University of Seville

About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.

Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications.

Abstract: Resveratrol (3,4′,5-trihydroxystilbene) is found in various plants, including grapes, berries and peanuts. It is also present in wines, especially red wines. During the last years, it has been the focus of numerous in vitro and in vivo studies investigating its biological attributes, which include mainly antioxidant and anti-inflammatory activities, anti-platelet aggregation effect, anti-atherogenic property, oestrogen-like growth-promoting effect, growth-inhibiting activity, immunomodulation and chemoprevention. In fact, recently, it has been demonstrated that the stilbene blocks the multistep process of carcinogenesis at various stages: tumour initiation, promotion and progression. More recent results provide interesting insights into the effect of this compound on the life span of yeasts and flies, implicating the potential of resveratrol as an anti-aging agent in treating age-related human diseases. Nevertheless, depending on the concentration of the phytoalexin and the cell type, it has also been shown that resveratrol can exhibit pro-oxidant properties, leading to oxidative breakage of cellular DNA in the presence of transition metal ions such as copper. Recently, it has been proposed that such a pro-oxidant action could be a common mechanism for anticancer and chemopreventive properties of plant polyphenols. The present paper is intended to provide the reader up-to-date information on the antioxidant and pro-oxidant properties of resveratrol and its clinical implications.

The flipped voltage follower: a useful cell for low-voltage low-power circuit design

Abstract: In this paper, a basic cell for low-power and/or low-voltage operation is identified. It is evidenced how different versions of this cell, coined as "flipped voltage follower (FVF)" have been used in the past for many applications. A detailed classification of basic topologies derived from the FVF is given. In addition, a comprehensive list of recently proposed low-voltage/low-power CMOS circuits based on the FVF is given. Although the paper has a tutorial taste, some new applications of the FVF are also presented and supported by a set of simulated and experimental results. Finally, a design example showing the application of the FVF to build systems based on translinear loops is described which shows the potential of this cell for the design of high-performance low-power/low-voltage analog and mixed-signal circuits.

Human adult stem cells derived from adipose tissue protect against experimental colitis and sepsis

Abstract: Background and aims: Inflammatory bowel diseases (IBDs) are associated with uncontrolled innate and adaptive immunity against normal constituents, including commensal bacteria and microbial products. Mesenchymal stem cells (MSCs) suppress effector T cell responses and have beneficial effects in various immune disorders. This work investigates the therapeutic effects of human adipose-derived MSCs (hASCs) in various models of IBD and sepsis. Methods: Acute and chronic colitis was induced in mice with dextran sulfate sodium. Sepsis was induced by caecal ligation and puncture or by endotoxin injection. Colitic and septic mice were treated intraperitoneally with hASCs or murine ASCs, and diverse disease clinical signs and mortality were determined. The levels of various inflammatory cytokines and chemokines, T helper 1(Th1)-type response and generation of regulatory T cells (Treg) were determined in affected organs. Results: Systemic infusion of ASCs significantly ameliorated the clinical and histopathological severity of colitis, abrogating weight loss, diarrhoea and inflammation, and increasing survival. The therapeutic effect was associated with downregulation of the Th1-driven inflammatory responses. ASCs decreased a wide panel of inflammatory cytokines and chemokines and increased interleuklin 10 (IL10), acting on macrophages. hASCs also impaired Th1 cell activation in both colonic mucosa and draining lymph nodes. The induction of IL10-secreting Treg was partially involved in the therapeutic effect of hASCs. Moreover, ASCs protected from severe sepsis by reducing the infiltration of inflammatory cells in various target organs and by downregulating the production of various inflammatory mediators. Conclusions: hASCs emerge as key regulators of immune/inflammatory responses in vivo and as attractive candidates for cell-based treatments for IBD and sepsis.

Recent Advances in the Design, Modeling, and Control of Multiphase Machines—Part II

Abstract: The main objective of this two-part state-of-the-art paper called “Recent Advances in the Design, Modeling, and Control of Multiphase Machines” is to present latest contributions in the multiphase machines' field. The first part of this paper focuses on the recent progress in the design, modeling, and control, whereas the drive is in healthy operation. This second part presents relevant contributions in two not analyzed fields. The first is in relation with the use of the additional degrees of freedom of multiphase machines and the exploitation of their fault-tolerant capabilities without adding extra hardware. The second one analyzes multiphase generation, particularly in grid-connected wind energy conversion systems and stand-alone applications. Recent progresses are shown and open challenges and future research directions are discussed.