Institution
University of Seville
Education•Seville, Andalucía, Spain•
About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.
Topics: Population, Model predictive control, Control theory, Nonlinear system, Context (language use)
Papers published on a yearly basis
Papers
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TL;DR: In this paper, the authors consider spiking neural P systems as binary string generators, where the set of spike trains of halting computations of a given system constitutes the language generated by that system.
Abstract: We continue the study of spiking neural P systems by considering these computing devices as binary string generators: the set of spike trains of halting computations of a given system constitutes the language generated by that system. Although the "direct" generative capacity of spiking neural P systems is rather restricted (some very simple languages cannot be generated in this framework), regular languages are inverse-morphic images of languages of finite spiking neural P systems, and recursively enumerable languages are projections of inverse-morphic images of languages generated by spiking neural P systems.
170 citations
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TL;DR: In this paper, a model of dopaminergic neurodegeneration based on the injection of the inflammatory agent lipopolysaccharide (LPS) within the substantia nigra was assayed in rats with ulcerative colitis (UC) induced by the ingestion of dextran sulphate sodium.
Abstract: Peripheral inflammation could play a role in the origin and development of certain neurodegenerative disorders. To ascertain this possibility, a model of dopaminergic neurodegeneration based on the injection of the inflammatory agent lipopolysaccharide (LPS) within the substantia nigra was assayed in rats with ulcerative colitis (UC) induced by the ingestion of dextran sulphate sodium. We found an increase in the levels of inflammatory markers from serum (tumor necrosis factor-α, IL-1β, IL-6 and the acute phase protein C-reactive protein) and substantia nigra (tumor necrosis factor-α, IL-1β, IL-6, inducible nitric oxide synthase, intercellular adhesion molecule-1, microglial and astroglial populations) of rats with UC, as well as an alteration of the blood-brain barrier permeability and the loss of dopaminergic neurons. UC reinforced the inflammatory and deleterious effects of LPS. On the contrary, clodronate encapsulated in liposomes (ClodLip), which depletes peripheral macrophages, ameliorated the effect of LPS and UC. Peripheral inflammation might represent a risk factor in the development of Parkinson's disease.
170 citations
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TL;DR: The inhibition profile of this fullerene iminosugar ball has been systematically evaluated against various glycosidases, and dramatic multivalent effects have been observed for the first time.
Abstract: The electronic and structural properties of fullerene derivatives make them very attractive candidates for the construction of nanostructures that are potentially useful for applications in materials science and biological chemistry. In particular, the C60 hexakis adducts with a Th-symmetrical octahedral addition pattern initially developed by Hirsch and co-workers are unique organic molecules with an appealing compact spherical scaffold for the construction of multifunctional nanomaterials. However, the synthesis of functionalized fullerene hexakis adducts from malonates and C60 is difficult. 4] This major problem limits the applications of such systems and has been recently solved by the development of synthetic methodologies based on the postfunctionalization of easily accessible building blocks of fullerene hexakis adducts. 6] It has been shown that fullerene hexakis adducts that bear 12 peripheral carbohydrate moieties can be prepared in excellent yields by grafting unprotected sugar derivatives onto the fullerene core. Although these fullerene sugar balls are obviously perfectly suited for applications in the field of carbohydrate–lectin interactions, the evaluation of carbohydrate-processing enzyme inhibition with such multivalent derivatives is less obvious. Indeed, among the possible strategies to attain specific potent glycosidase inhibition, the concept of multivalent design has been clearly overlooked. Most enzymes actually have a single, deep active site that is usually less accessible than the shallow binding pockets or grooves on the lectin surfaces. Consequently, a limited number of binding mechanisms, including statistical rebinding, are possible, whereas multivalent ligands may interact with multiple receptors by additional mechanistic options (e.g., the chelate effect, receptor clustering). It is likely that these factors may have hampered interest in projects directed towards the design of multivalent glycosidase inhibitors. In addition, the experimental results obtained to date were not particularly encouraging. Dito tetravalent analogues of 1-deoxynojirimycin, which is a well-known glycosidase inhibitor, generally displayed comparable if not decreased inhibition compared with their monomeric counterparts. The best result reported to date was found for a trivalent iminosugar that showed a sixfold affinity enhancement towards Jack bean a-mannosidase. Herein we report the synthesis of a fullerene hexakis adduct decorated with 12 iminosugar residues. The inhibition profile of this fullerene iminosugar ball has been systematically evaluated against various glycosidases, and dramatic multivalent effects have been observed for the first time. In order to explore the potential of multivalency on glycosidase inhibition with a globular polytopic ligand constructed around the fullerene scaffold, an N-alkyl analogue of 1-deoxynojirimycin was selected as the peripheral ligand. This class of compounds is indeed poorly selective and displays modest to good glycosidase inhibition. It was thus anticipated that these compounds could be excellent models for the examination of the influence of multivalency on inhibition selectivity over a large range of glycosidases. In addition, the alkyl chain on the endocyclic nitrogen atom of the iminosugar is an ideal spacer that may allow for easy grafting onto the central C60 core by means of a cycloaddition reaction. [16] The synthesis of the azide building block is based on the optimization of a strategy reported independently by Overkleeft et al. and Vasella and co-workers. As shown in Scheme 1, the d-hydroxy amide 2 was obtained directly from commercially available tetra-O-benzyl d-glucopyranose (1) in 78% yield by oxidative amidation with iodine in 30% aqueous ammonia (30%). The main advantage of this onepot process is that aldehyde oxidation and C N bond formation are performed in a single synthetic step. Oxidation of the hydroxy group at C5 followed by intramolecular [*] Prof. P. Compain, C. Decroocq, Dr. D. Hazelard Laboratoire de Synth se Organique et Mol cules Bioactives Universit de Strasbourg et CNRS (UMR 7509) Ecole Europ enne de Chimie, Polym res et Mat riaux 25 rue Becquerel, 67087 Strasbourg (France) Fax: (+ 33)3-6885-2754 E-mail: philippe.compain@unistra.fr
170 citations
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TL;DR: Four different antioxidant tests were used to determine the free-radical scavenging activity of 39 extra virgin olive oils and compare the total phenol content by the Folin-Ciocalteu method; the Picual variety of extra-virgin olive oil showed high antioxidant activity.
169 citations
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TL;DR: In this article, the effects of peripheral and central VIth nerve axotomy on abducens nucleus synaptic potentials of vestibular origin and the ultrastructure of intracellularly labeled ABducens motoneurons were examined in the anesthetized cat.
169 citations
Authors
Showing all 20465 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Aaron Dominguez | 147 | 1968 | 113224 |
Jose M. Ordovas | 123 | 1024 | 70978 |
Detlef Lohse | 104 | 1075 | 42787 |
Miroslav Krstic | 95 | 955 | 42886 |
María Vallet-Regí | 95 | 711 | 41641 |
John S. Sperry | 93 | 160 | 35602 |
Jose Rodriguez | 93 | 803 | 58176 |
Shun-ichi Amari | 90 | 495 | 40383 |
Michael Ortiz | 87 | 467 | 31582 |
Bruce J. Paster | 84 | 261 | 28661 |
Floyd E. Dewhirst | 81 | 229 | 42613 |
Joan Montaner | 80 | 489 | 22413 |
Francisco B. Ortega | 79 | 503 | 26069 |
Luis Paz-Ares | 77 | 592 | 31496 |