University of Seville

About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Context (language use). The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.

A Multilevel State Estimation Paradigm for Smart Grids

Abstract: The main objective of this paper is to describe a multilevel framework that facilitates seamless integration of existing state estimators (SEs) that are designed to function at different levels of modeling hierarchy in order to accomplish very large-scale monitoring of interconnected power systems. This has been a major challenge for decades as power systems grew pretty much independently in different areas, which had to operate in an interconnected and synchronized fashion. The paper initially provides a brief historical perspective which also explains the existing state estimation paradigm. This is followed by a review of the recent technological and regulatory drivers that are responsible for the new developments in the energy management functions. The paper then shows that a common theoretical framework can be used to implement a hierarchical scheme by which even very large-scale power systems can be efficiently and accurately monitored. This is illustrated for substation level, transmission system level as well as for a level between different transmission system operators in a given power system. Finally, the paper describes the use and benefits of phasor measurements when incorporated at these different levels of the proposed infrastructure. Numerical examples are included to illustrate performance of the proposed multilevel schemes.

Roles of β-Lactamases and Porins in Activities of Carbapenems and Cephalosporins against Klebsiella pneumoniae

Abstract: Two clinical isolates of extended-spectrum beta-lactamase (ESBL)-producing Klebsiella pneumoniae were noted to be less susceptible than expected to imipenem. Both were missing outer membrane proteins that serve as channels for antibiotic entry. The role of beta-lactamase in resistance was investigated by eliminating the original ESBL and introducing plasmids encoding various ESBLs and AmpC beta-lactamase types, by studying the effect of an increased inoculum, and by evaluating interactions with beta-lactamase inhibitors. The contribution of porin deficiency was investigated by restoring a functional ompK36 gene on a plasmid. Plasmids encoding AmpC-type beta-lactamases provided resistance to imipenem (up to 64 microg/ml) and meropenem (up to 16 microg/ml) in strains deficient in porins. Carbapenem resistance showed little inoculum effect, was not affected by clavulanate but was blocked by BRL 42715, and was diminished if OmpK36 porin was restored. Plasmids encoding TEM- and SHV-type ESBLs conferred resistance to cefepime and cefpirome, as well as to earlier oxyimino-beta-lactams. This resistance was magnified with an increased inoculum, was blocked by clavulanate, and was also lowered by OmpK36 porin restoration. In addition, SHV-2 beta-lactamase had a small effect on carbapenem resistance (imipenem MIC, 4 microg/ml, increasing to 16 microg/ml with a higher inoculum) when porins were absent. In K. pneumoniae porin loss can thus augment resistance provided either by TEM- or SHV-type ESBLs or by plasmid-mediated AmpC enzymes to include the latest oxyimino-beta-lactams and carbapenems.

Short and long fatigue crack growth: A unified model

Abstract: In this model the growth of a crack is analysed in terms of the successive blocking of the plastic zone by slip barriers (e.g. grain boundaries) and the subsequent initiation of the slip in the next grain. The discontinuous character of the slip process (slip jumps) plays a fundamental role in the model. The factor governing the transfer of slip across a grain boundary is considered to be the stress concentration ahead of the plastic zone which, for a constant applied stress τ, is found to be dependent only on a parameter n = a/c defining the position of the crack tip relative to the grain boundary. The discrete behaviour of the slip has a strong influence in the short-crack period and hence cannot be neglected in the analysis of the crack growth rate. This period is characterized by large variations in the parameter n. In the long-crack period the slip jumps do not influence the overall description of the growth and the parameter n is almost constant. By making the crack extension per cycle prop...