Institution
University of Seville
Education•Seville, Andalucía, Spain•
About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.
Topics: Population, Model predictive control, Control theory, Nonlinear system, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: Respiration in light and respiration in darkness are tightly coupled, with variation in respiration on leaves of an evergreen and a deciduous species accounting for more than 60% of the variation inrespiration in light.
Abstract: Dark respiration in light as well as in dark was estimated for attached leaves of an evergreen (Heteromeles arbutifolia Ait.) and a deciduous (Lepechinia fragans Greene) shrub species using an open gas-exchange system. Dark respiration in light was estimated by the Laisk method. Respiration rates in the dark were always higher than in the light, indicating that light inhibited respiration in both species. The rates of respiration in the dark were higher in the leaves of the deciduous species than in the evergreen species. However, there were no significant differences in respiration rates in light between the species. Thus, the degree of inhibition of respiration by light was greater in the deciduous species (62%) than in the evergreen species (51%). Respiration in both the light and darkness decreased with increasing leaf age. However, because respiration in the light decreased faster with leaf age than respiration in darkness, the degree of inhibition of respiration by light increased with leaf age (from 36% in the youngest leaves to 81% in the mature leaves). This suggests that the rate of dark respiration in the light is related to the rate of biosynthetic processes. Dark respiration in the light decreased with increasing light intensity. Respiration both in the light and in the dark was dependent on leaf temperature. We concluded that respiration in light and respiration in darkness are tightly coupled, with variation in respiration in darkness accounting for more than 60% of the variation in respiration in light. Care must be taken when the relation between respiration in light and respiration in darkness is studied, because the relation varies with species, leaf age, and light intensity.
187 citations
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TL;DR: A formal definition of supply chain robustness is developed to build a framework that captures the dimensions, antecedents and moderators of the construct as discussed in the literature.
Abstract: Purpose – The purpose of this paper is to provide groundwork for an emerging theory of supply chain robustness – which has been conceptualized as a dimension of supply chain resilience – through reviewing and synthesizing related yet disconnected studies. The paper develops a formal definition of supply chain robustness to build a framework that captures the dimensions, antecedents and moderators of the construct as discussed in the literature. Design/methodology/approach – The authors apply a systematic literature review approach. In order to reduce researcher bias, they involve a team of academics, librarians and managers. Findings – The paper first, provides a formal definition of supply chain robustness; second, builds a theoretical framework of supply chain robustness that augments both causal and descriptive knowledge; third,shows how findings in this review support practice; and fourth,reveals methodological insights on the use of journal rankings in reviews. Research limitations/implications – At ...
186 citations
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TL;DR: In this paper, a multiple mediation model was proposed to analyze the relationship between satisfaction and loyalty in a sample of 785 customers from 74 insurance companies in the service sector, and the results showed that perceived switching costs and the perceived lack of attractiveness of alternative offerings were significant mediators.
186 citations
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TL;DR: Observations suggest that fluctuations in the expression and the activity of critical functions of the bacterial cell, alone or combined with mutations, can contribute to adaptive resistance to antibiotics.
Abstract: Antibiotic-resistant isolates of Salmonella enterica were selected on plates containing lethal concentrations of rifampicin, kanamycin, and nalidixic acid. The stability of the resistance phenotype was scored after nonselective growth. Rifampicin-resistant (Rifr) isolates were stable, suggesting that they had arisen by mutation. Mutations in the rpoB gene were detected indeed in Rifr mutants. In contrast, a fraction of kanamycin-resistant (Kmr) and nalidixic acid-resistant (Nalr) isolates showed reduced resistance after nonselective growth, suggesting that mechanisms other than mutation had contributed to bacterial survival upon lethal selection. Single-cell analysis revealed heterogeneity in expression of the porin gene ompC, and subpopulation separation provided evidence that reduced ompC expression confers adaptive resistance to kanamycin. In the case of Nalr isolates, mutations in the gyrA gene were present in most nalidixic acid-resistant isolates. However, the efflux pump inhibitor Phe-Arg-β-naphtylamide (PAβN) reduced the level of resistance in Nalr mutants, indicating that active efflux contributes to the overall level of nalidixic acid resistance. Heterogeneous efflux pump activity was detected in single cells and colonies, and a correlation between high efflux and increased resistance to nalidixic acid was found. These observations suggest that fluctuations in the expression and the activity of critical functions of the bacterial cell, alone or combined with mutations, can contribute to adaptive resistance to antibiotics.
186 citations
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TL;DR: These early abnormalities in axonal and presynaptic structures might represent the morphological substrate of hippocampal dysfunction preceding synaptic and neuronal loss and could significantly contribute to AD pathology in the preclinical stages.
Abstract: Dystrophic neurites associated with amyloid plaques precede neuronal death and manifest early in Alzheimer’s disease (AD). In this work we have characterized the plaque-associated neuritic pathology in the hippocampus of young (4- to 6-month-old) PS1M146L/APP751SL mice model, as the initial degenerative process underlying functional disturbance prior to neuronal loss. Neuritic plaques accounted for almost all fibrillar deposits and an axonal origin of the dystrophies was demonstrated. The early induction of autophagy pathology was evidenced by increased protein levels of the autophagosome marker LC3 that was localized in the axonal dystrophies, and by electron microscopic identification of numerous autophagic vesicles filling and causing the axonal swellings. Early neuritic cytoskeletal defects determined by the presence of phosphorylated tau (AT8-positive) and actin–cofilin rods along with decreased levels of kinesin-1 and dynein motor proteins could be responsible for this extensive vesicle accumulation within dystrophic neurites. Although microsomal Aβ oligomers were identified, the presence of A11-immunopositive Aβ plaques also suggested a direct role of plaque-associated Aβ oligomers in defective axonal transport and disease progression. Most importantly, presynaptic terminals morphologically disrupted by abnormal autophagic vesicle buildup were identified ultrastructurally and further supported by synaptosome isolation. Finally, these early abnormalities in axonal and presynaptic structures might represent the morphological substrate of hippocampal dysfunction preceding synaptic and neuronal loss and could significantly contribute to AD pathology in the preclinical stages.
186 citations
Authors
Showing all 20465 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Aaron Dominguez | 147 | 1968 | 113224 |
Jose M. Ordovas | 123 | 1024 | 70978 |
Detlef Lohse | 104 | 1075 | 42787 |
Miroslav Krstic | 95 | 955 | 42886 |
María Vallet-Regí | 95 | 711 | 41641 |
John S. Sperry | 93 | 160 | 35602 |
Jose Rodriguez | 93 | 803 | 58176 |
Shun-ichi Amari | 90 | 495 | 40383 |
Michael Ortiz | 87 | 467 | 31582 |
Bruce J. Paster | 84 | 261 | 28661 |
Floyd E. Dewhirst | 81 | 229 | 42613 |
Joan Montaner | 80 | 489 | 22413 |
Francisco B. Ortega | 79 | 503 | 26069 |
Luis Paz-Ares | 77 | 592 | 31496 |