scispace - formally typeset
Search or ask a question
Institution

University of Siena

EducationSiena, Italy
About: University of Siena is a education organization based out in Siena, Italy. It is known for research contribution in the topics: Population & Cancer. The organization has 12179 authors who have published 33334 publications receiving 1008287 citations. The organization is also known as: Università degli studi di Siena & Universita degli studi di Siena.


Papers
More filters
Journal ArticleDOI
TL;DR: The results of this study indicate that there is a direct relation between flap thickness and recession reduction (P <0.0001), and flap thickness >0.8 mm was associated with 100% of root coverage.
Abstract: This clinical study was designed to determine whether the thickness of the flap can influence root coverage when gingival recessions associated with traumatic toothbrushing are treated using a coronally advanced flap (CAF). Nineteen patients, aged from 25 to 57 years, with high levels of oral hygiene (full-mouth plaque scores or =2 mm were treated. After local anesthesia and before flap elevation, the exposed root surface was planed with a sharp curet. A trapezoidal full- and partial-thickness flap was then elevated, displaced coronally, and sutured to cover the treated root surface. Before suturing, flap thickness was measured in the alveolar mucosa with a gauge. After surgery, all patients were recalled for control and professional prophylaxis once a week during the first month and monthly up to the third month. The mean initial recession depth was 3.0+/-0.9 mm. Mean flap thickness (FT) was 0.7+/-0.2 mm. Three months later, mean recession depth was 0.6+/-0.6 (P 0.8 mm was associated with 100% of root coverage. The results of this study indicate that there is a direct relation between flap thickness and recession reduction (P <0.0001).

323 citations

Journal ArticleDOI
TL;DR: Long-term followup of patients from the ELNT confirms that, in lupus nephritis, a remission-inducing regimen of low-dose IV CYC followed by AZA achieves clinical results comparable with those obtained with a high-dose regimen.
Abstract: OBJECTIVE: In the Euro-Lupus Nephritis Trial (ELNT), 90 patients with lupus nephritis were randomly assigned to a high-dose intravenous cyclophosphamide (IV CYC) regimen (6 monthly pulses and 2 quarterly pulses with escalating doses) or a low-dose IV CYC regimen (6 pulses of 500 mg given at intervals of 2 weeks), each of which was followed by azathioprine (AZA). After a median followup of 41 months, a difference in efficacy between the 2 regimens was not observed. The present analysis was undertaken to extend the followup and to identify prognostic factors. METHODS: Renal function was prospectively assessed quarterly in all 90 patients except 5 who were lost to followup. Survival curves were derived using the Kaplan-Meier method. RESULTS: After a median followup of 73 months, there was no significant difference in the cumulative probability of end-stage renal disease or doubling of the serum creatinine level in patients who received the low-dose IV CYC regimen versus those who received the high-dose regimen. At long-term followup, 18 patients (8 receiving low-dose and 10 receiving high-dose treatment) had developed permanent renal impairment and were classified as having poor long-term renal outcome. We demonstrated by multivariate analysis that early response to therapy at 6 months (defined as a decrease in serum creatinine level and proteinuria <1 g/24 hours) was the best predictor of good long-term renal outcome. CONCLUSION: Long-term followup of patients from the ELNT confirms that, in lupus nephritis, a remission-inducing regimen of low-dose IV CYC followed by AZA achieves clinical results comparable with those obtained with a high-dose regimen. Early response to therapy is predictive of good long-term renal outcome.

323 citations

Journal ArticleDOI
TL;DR: Based on size, stability and release/permeation data, and considering the chemical protection of the lutein prior to its absorption into the skin, the lipid nanoparticles are potential dermal nanocarriers for lutenin.

323 citations

Journal ArticleDOI
TL;DR: Speckle tracking is a feasible technique for the assessment of longitudinal myocardial LA deformation using a 12-segment model for the left atrium.
Abstract: Background The role of speckle tracking in the assessment of left atrial (LA) deformation dynamics is not established. We sought to determine the feasibility and reference ranges of LA longitudinal strain indices measured by speckle tracking in a population of normal subjects.

323 citations

Journal ArticleDOI
TL;DR: Survition of Siewert type 2 and 3 EGJ tumors was better stratified by this IGCA stage grouping than by either esophageal or gastric scheme of AJCC7, especially among stage III subgroups.
Abstract: Background The current AJCC staging system for gastric cancer (AJCC7) incorporated several major revisions to the previous edition. The T and N categories and the stage groups were newly defined, and adenocarcinoma of the esophagogastric junction (EGJ) was reclassified and staged according to the esophageal system. Studies to validate these changes showed inconsistent results. The International Gastric Cancer Association (IGCA) launched a project to support evidence-based revisions to the next edition of the AJCC staging system.

323 citations


Authors

Showing all 12352 results

NameH-indexPapersCitations
Johan Auwerx15865395779
I. V. Gorelov1391916103133
Roberto Tenchini133139094541
Francesco Fabozzi133156193364
M. Davier1321449107642
Roberto Dell'Orso132141292792
Rino Rappuoli13281664660
Teimuraz Lomtadze12989380314
Manas Maity129130987465
Dezso Horvath128128388111
Paolo Azzurri126105881651
Vincenzo Di Marzo12665960240
Igor Katkov12597271845
Ying Lu12370862645
Thomas Schwarz12370154560
Network Information
Related Institutions (5)
University of Florence
79.5K papers, 2.3M citations

97% related

Sapienza University of Rome
155.4K papers, 4.3M citations

96% related

University of Padua
114.8K papers, 3.6M citations

95% related

University of Bologna
115.1K papers, 3.4M citations

95% related

University of Milan
139.7K papers, 4.6M citations

95% related

Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202391
2022221
20211,870
20201,979
20191,639
20181,523