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Showing papers by "University of South Australia published in 2003"


Journal ArticleDOI
TL;DR: In this paper, the authors developed a general service sector model of repurchase intention from the consumer theory literature and applied it to customers of comprehensive car insurance and personal superannuation services.
Abstract: This paper develops a general service sector model of repurchase intention from the consumer theory literature. A key contribution of the structural equation model is the incorporation of customer perceptions of equity and value and customer brand preference into an integrated repurchase intention analysis. The model describes the extent to which customer repurchase intention is influenced by seven important factors – service quality, equity and value, customer satisfaction, past loyalty, expected switching cost and brand preference. The general model is applied to customers of comprehensive car insurance and personal superannuation services. The analysis finds that although perceived quality does not directly affect customer satisfaction, it does so indirectly via customer equity and value perceptions. The study also finds that past purchase loyalty is not directly related to customer satisfaction or current brand preference and that brand preference is an intervening factor between customer satisfaction and repurchase intention. The main factor influencing brand preference was perceived value with customer satisfaction and expected switching cost having less influence.

1,456 citations


Journal ArticleDOI
TL;DR: In this paper, a detailed understanding of the sweep flocculation mechanism is provided, especially with regard to the role of charge neutralization and hydroxide precipitation. But the results can be reasonably well explained in terms of established ideas, and there are also some uncertainties regarding the action of pre-hydrolysed coagulants.

1,424 citations


Journal ArticleDOI
TL;DR: Longitudinal studies provide stronger support for the view that peer victimization is a significant causal factor in schoolchildren's lowered health and well-being and that the effects can be long-lasting.
Abstract: For the most part, studies of the consequences of bullying in schools have concentrated upon health outcomes for children persistently bullied by their peers. Conclusions have been influenced by how bullying has been conceptualized and assessed, the specific health outcomes investigated, and the research method and data analysis employed. Results from cross-sectional surveys suggest that being victimized by peers is significantly related to comparatively low levels of psychological well-being and social adjustment and to high levels of psychological distress and adverse physical health symptoms. Retrospective reports and studies suggest that peer victimization may contribute to later difficulties with health and well-being. Longitudinal studies provide stronger support for the view that peer victimization is a significant causal factor in schoolchildren's lowered health and well-being and that the effects can be long-lasting. Further evidence from longitudinal studies indicates that the tendency to bully others at school significantly predicts subsequent antisocial and violent behaviour.

634 citations


Journal ArticleDOI
TL;DR: There has been a very rapid secular decline in the 20mSRT performance of children and adolescents over the last 20 years, at least in developed countries, with a sample-weighted mean decline of 0.43% of mean values per year.
Abstract: It is widely believed that the performance of children and adolescents on aerobic fitness tests is declining. To test this hypothesis, this meta-analysis compared the results of 55 reports of the performance of children and adolescents aged 6–19 years who have used the 20m shuttle run test (20mSRT). All data were collected in the period 1981–2000. Following corrections for methodological variation, the results of all studies were expressed using the common metric of running speed (km/h) at the last completed stage. Raw data were combined with pseudodata generated from reported means and standard deviations using Monte Carlo simulation. Where data were available on children and adolescents from the same country of the same age and sex, but tested at different times, linear regression was used to calculate rates of change. This was possible for 11 (mainly developed) countries, representing a total of 129 882 children and adolescents in 151 age × sex × country slices. There has been a significant decline in performance in the 11 countries where data were available, and in most age × sex groups, with a sample-weighted mean decline of 0.43% of mean values per year. The decline was most marked in older age groups and the rate of decline was similar for boys and girls. There has been a very rapid secular decline in the 20mSRT performance of children and adolescents over the last 20 years, at least in developed countries. The rate of decline is not related to the change in the country’s relative wealth, as quantified by per capita gross domestic product (GDP).

470 citations


Journal ArticleDOI
TL;DR: The authors examined the emotional demands (emotional labour) of call centre work and their relationship to the job satisfaction and emotional exhaustion in a sample of South Australian call centre workers (N = 98) within the theoretical frameworks of the job demand, control model, effort and reward imbalance model, and the job demands, resources model.
Abstract: The rapid rise of the service sector, and in particular the call centre industry has made the study of emotional labour increasingly important within the area of occupational stress research. Given high levels of turnover and absenteeism in the industry this article examines the emotional demands (emotional labour) of call centre work and their relationship to the job satisfaction and emotional exhaustion in a sample of South Australian call centre workers (N = 98) within the theoretical frameworks of the job demand – control model, the effort – reward imbalance model, and the job demands – resources model. Qualitatively the research confirmed the central role of emotional labour variables in the experience of emotional exhaustion and satisfaction at work. Specifically the research confirmed the pre-eminence of emotional dissonance compared to a range of emotional demand variables in its potency to account for variance in emotional exhaustion and job satisfaction. Specifically, emotional dissonance mediat...

450 citations


Journal ArticleDOI
01 Dec 2003
TL;DR: Results from structure equation modeling show that repetition of favorite activities has a moderate effect upon addiction, which is in line with the assertion of rational addiction theory, but flow experience--the emotional state embracing perceptional distortion and enjoyment-- shows a much stronger impact on addiction.
Abstract: Consumer habit, an important key to repetitive consumption, is an interesting yet puzzling phenomenon. Sometimes this consumption becomes obsessive—consumers will continue to act a certain way even when they feel it is not in their best interests. However, not all consumers develop such addictions. This study uses cyber-game addiction syndrome as an analogue to trace the possible causes of consumer addiction. Results from structure equation modeling show that repetition of favorite activities has a moderate effect upon addiction, which is in line with the assertion of rational addiction theory. However, flow experience—the emotional state embracing perceptional distortion and enjoyment—shows a much stronger impact on addiction. This suggests that consumers who have experienced flow are more likely to be addicted.

427 citations


Posted Content
TL;DR: This paper investigated the structural dimensions of the South African wine industry as these specifically relate to wine route enterprises and determined the nature and extent of the wine tourism product offered on the wine route estates.
Abstract: Wine tourism has emerged as a strong and growing area of special-interest tourism in ‘New World’ wine countries in particular, and represents an increasinglysignificant component of the regional and rural tourism products of these countries. The development of wine routes throughout Europe, and increasingly in ‘New World’ wine countries, provides the link between wine and tourism. South Africa is believed to be one of the most aggressive in the short- to medium-term in getting out its wine tourism message. The twofold purpose of this paper is to investigate the structural dimensions of the South African wine industryas these specificallyrelate to wine route estates and to determine the nature and extent of the wine tourism ‘product’ offered on the wine route estates. In this context, 125 face-to-face interviews were conducted with wine route estate enterprises. Wine route estates have long recognised the potential of wine tourism and the implications of their involvement in wine tourism through their inclusion in wine routes are discussed.

402 citations


Book ChapterDOI
23 Jun 2003
TL;DR: The design principles, the basic concepts, and the underlying XML technology of PNML are discussed to stimulate discussion on and contributions to a standard Petri net interchange format.
Abstract: The Petri Net Markup Language (PNML) is an XML-based interchange format for Petri nets. In order to support different versions of Petri nets and, in particular, future versions of Petri nets, PNML allows the definition of Petri net types. Due to this flexibility, PNML is a starting point for a standard interchange format for Petri nets. This paper discusses the design principles, the basic concepts, and the underlying XML technology of PNML. The main purpose of this paper is to disseminate the ideas of PNML and to stimulate discussion on and contributions to a standard Petri net interchange format.

391 citations


Proceedings ArticleDOI
TL;DR: A remote laboratory called NetLab is presented, developed at the University of South Australia, with its specially designed graphical user interface it offers students all the advantages of a real laboratory environment.
Abstract: During the last decade the exponential expansion of the Internet has had an enormous impact on the tertiary education sector. The new technology has brought a significant improvement in communication within the academic community and has improved students' learning experiences. However, one of the most important factors in forming the engineering graduate qualities is the practical component of the engineering curriculum. Many software packages have been developed for the simulation of real experiments and although very useful, none of them are as effective as learning from undertaking real experimental work. Remote laboratories offer all the advantages of the new technology, but are often a poor replacement for real laboratory work. In this paper we present a remote laboratory called NetLab, developed at the University of South Australia. With its specially designed graphical user interface it offers students all the advantages of a real laboratory environment.

358 citations


Journal ArticleDOI
TL;DR: Current evidence shows significant short-term benefit from oral steroids, splinting, ultrasound, yoga and carpal bone mobilisation, but more trials are needed to compare treatments and ascertain the duration.
Abstract: Background Non-surgical treatment for carpal tunnel syndrome is frequently offered to those with mild to moderate symptoms. The effectiveness and duration of benefit from non-surgical treatment for carpal tunnel syndrome remain unknown. Objectives To evaluate the effectiveness of non-surgical treatment (other than steroid injection) for carpal tunnel syndrome versus a placebo or other non-surgical, control interventions in improving clinical outcome. Search methods We searched the Cochrane Neuromuscular Disease Group specialised register (searched March 2002), MEDLINE (searched January 1966 to February 7 2001), EMBASE (searched January 1980 to March 2002), CINAHL (searched January 1983 to December 2001), AMED (searched 1984 to January 2002), Current Contents (January 1993 to March 2002), PEDro and reference lists of articles. Selection criteria Randomised or quasi-randomised studies in any language of participants with the diagnosis of carpal tunnel syndrome who had not previously undergone surgical release. We considered all non-surgical treatments apart from local steroid injection. The primary outcome measure was improvement in clinical symptoms after at least three months following the end of treatment. Data collection and analysis Three reviewers independently selected the trials to be included. Two reviewers independently extracted data. Studies were rated for their overall quality. Relative risks and weighted mean differences with 95% confidence intervals were calculated for the primary and secondary outcomes in each trial. Results of clinically and statistically homogeneous trials were pooled to provide estimates of the efficacy of non-surgical treatments. Main results Twenty-one trials involving 884 people were included. A hand brace significantly improved symptoms after four weeks (weighted mean difference (WMD) -1.07; 95% confidence interval (CI) -1.29 to -0.85) and function (WMD -0.55; 95% CI -0.82 to -0.28). In an analysis of pooled data from two trials (63 participants) ultrasound treatment for two weeks was not significantly beneficial. However one trial showed significant symptom improvement after seven weeks of ultrasound (WMD -0.99; 95% CI -1.77 to - 0.21) which was maintained at six months (WMD -1.86; 95% CI -2.67 to -1.05). Four trials involving 193 people examined various oral medications (steroids, diuretics, nonsteroidal anti-inflammatory drugs) versus placebo. Compared to placebo, pooled data for two-week oral steroid treatment demonstrated a significant improvement in symptoms (WMD -7.23; 95% CI -10.31 to -4.14). One trial also showed improvement after four weeks (WMD -10.8; 95% CI -15.26 to -6.34). Compared to placebo, diuretics or nonsteroidal anti-inflammatory drugs did not demonstrate significant benefit. In two trials involving 50 people, vitamin B6 did not significantly improve overall symptoms. In one trial involving 51 people yoga significantly reduced pain after eight weeks (WMD -1.40; 95% CI -2.73 to -0.07) compared with wrist splinting. In one trial involving 21 people carpal bone mobilisation significantly improved symptoms after three weeks (WMD -1.43; 95% CI -2.19 to -0.67) compared to no treatment. In one trial involving 50 people with diabetes, steroid and insulin injections significantly improved symptoms over eight weeks compared with steroid and placebo injections. Two trials involving 105 people compared ergonomic keyboards versus control and demonstrated equivocal results for pain and function. Trials of magnet therapy, laser acupuncture, exercise or chiropractic care did not demonstrate symptom benefit when compared to placebo or control. Authors' conclusions Current evidence shows significant short-term benefit from oral steroids, splinting, ultrasound, yoga and carpal bone mobilisation. Other non-surgical treatments do not produce significant benefit. More trials are needed to compare treatments and ascertain the duration of benefit.

355 citations


Journal ArticleDOI
TL;DR: In this paper, a review of the predictions about how we will do business in the new century seems a necessary precursor to a discussion of changes in education; in the light of expected changes in business, what skills will be required by the accountants of the future?; and what are the implications for accounting education? Expected trends in business practice and the necessary skill set of accountants are reviewed in light of recent literature from the United Kingdom, United States and Australia.
Abstract: As the new century and millennium get underway it is appropriate to reflect upon, and plan for, expected changes in accounting practice and the implications of these changes for accounting education. This paper covers three broad topics. These are: • the future of business and accounting practice—a brief review of the predictions about how we will do business in the new century seems a necessary precursor to a discussion of changes in education; • in the light of expected changes in business, what skills will be required by the accountants of the future?; and • what are the implications for accounting education? Expected trends in business practice and the necessary skill set of accountants are reviewed in the light of recent literature from the United Kingdom, United States and Australia. These trends suggest that so-called ‘compliance’ work will form a diminished portion of accounting firms' revenues as technology means that even small businesses become more empowered with respect to their record-keeping needs. On the other hand, the main growth areas of accounting practice appear to lie in the fields of business advisory services. As such, future accountants will take on the role of ‘knowledge’ workers. Although a command of technology will be an important component of an accountant's skill set, of more significance will be skills in analysis, innovative problem solving, communication and client relations. Accounting educators need to anticipate the expected shift in accountants' skills and develop courses and teaching methods that are far more interdisciplinary and analytical in their orientation. This paper explores some ways in which this might be achieved and some of the challenges to effecting change in accounting education that will have to be overcome.

Journal ArticleDOI
TL;DR: The evidence for nanobubbles as the origin of the long-ranged attractions measured between hydrophobic surfaces immersed in water is reviewed by focusing upon several unique features of the force curves.

Journal ArticleDOI
TL;DR: In this paper, a model of offender treatment readiness is proposed for both assessment of offenders and for modification of low readiness, and the implications of the model for both assessing offenders and modifying low readiness.

Journal ArticleDOI
TL;DR: Obesity is associated with an increase in a broad range of fatal and non-fatal cardiovascular events, and consideration of only coronary, only fatal, and only first events greatly underestimates the cardiovascular consequences of obesity.
Abstract: Aims To examine the long-term cardiovascular consequences of obesity and project the cardiovascular consequences of the recent increase in prevalence of obesity. Methods and results Between 1972 and 1976, 15 402 individuals aged 45–64, living in two towns in the west of Scotland underwent comprehensive cardiovascular screening. We analysed all deaths and hospitalizations for cardiovascular reasons occurring over the subsequent 20 years according to baseline body mass index (BMI) category. Compared with normal weight individuals (BMI 18.5–24.9), obesity (BMI ≥30) was associated with an increased adjusted risk of coronary heart disease (hazard ratio for death or hospital admission: 1.60, 95% CI 1.45–1.78), heart failure (2.09, 1.68–2.59), stroke (1.41, 1.21–1.65), venous thrombo-embolism (2.29, 1.60–3.30), and atrial fibrillation (1.75, 1.17–2.65). Obesity was associated with nine additional cardiovascular deaths and 36 additional cardiovascular hospital admissions for every 100 affected middle-aged men over the subsequent 20 years (seven deaths and 28 admissions in women). Assuming no change in cardiovascular risk profile and outcomes related to obesity, the increase in prevalence in 1998, when compared with 1972, is projected to lead to an additional four cardiovascular deaths and 14 admissions per 100 middle-aged men and women over the next 20 years. Conclusion Obesity is associated with an increase in a broad range of fatal and non-fatal cardiovascular events. Consideration of only coronary, only fatal, and only first events greatly underestimates the cardiovascular consequences of obesity.

Proceedings ArticleDOI
09 Jul 2003
TL;DR: The results reveals that in comparison with general single-path routing protocol, multipath routing mechanism creates more overheads but provides better performance in congestion and capacity provided that the route length is within a certain upper bound which is derivable.
Abstract: Research on multipath routing protocols to provide improved throughput and route resilience as compared with single-path routing has been explored in details in the context of wired networks. However, multipath routing mechanism has not been explored thoroughly in the domain of ad hoc networks. In this paper, we analyze and compare reactive single-path and multipath routing with load balance mechanisms in ad hoc networks, in terms of overhead, traffic distribution and connection throughput. The results reveals that in comparison with general single-path routing protocol, multipath routing mechanism creates more overheads but provides better performance in congestion and capacity provided that the route length is within a certain upper bound which is derivable. The analytical results are further confirmed by simulation.

Journal ArticleDOI
TL;DR: In this paper, the formation of very small gas bubbles (so-called "nanobubbles") at structured solid−water interfaces has been studied using the tapping mode atomic force microscopy (TMAFM) imaging technique.
Abstract: The formation of very small gas bubbles (so-called “nanobubbles”) at structured solid−water interfaces has been studied using the tapping mode atomic force microscopy (TMAFM) imaging technique. Silicon oxide wafer surfaces were prepared with different degrees of nanometer scale surface roughness and hydrophobicity. Small bubbles do not form on smooth, hydrophilic, or dehydroxylated silicon oxide wafer surfaces immersed in aqueous solutions under known levels of gas supersaturation. Randomly distributed small bubbles were observed over the whole surface of observation on methylated surfaces of controlled roughness. Bubbles formed on rough, methylated surfaces were larger and less-densely distributed than those on a smooth surface of similar hydrophobicity. The process of bubble coalescence was observed as a function of time. The macroscopic contact angle, measured with respect to the aqueous or gas phase, is very different from the microscopic contact angle detected by TMAFM and appears to be due to the in...

Journal ArticleDOI
TL;DR: There is consistent evidence that the likelihood of working in rural practice is approximately twice greater among doctors with a rural background, and there is a smaller body of evidence in support of the other rural factors studied.
Abstract: Objective: We sought to summarise the evidence for an association between rural background and rural practice by systematically reviewing the national and international published reports. Design: A systematic review. Setting: A search of the national and international published reports from 1973 to October 2001. Subject: The search criteria included observational studies of a case-control or cohort design making a clear and quantitative comparison between current rural and urban doctors, this resulted in the identification of 141 studies for potential inclusion. Results: We systematically reviewed 12 studies. Rural background was associated with rural practice in 10 of the 12 studies, in which it was reported, with most odds ratios (OR) approximately 2–2.5. Rural schooling was associated with rural practice in all 5 studies that reported on it, with most OR approximately 2.0. Having a rural partner was associated with rural practice in 3 of the 4 studies reporting on it, with OR approximately 3.0. Rural undergraduate training was associated with rural practice in 4 of 5 studies, with most OR approximately 2.0. Rural postgraduate training was associated with rural practice in 1 of 2 studies, with rural doctors reporting rural training about 2.5 times more often. Conclusions: There is consistent evidence that the likelihood of working in rural practice is approximately twice greater among doctors with a rural background. There is a smaller body of evidence in support of the other rural factors studied, and the strength of association is similar to that for rural background. What is already known on this subject?: It is widely perceived that doctors with a rural background are more likely to return to work in rural areas and major policy initiatives in Australia rely on this assumption. It is recognised that other factors such as location of primary and secondary education, rural medical training and spouse or partner background may also be influential. In order to determine the strength of the evidence for an association between rural background and rural practice we did a systematic review of the published reports. What does this study add?: This systematic review provides good evidence that doctors with a rural background are about twice as likely to work as rural doctors, compared with those with an urban background. Rural background seems to be an important factor that can be employed in policy and practice, however, the problem of increasing the number of rural doctors is multifactorial and so is the solution.

Journal ArticleDOI
TL;DR: The renal clearance of L-carnitine increases after exogenous administration, approaching GFR after high intravenous doses, and many forms of secondary carnitine deficiency, including some drug-induced disorders, arise from impaired renal tubular re absorption.
Abstract: L-Carnitine is a naturally occurring compound that facilitates the transport of fatty acids into mitochondria for beta-oxidation. Exogenous L-carnitine is used clinically for the treatment of carnitine deficiency disorders and a range of other conditions. In humans, the endogenous carnitine pool, which comprises free L-carnitine and a range of short-, medium- and long-chain esters, is maintained by absorption of L-carnitine from dietary sources, biosynthesis within the body and extensive renal tubular reabsorption from glomerular filtrate. In addition, carrier-mediated transport ensures high tissue-to-plasma concentration ratios in tissues that depend critically on fatty acid oxidation. The absorption of L-carnitine after oral administration occurs partly via carrier-mediated transport and partly by passive diffusion. After oral doses of 1-6g, the absolute bioavailability is 5-18%. In contrast, the bioavailability of dietary L-carnitine may be as high as 75%. Therefore, pharmacological or supplemental doses of L-carnitine are absorbed less efficiently than the relatively smaller amounts present within a normal diet.L-Carnitine and its short-chain esters do not bind to plasma proteins and, although blood cells contain L-carnitine, the rate of distribution between erythrocytes and plasma is extremely slow in whole blood. After intravenous administration, the initial distribution volume of L-carnitine is typically about 0.2-0.3 L/kg, which corresponds to extracellular fluid volume. There are at least three distinct pharmacokinetic compartments for L-carnitine, with the slowest equilibrating pool comprising skeletal and cardiac muscle.L-Carnitine is eliminated from the body mainly via urinary excretion. Under baseline conditions, the renal clearance of L-carnitine (1-3 mL/min) is substantially less than glomerular filtration rate (GFR), indicating extensive (98-99%) tubular reabsorption. The threshold concentration for tubular reabsorption (above which the fractional reabsorption begins to decline) is about 40-60 micromol/L, which is similar to the endogenous plasma L-carnitine level. Therefore, the renal clearance of L-carnitine increases after exogenous administration, approaching GFR after high intravenous doses. Patients with primary carnitine deficiency display alterations in the renal handling of L-carnitine and/or the transport of the compound into muscle tissue. Similarly, many forms of secondary carnitine deficiency, including some drug-induced disorders, arise from impaired renal tubular reabsorption. Patients with end-stage renal disease undergoing dialysis can develop a secondary carnitine deficiency due to the unrestricted loss of L-carnitine through the dialyser, and L-carnitine has been used for treatment of some patients during long-term haemodialysis. Recent studies have started to shed light on the pharmacokinetics of L-carnitine when used in haemodialysis patients.

Journal ArticleDOI
TL;DR: It is argued that an important impediment to the future success of anger management is the failure to fully address the issue of treatment readiness, which requires greater attention to the measurement and analysis of readiness.

Journal ArticleDOI
TL;DR: In this article, the influence of an anionic polyacrylamide-acrylate copolymer (PAM) and a nonionic polyethylene oxide (PEO) polymer on the surface chemistry, shear yield stress, settling rates and consolidation behavior of kaolinite dispersions has been investigated at pH 7.5.

Journal ArticleDOI
TL;DR: Raw and potable water analysis revealed that DVC and culture-based techniques reported significantly fewer viable bacteria compared to the number of physiologically active bacteria detected using the rapid FCM assays, where this difference appeared to be nonlinear across different samples.

Book ChapterDOI
TL;DR: A review of the current literature indicates that extensive research has been performed on the speciation of Cr in soil, the effect of pH on soil solution concentrations of Cr(III) and Cr(VI), soil adsorption phenomenon of Cr species, redox reactions, and transformation of Cr-contaminated soils together with remediation strategies to decontaminate Cr-containing soils.
Abstract: Worldwide chromium contamination of soils has arisen predominantly from the common practice of land-based disposal of tannery wastes under the assumption that the dominant species in the tannery waste would be the thermodynamically stable Cr(III) species. However, significant levels of toxic Cr(VI) recently detected in surface water and groundwater in India, China, Australia, and elsewhere raise critical questions relating to current disposal criteria for Cr-containing wastes. It now appears that despite the thermodynamic stability of Cr(III), the presence of certain naturally occurring minerals, especially Mn oxides, can enhance oxidation of Cr(III) to Cr(VI) in the soil environment. This factor is of public concern because at high pH, Cr(VI) is bioavailable, and it is this form that is highly mobile and therefore poses the greatest risk of groundwater contamination.

Journal ArticleDOI
TL;DR: The stability of a fourth source of CMS in Mueller-Hinton broth examined during 30 min at 37°C revealed no formation of colistin, suggesting that different sulfomethyl CMSs possess intrinsic antibacterial activity.
Abstract: The stabilities of colistin and colistin methanesulfonate (CMS) in different aqueous media were studied by specific high-performance liquid chromatography (HPLC) methods. Colistin was stable in water at 4 and 37°C for up to 60 days and 120 h, respectively. However, degradation was observed when colistin was stored in isotonic phosphate buffer (0.067 M, pH 7.4) and human plasma at 37°C. The stability of CMS from three different sources in water was explored by strong-anion-exchange (SAX) HPLC for CMS and by measuring the concentrations of colistin formed from the hydrolysis of CMS. The peaks of CMS in SAX HPLC disappeared almost completely after 12 h at 37°C, but appeared to remain intact for up to 2 days at 4°C. Over the same period, there was no formation of colistin at 4°C. In water, phosphate buffer, and plasma, there was rapid formation of colistin within 24 to 48 h at 37°C from the three sources of CMS. The hydrolysis products were assumed to be a complex mixture of many different sulfomethyl derivatives, including colistin. The stability of a fourth source of CMS in Mueller-Hinton broth examined during 30 min at 37°C revealed no formation of colistin. Along with previous microbiological studies, this suggested that different sulfomethyl CMSs possess intrinsic antibacterial activity. These results will be helpful for understanding the pharmacokinetics and pharmacodynamics of colistin and CMS in humans and animals.

Journal ArticleDOI
TL;DR: An analytical model that enables the calculation of the flotation rate constant of particles as a function of particle size with, as input parameters, measurable particle, bubble, and hydrodynamic quantities has been derived and it is demonstrated that it depends mainly on the relative magnitude of particle contact angle and turbulent dissipation energy.

Journal ArticleDOI
TL;DR: The association between rural undergraduate training, rural postgraduate training and medical school entry criteria favouring rural students, on likelihood of working in rural Australian general practice is studied.
Abstract: Objective To determine the association between rural undergraduate training, rural postgraduate training and medical school entry criteria favouring rural students, on likelihood of working in rural Australian general practice. Methods National case - control study of 2414 rural and urban general practitioners (GPs) sampled from the Health Insurance Commission database. Participants completed a questionnaire providing information on demographics, current practice location and rural undergraduate and postgraduate experience. Results Rural GPs were more likely to report having had any rural undergraduate training [ odds ratio ( OR) 1.61, 95% confidence interval (CI) 1.32 - 1.95] than were urban GPs. Rural GPs were much more likely to report having had rural postgraduate training ( OR 3.14, 95% CI 2.57 - 3.83). As the duration of rural postgraduate training increased so did the likelihood of working as a rural GP: those reporting that more than half their postgraduate training was rural were most likely to be rural GPs ( OR 10.52, 95% CI 5.39 - 20.51). South Australians whose final high school year was rural were more likely to be rural GPs ( OR 3.18, 95% CI 0.99 - 10.22). Conclusions Undergraduate rural training, postgraduate training and medical school entry criteria favouring rural students, all are associated with an increased likelihood of being a rural GP. Longer rural postgraduate training is more strongly associated with rural practice. These findings argue for continuation of rural undergraduate training opportunities and rural entry schemes, and an expansion in postgraduate training opportunities for GPs.

Journal ArticleDOI
TL;DR: This study compared body composition by dual-energy X-ray absorptiometry (DEXA; Lunar DPX-L) with that via a four-compartment (4C; water, bone mineral mass, fat, and residual) model with a significantly (P < 0.001) higher mean %BF compared with DEXA.
Abstract: This study compared body composition by dual-energy X-ray absorptiometry (DEXA; Lunar DPX-L) with that via a four-compartment (4C; water, bone mineral mass, fat, and residual) model. Relative body fat was determined for 152 healthy adults [30.0 +/- 11.1 (SD) yr; 75.10 +/- 14.88 kg; 176.3 +/- 8.7 cm] aged from 18 to 59 yr. The 4C approach [20.7% body fat (%BF)] resulted in a significantly (P < 0.001) higher mean %BF compared with DEXA (18.9% BF), with intraindividual variations ranging from -2.6 to 7.3% BF. Linear regression and a Bland and Altman plot demonstrated the tendency for DEXA to progressively underestimate the %BF of leaner individuals compared with the criterion 4C model (4C %BF = 0.862 x DEXA %BF + 4.417; r(2) = 0.952, standard error of estimate = 1.6% BF). This bias was not attributable to variations in fat-free mass hydration but may have been due to beam-hardening errors that resulted from differences in anterior-posterior tissue thickness.

Journal ArticleDOI
TL;DR: Based on the in vitro pharmacodynamics against Pseudomonas aeruginosa previously published by this group and these pharmacokinetic findings, dose escalating trials may be warranted to maximize efficacy.
Abstract: OBJECTIVES To define the steady-state pharmacokinetics of colistin methanesulphonate and colistin in patients with cystic fibrosis (CF) following intravenous administration of the former. MATERIALS AND METHODS The study was conducted in 12 patients with CF following intravenous administration of colistin methanesulphonate (1.63-3.11 mg/kg) every 8 h for at least 2 days. On the day of study, four blood samples were collected from each patient at 60, 120, 240 and 360 min after the end of the infusion. Concentrations of colistin methanesulphonate and colistin in plasma were measured separately by HPLC. RESULTS At steady-state, colistin methanesulphonate had a mean (+/- S.D.) total body clearance, volume of distribution and half-life of 2.01 +/- 0.46 mL/min per kg, 340 +/- 95 mL/kg and 124 +/- 52 min, respectively. Colistin had a significantly longer mean half-life of 251 +/- 79 min (P<0.001). With the regimen used, colistin methanesulphonate was well tolerated. This is the first report on the pharmacokinetics of colistin methanesulphonate in CF patients determined using concentrations of colistin methanesulphonate and colistin in plasma. CONCLUSIONS Based on the in vitro pharmacodynamics against Pseudomonas aeruginosa previously published by our group and these pharmacokinetic findings, dose escalating trials may be warranted to maximize efficacy.

01 Jan 2003
TL;DR: This article explored the perceptions of final year university business students of their formal group work experiences and found that group work has many benefits for effective learning while also preparing graduates for future work, however, group work often elicits a mixed reception from participants.
Abstract: Group work has many benefits for effective learning while also preparing graduates for future work. However, group work often elicits a mixed reception from participants. This paper explores the perceptions of final year university business students of their formal group work experiences. Information has been gathered through the collection of quantitative and qualitative data, and analysis reveals student experiences, both positive and negative. This paper also examines students’ perceptions about the extent to which their experiences enabled them to achieve the university’s graduate group work competencies. Finally, it reports students’ own suggestions for improving the problems they encountered thus providing strategies for addressing their concerns. university, groupwork, perceptions, free-riding, education

Journal ArticleDOI
TL;DR: None of the tested measures exhibited adequate reliability in young children, and, with less-than-desirable reliability being demonstrated, most measures need to be interpreted accordingly when repeated measures are involved.
Abstract: Repeatable measures are essential for clinicians and researchers alike. Both need baseline measures that are reliable, as intervention effects cannot be accurately identified without consistent measures. The intrarater and interrater reliability of the new Foot Posture Index and current podiatric measures of foot position were assessed using a same-subject, repeated-measures study design across three age groups. The Foot Posture Index total score showed moderate reliability overall, demonstrating better reliability than most other current measures, although navicular height (normalized for foot length) was the single most reliable measure in adults. None of the tested measures exhibited adequate reliability in young children, and, with less-than-desirable reliability being demonstrated, most measures need to be interpreted accordingly when repeated measures are involved.

Journal ArticleDOI
TL;DR: Routine incorporation of beta-glucan preparations like EcoActivaduring winter may enhance macrophage function and growth rates at a time of increased disease susceptibility and little or no growth.