University of Seville

About: University of Seville is a education organization based out in Seville, Andalucía, Spain. It is known for research contribution in the topics: Population & Model predictive control. The organization has 20098 authors who have published 47317 publications receiving 947007 citations. The organization is also known as: Universidad de Sevilla.

The molecular underpinning of lobular histological growth pattern: a genome-wide transcriptomic analysis of invasive lobular carcinomas and grade- and molecular subtype-matched invasive ductal carcinomas of no special type.

Abstract: Invasive lobular carcinoma (ILC) is the most frequent special type of breast cancer. The majority of these tumours are of low histological grade, express hormone receptors, and lack HER2 expression. The pleomorphic variant of ILCs (PLCs) is characterized by atypical cells with pleomorphic nuclei and is reported to have an aggressive clinical behaviour. Expression profiling studies have demonstrated that classic ILCs preferentially display a luminal phenotype, whereas PLCs may be of luminal, HER2 or molecular apocrine subtypes. The aims of this study were two-fold: to determine the transcriptomic characteristics of lobular carcinomas and to define the genome-wide transcriptomic differences between classic ILCs and PLCs. To define the transcriptomic characteristics of ILCs, minimizing the impact of histological grade and molecular subtype on the analysis, we subjected a series of grade- and molecular subtype-matched ILCs and invasive ductal carcinomas (IDCs) to genome-wide gene expression profiling using oligonucleotide microarrays. Hierarchical clustering analysis demonstrated that ILCs formed a separate cluster and a supervised analysis revealed that 5.8% of the transcriptionally regulated genes were significantly differentially expressed in ILCs compared to grade- and molecular subtype-matched IDCs. ILCs displayed down-regulation of E-cadherin and of genes related to actin cytoskeleton remodelling, protein ubiquitin, DNA repair, cell adhesion, TGF-beta signalling; and up-regulation of transcription factors/immediate early genes, lipid/prostaglandin biosynthesis genes, and cell migration-associated genes. Supervised analysis of classic ILCs and PLCs demonstrated that less than 0.1% of genes were significantly differentially expressed between these tumour subtypes. Our results demonstrate that ILCs differ from grade- and molecular subtype-matched IDCs in the expression of genes related to cell adhesion, cell-to-cell signalling, and actin cytoskeleton signalling. However, classic ILCs and PLCs are remarkably similar at the molecular level and should be considered as part of a spectrum of lesions.

Cascaded H-bridge multilevel converter multistring topology for large scale photovoltaic systems

Abstract: Large scale grid connected photovoltaic (PV) energy conversion systems have reached the megawatt level. This imposes new challenges on existing grid interface converter topologies and opens new opportunities to be explored. In this paper a new medium voltage multilevel-multistring configuration is introduced based on a three-phase cascaded H-bridge (CHB) converter and multiple string dc-dc converters. The proposed configuration enables a large increase of the total capacity of the PV system, while improving power quality and efficiency. The converter structure is very flexible and modular since it decouples the grid converter from the PV string converter, which allows to accomplish independent control goals. The main challenge of the proposed configuration is to handle the inherent power imbalances that occur not only between the different cells of one phase of the converter but also between the three phases. The control strategy to deal with these imbalances is also introduced in this paper. Simulation results of a 7-level CHB for a multistring PV system are presented to validate the proposed topology and control method.

Multiphase machines and drives - Revisited

Abstract: Although the concept of a multiphase drive system dates back to the middle of the 20th century, the initial pace of development was rather slow, as witnessed by the first two surveys of the area published in the beginning of this century. However, considerably new developments have resulted in the last decade of the 20th century and the beginning of this century, leading to an authoritative survey of the asymmetrical six-phase drive control and subsequently of the review of the complete area. This also initiated the organization and subsequent publication of the first IEEE Transactions on Industrial Electronics "Special Section on Multiphase Machines and Drives" in May 2008, which commenced with another survey paper, and that contained 12 original research papers. Since the publication of this Special Section in May 2008, the level of interest and pace of developments in the area have further accelerated and substantial new knowledge has been generatedwith an ever-increasing number of published research papers and reported new industrial applications. Such a trend has been emphasized in a recent paper. It therefore seemed appropriate to revisit the area and organize this Special Section as a sequel to the first one. The call for the Special Section papers resulted in 51 submissions, almost twice as many as the total back in 2008, thus confirming a substantial growth of the area. Indeed, the amount of new knowledge acquired since the publication of the first Special Section in 2008 has meant that it was not possible to provide a complete and thorough survey of the field in a single review paper.

Catalytic enantioselective hydrophosphonylation of aldehydes and imines

Abstract: In this review, recent advances in catalytic asymmetric hydrophosphonylation of aldehydes and imines are discussed. We also summarize several proposed mechanisms for the different possibilities of asymmetric induction and the application of this catalytic methodology to the enantioselective synthesis of α-amino and α-hydroxy phosphonates. A variety of metal-based chiral catalysts as well as several organic catalysts have been exploited as suitable systems for the preparation of enantiomerically pure phosphonates. The recent evolution and future trends of those and other catalytic systems are described.

Microwave filters with improved stopband based on sub-wavelength resonators

Abstract: The main aim of this paper is to demonstrate the potentiality of sub-wavelength resonators, namely, split-ring resonators, complementary split-ring resonators, and related structures to the suppression of undesired spurious bands in microwave filters, a key aspect to improve their rejection bandwidths. The main relevant characteristics of the cited resonators are their dimensions (which can be much smaller than signal wavelength at resonance) and their high-Q factor. This allows us to design stopband structures with significant rejection levels, few stages, and small dimensions, which can be integrated within the filter active region. By this means, no extra area is added to the device, while the passband of interest is virtually unaltered. A wide variety of bandpass filters, implemented in both coplanar-waveguide and microstrip technologies, have been designed and fabricated by the authors. The characterization of these devices points out the efficiency of the proposed approach to improve filter responses with harmonic rejection levels near 40 dB in some cases. It is also important to highlight that the conventional design methodology for the filters holds. For certain configurations, the presence of the resonators slightly lowers the phase velocity at the frequencies of interest with the added advantage of some level of reduction in device dimensions.