Institution
University of Siena
Education•Siena, Italy•
About: University of Siena is a education organization based out in Siena, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 12179 authors who have published 33334 publications receiving 1008287 citations. The organization is also known as: Università degli studi di Siena & Universita degli studi di Siena.
Topics: Population, Cancer, Large Hadron Collider, Sperm, Oxidative stress
Papers published on a yearly basis
Papers
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TL;DR: In this article, the authors compare conventional and organic poultry production in terms of emergy analysis and show that the organic poultry system is compatible with sustainable agriculture, avoiding the use of chemical compounds, limiting the intensity of production and providing controls along the entire chain of production.
176 citations
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University of Barcelona1, Medical University of Vienna2, Alameda Health System3, University of Colorado Boulder4, University of Palermo5, Federal University of Tocantins6, Northumberland, Tyne and Wear NHS Foundation Trust7, Aristotle University of Thessaloniki8, University of Montpellier9, University of Hamburg10, Li Ka Shing Faculty of Medicine, University of Hong Kong11, University of Siena12, Ludwig Maximilian University of Munich13, Paracelsus Private Medical University of Salzburg14, University of British Columbia15
TL;DR: Recommendations on the assessment of agitation emphasise the importance of identifying any possible medical cause and the “ideal” medication should calm without over-sedate.
Abstract: Background Psychomotor agitation is associated with different psychiatric conditions and represents an important issue in psychiatry. Current recommendations on agitation in psychiatry are not univocal. Actually, an improper assessment and management may result in unnecessary coercive or sedative treatments. A thorough and balanced review plus an expert consensus can guide assessment and treatment decisions. Methods An expert task force iteratively developed consensus using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new, re-worded or re-rated items. Results Out of 2175 papers assessing psychomotor agitation, 124 were included in the review. Each component was assigned a level of evidence. Integrating the evidence and the experience of the task force members, a consensus was reached on 22 statements on this topic. Conclusions Recommendations on the assessment of agitation emphasise the importance of identifying any possible...
176 citations
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TL;DR: The endogenous RT can be regarded as an epigenetic regulator of cell differentiation and proliferation and may represent a novel target in cancer therapy.
Abstract: Undifferentiated cells and embryos express high levels of endogenous non-telomerase reverse transcriptase (RT) of retroposon/retroviral origin. We previously found that RT inhibitors modulate cell growth and differentiation in several cell lines. We have now sought to establish whether high levels of RT activity are directly linked to cell transformation. To address this possibility, we have employed two different approaches to inhibit RT activity in melanoma and prostate carcinoma cell lines: pharmacological inhibition by two characterized RT inhibitors, nevirapine and efavirenz, and downregulation of expression of RT-encoding LINE-1 elements by RNA interference (RNAi). Both treatments reduced proliferation, induced morphological differentiation and reprogrammed gene expression. These features are reversible upon discontinuation of the anti-RT treatment, suggesting that RT contributes to an epigenetic level of control. Most importantly, inhibition of RT activity in vivo antagonized tumor growth in animal experiments. Moreover, pretreatment with RT inhibitors attenuated the tumorigenic phenotype of prostate carcinoma cells inoculated in nude mice. Based on these data, the endogenous RT can be regarded as an epigenetic regulator of cell differentiation and proliferation and may represent a novel target in cancer therapy.
175 citations
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TL;DR: In this paper, the Fermilab staff and technical staff of the participating institutions for their vital contributions and acknowledgment support from the DOE and NSF (USA), ARC and ARC======(Australia), CNPq, FAPERJ, FAPEESP, and FUNDUNESP======
Abstract: We thank the Fermilab staff and technical staffs of the
participating institutions for their vital contributions and
acknowledge support from the DOE and NSF (USA), ARC
(Australia), CNPq, FAPERJ, FAPESP, and FUNDUNESP
(Brazil), NSERC (Canada), NSC, CAS, and CNSF
(China), Colciencias (Colombia), MSMT and GACR
(Czech Republic), the Academy of Finland, CEA, and
CNRS/IN2P3 (France), BMBF and DFG (Germany),
DAE and DST (India), SFI (Ireland), INFN (Italy),
MEXT (Japan), the Korean World Class University
Program and NRF (Korea), CONACyT (Mexico), FOM
(Netherlands), MON, NRC KI, and RFBR (Russia), the
Slovak R&D Agency, the Ministerio de Ciencia e
Innovacio´n, and Programa Consolider-Ingenio 2010
(Spain), The Swedish Research Council (Sweden), SNSF
(Switzerland), STFC and the Royal Society (United
Kingdom), and the A. P. Sloan Foundation (USA).
175 citations
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TL;DR: The results demonstrate a close cooperation of the enzymes based on co-localization and the mutual generation of cofactors for each other in rat liver microsomal vesicles.
175 citations
Authors
Showing all 12352 results
Name | H-index | Papers | Citations |
---|---|---|---|
Johan Auwerx | 158 | 653 | 95779 |
I. V. Gorelov | 139 | 1916 | 103133 |
Roberto Tenchini | 133 | 1390 | 94541 |
Francesco Fabozzi | 133 | 1561 | 93364 |
M. Davier | 132 | 1449 | 107642 |
Roberto Dell'Orso | 132 | 1412 | 92792 |
Rino Rappuoli | 132 | 816 | 64660 |
Teimuraz Lomtadze | 129 | 893 | 80314 |
Manas Maity | 129 | 1309 | 87465 |
Dezso Horvath | 128 | 1283 | 88111 |
Paolo Azzurri | 126 | 1058 | 81651 |
Vincenzo Di Marzo | 126 | 659 | 60240 |
Igor Katkov | 125 | 972 | 71845 |
Ying Lu | 123 | 708 | 62645 |
Thomas Schwarz | 123 | 701 | 54560 |