University of Seville

About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.

Resveratrol as an anti-inflammatory and anti-aging agent: mechanisms and clinical implications.

Abstract: Resveratrol is a phytoalexin polyphenolic compound found in various plants, including grapes, berries, and peanuts. Multiple lines of compelling evidence indicate its beneficial effects on neurological, hepatic, and cardiovascular systems. Also one of the most striking biological activities of resveratrol soundly investigated during the late years has been its cancer-chemopreventive potential. In fact, recently it has been demonstrated that this stilbene blocks the multistep process of carcinogenesis at various stages: tumor initiation, promotion, and progression. One of the possible mechanisms for its biological activities involves downregulation of the inflammatory response through inhibition of synthesis and release of pro-inflammatory mediators, modification of eicosanoid synthesis, inhibition of activated immune cells, or inhibiting such as inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) via its inhibitory effects on nuclear factor (kappa)B (NF-(kappa)B) or the activator protein-1 (AP-1). More recent data provide interesting insights into the effect of this compound on the lifespan of yeast and flies, implicating the potential of resveratrol as an anti-aging agent in treating age-related human diseases. It is worthy to note that the phenolic compound possesses a low bioavailability and rapid clearance from the plasma. As the positive effects of resveratrol on inflammatory response regulation may comprise relevant clinical implications, the purpose of this article is to review its strong anti-inflammatory activity and the plausible mechanisms of these effects. Also, this review is intended to provide the reader an up-date of the bioavailability and pharmacokinetics of resveratrol and its impact on lifespan.

The Correlation Coefficient: An Overview

Abstract: Correlation and regression are different, but not mutually exclusive, techniques. Roughly, regression is used for prediction (which does not extrapolate beyond the data used in the analysis) whereas correlation is used to determine the degree of association. There situations in which the x variable is not fixed or readily chosen by the experimenter, but instead is a random covariate to the y variable. This paper shows the relationships between the coefficient of determination, the multiple correlation coefficient, the covariance, the correlation coefficient and the coefficient of alienation, for the case of two related variables x and y. It discusses the uses of the correlation coefficient r, either as a way to infer correlation, or to test linearity. A number of graphical examples are provided as well as examples of actual chemical applications. The paper recommends the use of z Fisher transformation instead of r values because r is not normally distributed but z is (at least in approximation). For eithe...