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Institution

University of South Australia

EducationAdelaide, South Australia, Australia
About: University of South Australia is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 10086 authors who have published 32587 publications receiving 913683 citations. The organization is also known as: The University of South Australia & UniSA.


Papers
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Journal ArticleDOI
TL;DR: There may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomized controlled trials are required to confirm the potential benefits of vitamin D supplements in this population.
Abstract: Vitamin D deficiency is common in women with polycystic ovary syndrome (PCOS), with the 67-85% of women with PCOS having serum concentrations of 25-hydroxy vitamin D (25OHD) <20 ng/ml. Vitamin D deficiency may exacerbate symptoms of PCOS, with observational studies showing lower 25OHD levels were associated with insulin resistance, ovulatory and menstrual irregularities, lower pregnancy success, hirsutism, hyperandrogenism, obesity and elevated cardiovascular disease risk factors. There is some, but limited, evidence for beneficial effects of vitamin D supplementation on menstrual dysfunction and insulin resistance in women with PCOS. Vitamin D deficiency may play a role in exacerbating PCOS, and there may be a place for vitamin D supplementation in the management of this syndrome, but current evidence is limited and additional randomized controlled trials are required to confirm the potential benefits of vitamin D supplementation in this population.

238 citations

Journal ArticleDOI
TL;DR: Findings show that mutations in PRRT2 cause both epilepsy and a movement disorder, and elicit pleiotropy in terms of both age of expression and anatomical substrate (cortex versus basal ganglia).
Abstract: Benign familial infantile epilepsy (BFIE) is a self-limited seizure disorder that occurs in infancy and has autosomal-dominant inheritance. We have identified heterozygous mutations in PRRT2, which encodes proline-rich transmembrane protein 2, in 14 of 17 families (82%) affected by BFIE, indicating that PRRT2 mutations are the most frequent cause of this disorder. We also report PRRT2 mutations in five of six (83%) families affected by infantile convulsions and choreoathetosis (ICCA) syndrome, a familial syndrome in which infantile seizures and an adolescent-onset movement disorder, paroxysmal kinesigenic choreoathetosis (PKC), co-occur. These findings show that mutations in PRRT2 cause both epilepsy and a movement disorder. Furthermore, PRRT2 mutations elicit pleiotropy in terms of both age of expression (infancy versus later childhood) and anatomical substrate (cortex versus basal ganglia).

238 citations

Journal ArticleDOI
01 Aug 2013-Carbon
TL;DR: In this article, single-walled carbon nanotubes were combined with graphene oxide nanosheets in aqueous dispersion and then chemically reduced to form the Carbon Nanotube/graphene (CNT/G) composite as electrodes for capacitive deionization (CDI).

238 citations

Journal ArticleDOI
01 Aug 2016-Carbon
TL;DR: Graphene (Gr)-based materials are a promising nanomaterial for the development of antibacterial surfaces owing to their biocidal activity as mentioned in this paper, however, the effect of the physicochemical features of these materials on their antibacterial activity has yet to be clarified.

237 citations

Journal ArticleDOI
Nicola Barban1, Rick Jansen2, Ronald de Vlaming3, Ahmad Vaez4  +281 moreInstitutions (83)
TL;DR: In this article, the authors reported a large genome-wide association study of both sexes including 251,151 individuals for AB and 343,072 individuals for NEB and identified 12 independent loci that are significantly associated with AB and NEB.
Abstract: The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood We report a large genome-wide association study of both sexes including 251,151 individuals for AFB and 343,072 individuals for NEB We identified 12 independent loci that are significantly associated with AFB and/or NEB in a SNP-based genome-wide association study and 4 additional loci associated in a gene-based effort These loci harbor genes that are likely to have a role, either directly or by affecting non-local gene expression, in human reproduction and infertility, thereby increasing understanding of these complex traits

237 citations


Authors

Showing all 10298 results

NameH-indexPapersCitations
Andrew P. McMahon16241590650
Timothy P. Hughes14583191357
Jeremy K. Nicholson14177380275
Peng Shi137137165195
Daniel Thomas13484684224
Jian Li133286387131
Matthew Jones125116196909
Ulrich S. Schubert122222985604
Elaine Holmes11956058975
Arne Astrup11486668877
Richard Gray10980878580
John B. Furness10359737668
Thomas J. Jentsch10123832810
Ben W.J. Mol101148547733
John C. Lindon9948844063
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202393
2022306
20212,326
20202,175
20192,151
20182,045