Institution
University of Seville
Education•Seville, Andalucía, Spain•
About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.
Topics: Population, Context (language use), Model predictive control, Nonlinear system, Control theory
Papers published on a yearly basis
Papers
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TL;DR: The present report discusses that the high levels of H( 2)O(2) commonly observed in cancer cells may be essential for cancer development; these high levels, however, seem almost incompatible with cell survival and may make cancer cells more susceptible to H(2)-induced cell death than normal cells.
606 citations
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TL;DR: The presence of immune system-synthesized melatonin, its direct immunomodulatory effects on cytokine production, and its masking effects on exogenous melatonin action are summarized.
Abstract: This review summarizes the numerous observations published in recent years which have shown that one of the most significant of melatonin’s pleiotropic effects is the regulation of the immune system. The overview summarizes the immune effects of pinealectomy and the association between rhythmic melatonin production and adjustments in the immune system as markers of melatonin’s immunomodulatory actions. The effects of both in vivo and in vitro melatonin administration on non-specific, humoral, and cellular immune responses as well as on cellular proliferation and immune mediator production are presented. One of the main features that distinguishes melatonin from the classical hormones is its synthesis by a number of nonendocrine extrapineal organs, including the immune system. Herein, we summarize the presence of immune system-synthesized melatonin, its direct immunomodulatory effects on cytokine production, and its masking effects on exogenous melatonin action. The mechanisms of action of melatonin in the immune system are also discussed, focusing attention on the presence of membrane and nuclear receptors and the characterization of several physiological roles mediated by some receptor analogs in immune cells. The review focuses on melatonin’s actions in several immune pathologies including infection, inflammation, and autoimmunity together with the relation between melatonin, immunity, and cancer.
605 citations
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National Autonomous University of Mexico1, National University of Comahue2, University of Jaén3, University of Seville4, National University of Cordoba5, Sao Paulo State University6, Spanish National Research Council7, University of Oviedo8, University of Granada9, University of Chile10, University of Vigo11, Central University of Venezuela12
TL;DR: A novel model proposes a novel approach that relates the diversity of both species and interactions along a gradient of environmental deterioration and explores how the rate of loss of ecological functions, and consequently of ecosystem services, can be accelerated or restrained depending on how the rates of species loss covaries with the rateof interactions loss.
Abstract: Summary 1. The effects of the present biodiversity crisis have been largely focused on the loss of species. However, a missed component of biodiversity loss that often accompanies or even precedes species disappearance is the extinction of ecological interactions. 2. Here, we propose a novel model that (i) relates the diversity of both species and interactions along a gradient of environmental deterioration and (ii) explores how the rate of loss of ecological functions, and consequently of ecosystem services, can be accelerated or restrained depending on how the rate of species loss covaries with the rate of interactions loss. 3. We find that the loss of species and interactions are decoupled, such that ecological interactions are often lost at a higher rate. This implies that the loss of ecological interactions may occur well before species disappearance, affecting species functionality and ecosystems services at a faster rate than species extinctions. We provide a number of empirical case studies illustrating these points. 4. Our approach emphasizes the importance of focusing on species interactions as the major biodiversity component from which the ‘health’ of ecosystems depends.
603 citations
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17 Jun 2005TL;DR: A proposal to model and reason on an SPL using constraint programming is introduced, taking into account functional and extra–functional features, improve current proposals and present a running, yet feasible implementation.
Abstract: Software Product Line (SPL) Engineering has proved to be an effective method for software production. However, in the SPL community it is well recognized that variability in SPLs is increasing by the thousands. Hence, an automatic support is needed to deal with variability in SPL. Most of the current proposals for automatic reasoning on SPL are not devised to cope with extra–functional features. In this paper we introduce a proposal to model and reason on an SPL using constraint programming. We take into account functional and extra–functional features, improve current proposals and present a running, yet feasible implementation.
603 citations
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TL;DR: A detailed step-by-step guide to analytical method validation, considering the most relevant procedures for checking the quality parameters of analytical methods and the estimation of measurement uncertainty and accuracy profiles is given.
Abstract: The objective of analytical method validation is to ensure that every future measurement in routine analysis will be close enough to the unknown true value for the content of the analyte in the sample. Classical approaches to validation only check performance against reference values, but this does not reflect the needs of consumers. A holistic approach to validation also takes into account the expected proportion of acceptable results lying inside predefined acceptability intervals. In this article, we give a detailed step-by-step guide to analytical method validation, considering the most relevant procedures for checking the quality parameters of analytical methods. Using a holistic approach, we also explain the estimation of measurement uncertainty and accuracy profiles, which we discuss in terms of accreditation requirements and predefined acceptability limits.
598 citations
Authors
Showing all 20465 results
Name | H-index | Papers | Citations |
---|---|---|---|
Russel J. Reiter | 169 | 1646 | 121010 |
Aaron Dominguez | 147 | 1968 | 113224 |
Jose M. Ordovas | 123 | 1024 | 70978 |
Detlef Lohse | 104 | 1075 | 42787 |
Miroslav Krstic | 95 | 955 | 42886 |
María Vallet-Regí | 95 | 711 | 41641 |
John S. Sperry | 93 | 160 | 35602 |
Jose Rodriguez | 93 | 803 | 58176 |
Shun-ichi Amari | 90 | 495 | 40383 |
Michael Ortiz | 87 | 467 | 31582 |
Bruce J. Paster | 84 | 261 | 28661 |
Floyd E. Dewhirst | 81 | 229 | 42613 |
Joan Montaner | 80 | 489 | 22413 |
Francisco B. Ortega | 79 | 503 | 26069 |
Luis Paz-Ares | 77 | 592 | 31496 |