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Institution

University of Siena

EducationSiena, Italy
About: University of Siena is a education organization based out in Siena, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 12179 authors who have published 33334 publications receiving 1008287 citations. The organization is also known as: Università degli studi di Siena & Universita degli studi di Siena.


Papers
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Journal ArticleDOI
TL;DR: Sperm bacterial contamination is quite frequent and could contribute to the deterioration of the sperm quality of infertile men.
Abstract: To verify the prevalence of semen bacterial contamination and whether the contamination could decrease sperm quality. Spermiogram, semen culture, and sperm transmission electron microscopy (TEM) analysis were performed. TEM data were elaborated using a mathematical formula that calculates a fertility index (FI)—able to define patients as fertile or infertile—and the percentage of sperm apoptosis, immaturity and necrosis. We aligned the amino acid sequence of beta-tubulin with protein of the most frequent species isolated from semen. Patients were divided according to the contaminating species; in each group, we observed fertile individuals, in whom the semen quality was similar to that of controls and infertile men whose sperm quality was significantly decreased, in terms of motility, FI, apoptosis and necrosis. Partial homology between β-tubulin and bacterial proteins was observed. Sperm bacterial contamination is quite frequent and could contribute to the deterioration of the sperm quality of infertile men.

177 citations

Journal ArticleDOI
TL;DR: The complete 15,455-nt mitochondrial DNA sequence of the springtail Tetrodontophora bielanensis (Arthropoda, Hexapoda, Collembola), which shows the well-known A+T bias typical of insect mtDNA, and two tRNA translocations were found which were unprecedented among Arthropoda.
Abstract: We present the complete 15,455-nt mitochondrial DNA sequence of the springtail Tetrodontophora bielanensis (Arthropoda, Hexapoda, Collembola). The gene content is typical of most metazoans, with 13 protein-coding genes (PCGs), 2 genes encoding for ribosomal RNA subunits, and 22 tRNA genes. The nucleotide sequence shows the well-known A+T bias typical of insect mtDNA; its A+T content is lower (72.7%) than that observed in other insect species, but still higher than that in other arthropodan taxa. The bias appears to be uniform across the whole molecule, unlike other insect taxa, which show increased A+T content in the so-called A+T-rich region. However, the bias is slightly higher in the third codon positions of the PCGs (81.4%). Anomalous initiation codons have been observed in the nad2 and the cox1 genes. In the latter, the ATTTAA hexanucleotide is suggested to be involved in the initiation signaling. All tRNAs could be folded into the typical cloverleaf secondary structure, but the tRNA for cysteine appears to be missing the DHU arm. Long tandemly repeated regions (193 nt) were found in the A+T-rich region, which in turn was shown to have the possibility of forming a complex array of secondary structures. One of these structures encompassed the junction between the repeats. The A+T-rich region was also interesting in that it showed heteroplasmy in the number of repeats. Three haplotypes were found, possessing 2, 3, and 4 identical repeats, respectively. The order of protein coding and rRNA genes in the molecule was determined and was identical to that of all insects studied so far. However, two tRNA translocations were found which were unprecedented among Arthropoda. These involved the trnQ, which was found between the rrnS and the A+T-rich region, and the trnS(ucn), which was located between trnM and trnI. A preliminary phylogenetic analysis based on the amino acid sequence of the PCGs failed to find support for the monophyly of Hexapoda.

177 citations

Journal ArticleDOI
TL;DR: Three experiments of elicited spoken production making use of specific characteristics of Italian and French are presented and observations are shown to be naturally interpretable through the tools of formal syntax, as elaborated within the Principles and Parameters/Minimalist tradition.

177 citations

Journal ArticleDOI
TL;DR: The results suggest that the intensified schedule of tremelimumab investigated seems to have clinical and immunological activity in patients with advanced malignant mesothelioma, and a good safety profile.

177 citations


Authors

Showing all 12352 results

NameH-indexPapersCitations
Johan Auwerx15865395779
I. V. Gorelov1391916103133
Roberto Tenchini133139094541
Francesco Fabozzi133156193364
M. Davier1321449107642
Roberto Dell'Orso132141292792
Rino Rappuoli13281664660
Teimuraz Lomtadze12989380314
Manas Maity129130987465
Dezso Horvath128128388111
Paolo Azzurri126105881651
Vincenzo Di Marzo12665960240
Igor Katkov12597271845
Ying Lu12370862645
Thomas Schwarz12370154560
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022221
20211,870
20201,979
20191,639
20181,523