blood, it is directly correlated with pO2 levels. Low pO2 appeared to slow down the activation time course of the K current but deactivation kinetics seemed to be unaltered. Type I cells subjected to current clamp generate large Na- and Ca-dependent action potentials repetitively. Exposure to low pO2 produces a 4-10 mV increase in the action potential amplitude and a faster depolarization rate of pacemaker potentials, which leads to an increase in the firing frequency. Repolarization rate of individual action potentials is, however, unaffected, or slightly increased. The selective inhibition of K channel activity by low pO2 is a phenomenon without precedents in the literature that explains the chemoreceptive properties of type I cells. The nature of the interaction of molecular O2 with the K channel protein is unknown, however, it is argued that a hemoglobin-like O2 sensor, perhaps coupled to a G protein, could be involved.

202 citations

Journal ArticleDOI
TL;DR: The factors that affect the bioadhesion power of a polymer, the methods that permit the evaluation of a bioadhesive system and the methods for surface characterization of biomaterials are discussed.
Abstract: Pharmaceutical aspects of mucoadhesion have been the subject of great interest during recent years because mucoadhesion could be a solution for bioavailability problems that result from a too short length of stay of the pharmaceutical dosage form at the absorption site within the gastro-intestinal tract.This paper describes some aspects of bioadhesion such as mucus structure, stages of adhesion and the theories proposed that attempt to explain the adhesion mechanism. The factors that affect the bioadhesive power of a polymer, the methods that permit the evaluation of a bioadhesive system and the methods for surface characterization of biomaterials are discussed. Finally, the various polymers used and the bioadhesive systems designed for several therapeutic purposes are presented.

202 citations


Authors

Showing all 20465 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Aaron Dominguez1471968113224
Jose M. Ordovas123102470978
Detlef Lohse104107542787
Miroslav Krstic9595542886
María Vallet-Regí9571141641
John S. Sperry9316035602
Jose Rodriguez9380358176
Shun-ichi Amari9049540383
Michael Ortiz8746731582
Bruce J. Paster8426128661
Floyd E. Dewhirst8122942613
Joan Montaner8048922413
Francisco B. Ortega7950326069
Luis Paz-Ares7759231496
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023143
2022567
20213,357
20203,480
20193,032
20182,766