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Institution

University of Seville

EducationSeville, Andalucía, Spain
About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.


Papers
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Journal ArticleDOI
TL;DR: A predictive-torque-control method is introduced as an alternative to the DTC technique for the high-performance variable-speed operation of multiphase drives.
Abstract: Multiphase electric drives have been recently proposed for applications where the highest overall system reliability and a reduction in the total power per phase are required. Strategies derived from the conventional field-oriented control have been traditionally used in high-performance speed-control applications of multiphase drives. The well-known direct torque control (DTC) technique has been also applied in the multiphase case, but the achieved performance with a hysteresis-control-based approach is far from that obtainable with the three-phase drive, although the control structure is actually more complex. In this paper, a predictive-torque-control method is introduced as an alternative to the DTC technique for the high-performance variable-speed operation of multiphase drives. Simulation and experimental results are provided to illustrate the properties of the developed method.

156 citations

Journal ArticleDOI
TL;DR: A case study on LCA of mussel cultivation in rafts shows that direct link between operational efficiency and environmental impacts can help to convince the managers and operators of the cultivation sites of the double dividend of reducing inputs consumption and achieve operational efficiency: lower costs and lower environmental impacts.

156 citations

Journal ArticleDOI
TL;DR: A case by case toxicological evaluation is required taking into account that different clays have their own toxicological profiles, their modification can change this profile, and the potential increase of the human/environmental exposure to clay minerals due to their novel applications.

156 citations

Journal ArticleDOI
TL;DR: A better knowledge of the molecular mechanisms that mediate leptin action may be helpful to understand the underlying processes which link obesity to breast cancer in post-menopausal women, as well as the possible role of leptin in the response to immunotherapy in obese patients.
Abstract: Obesity-related breast cancer is an important threat that affects especially post-menopausal women. The link between obesity and breast cancer seems to be relying on the microenvironment generated at adipose tissue level, which includes inflammatory cytokines. In addition, its association with systemic endocrine changes, including hyperinsulinemia, increased estrogens levels, and hyperleptinemia may be key factors for tumor development. These factors may promote tumor initiation, tumor primary growth, tissue invasion, and metastatic progression. Although the relationship between obesity and breast cancer is already established, the different pathophysiological mechanisms involved are not clear. Obesity-related insulin resistance is a well-known risk factor for breast cancer development in post-menopausal women. However, the role of inflammation and other adipokines, especially leptin, is less studied. Leptin, like insulin, appears to be a growth factor for breast cancer cells. There exists a link between leptin and metabolism of estrogens and between leptin and other factors in a more complex network. As a result, obesity-associated hyperleptinemia has been suggested as an important mediator in the pathophysiology of breast cancer. On the other hand, recent data on the paradoxical effect of obesity on cancer immunotherapy efficacy has brought some controversy, since the proinflammatory effect of leptin may help the effect of immune checkpoint inhibitors. Therefore, a better knowledge of the molecular mechanisms that mediate leptin action may be helpful to understand the underlying processes which link obesity to breast cancer in post-menopausal women, as well as the possible role of leptin in the response to immunotherapy in obese patients.

155 citations

Journal ArticleDOI
TL;DR: The topical antiinflammatory activity of the hexane extract and of stigmasterol was evaluated by auricular oedema, induced by 12‐0‐tetradecanoylphorbol acetate (TPA), in the mouse, using single and multiple applications of the phlogistic agent.
Abstract: Eryngium foetidum L. (Apiaceae) is a Caribbean endemic plant, used in folk medicine for the treatment of several antiinflammatory disorders. A preliminary phytochemical study showed that the hexane extract is rich in terpenic compounds. Chromatographic fractionation of this extract yielded: alpha-cholesterol, brassicasterol, campesterol, stigmasterol (as the main component, 95%) clerosterol, beta-sitosterol, delta 5-avenasterol, delta (5)24-stigmastadienol and delta 7-avenasterol. The topical antiinflammatory activity of the hexane extract and of stigmasterol was evaluated by auricular oedema, induced by 12-0-tetradecanoylphorbol acetate (TPA), in the mouse, using single and multiple applications of the phlogistic agent. Both reduced the oedema in a similar proportion in the two model assays (acute and chronic). Meloperoxidase activity was strongly reduced by both the extract and the compound, in the acute but not the chronic model. These results indicate that the leaves of Eryngium foetidum L may be effective against topical inflammation processes. Stigmasterol also exerts a significant topical antiinflammatory activity although it cannot be considered to be a major antiinflammatory agent, therefore other bioactive components are probably involved in the activity of the hexane extract.

155 citations


Authors

Showing all 20465 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Aaron Dominguez1471968113224
Jose M. Ordovas123102470978
Detlef Lohse104107542787
Miroslav Krstic9595542886
María Vallet-Regí9571141641
John S. Sperry9316035602
Jose Rodriguez9380358176
Shun-ichi Amari9049540383
Michael Ortiz8746731582
Bruce J. Paster8426128661
Floyd E. Dewhirst8122942613
Joan Montaner8048922413
Francisco B. Ortega7950326069
Luis Paz-Ares7759231496
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023143
2022567
20213,357
20203,480
20193,032
20182,766