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Institution

University of Seville

EducationSeville, Andalucía, Spain
About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.


Papers
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Journal ArticleDOI
TL;DR: Recent genome-wide methods for determining mRNA half-lives in eukaryotes are discussed and pre- and posttranscriptional regulons that coordinate the fate of functionally related mRNAs by using protein- or RNA-based trans factors are reviewed.

146 citations

Journal ArticleDOI
TL;DR: This paper focuses on a methodological framework for the development of an automated data imputation model based on artificial neural networks, and suggests this approach improves the quality of a database with missing values.

146 citations

Journal ArticleDOI
TL;DR: In this paper, self-similar solutions for the motion of an aqueous solution in a constant temperature gradient placed on top of two coplanar electrodes subjected to an a.c. signal, generating a rotating field are presented.
Abstract: Electrothermal motion in an aqueous solution arises from the action of an electric field on inhomogeneities in the liquid induced by temperature gradients. The temperature field can be produced by the applied electric field through Joule heating, or caused by external sources, such as strong illumination. Electrothermal flows in microsystems are usually observed at applied signal frequencies around 1 MHz and voltages around 10 V. In this work, we present self-similar solutions for the motion of an aqueous solution in a constant temperature gradient placed on top of: (a) two coplanar electrodes subjected to an a.c. potential difference, and (b) four coplanar electrodes subjected to a four-phase a.c. signal, generating a rotating field. The first case produces two-dimensional rolls whereas the second case produces a liquid whirl. Finally, we present experimental results of electrothermal liquid flows generated by alternating and rotating electric fields under strong illumination, and these experiments are compared to the analytical solutions. The induced rotating flow could be used in the mixing of analytes and of liquids in microsystems.

145 citations

Journal ArticleDOI
TL;DR: Investigation of the effects of VIP and PACAP on the production of interleukin‐6 by endotoxin‐activated murine macrophages supports the idea that in the absence of stimulation or in the presence of low doses of LPS, VIP andPACAP could play a role in immune system homeostasis.
Abstract: Vasoactive intestinal peptide (VIP) is a neuropeptide synthesized by immune cells that can modulate several immune aspects, including the function of cells involved in the inflammatory response, such as macrophages and monocytes. Production and release of cytokines by activated mononuclear phagocytes is an important event in the pathogenesis of ischemia-reperfusion injury. VIP has been shown to attenuate the deleterious consequences of this pathologic phenomenon. We have investigated the effects of VIP and PACAP38 on the production of interleukin-6 (IL-6), a proinflammatory cytokine, by endotoxin-activated murine macrophages. Both neuropeptides exhibit a dual effect on the IL-6 production by peritoneal macrophages. Whereas VIP and PACAP inhibit with similar dose-response curves the release of IL-6 from macrophages stimulated with a LPS dose range from 100 pg/mL to 10 microg/mL, both neuropeptides enhance IL-6 secretion in unstimulated macrophages and in macrophages stimulated with very low LPS concentrations (1-10 pg/mL). The inhibition on LPS-induced IL-6 production is specific, presumably mediated through a subtype of the PACAP-R. VIP and PACAP regulate the production of IL-6 at a transcriptional level. These results were correlated with an inhibition on both IL-6 expression and release in endotoxemic mice in vivo. These findings support the idea that in the absence of stimulation or in the presence of low doses of LPS, VIP and PACAP could play a role in immune system homeostasis. However, under toxicity conditions associated with high LPS doses, VIP and PACAP could act as protective mediators that regulate the excessive release of IL-6 in order to reduce inflammation or shock.

145 citations


Authors

Showing all 20465 results

NameH-indexPapersCitations
Russel J. Reiter1691646121010
Aaron Dominguez1471968113224
Jose M. Ordovas123102470978
Detlef Lohse104107542787
Miroslav Krstic9595542886
María Vallet-Regí9571141641
John S. Sperry9316035602
Jose Rodriguez9380358176
Shun-ichi Amari9049540383
Michael Ortiz8746731582
Bruce J. Paster8426128661
Floyd E. Dewhirst8122942613
Joan Montaner8048922413
Francisco B. Ortega7950326069
Luis Paz-Ares7759231496
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
2023143
2022567
20213,357
20203,480
20193,032
20182,766