University of South Australia

About: University of South Australia is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 10086 authors who have published 32587 publications receiving 913683 citations. The organization is also known as: The University of South Australia & UniSA.

What Is Stochastic Resonance? Definitions, Misconceptions, Debates, and Its Relevance to Biology

Abstract: Stochastic resonance is said to be observed when increases in levels of unpredictable fluctuations— e.g., random noise—cause an increase in a metric of the quality of signal transmission or detection performance, rather than a decrease. This counterintuitive effect relies on system nonlinearities and on some parameter ranges being ''suboptimal''. Stochastic resonance has been observed, quantified, and described in a plethora of physical and biological systems, including neurons. Being a topic of widespread multidisciplinary interest, the definition of stochastic resonance has evolved significant- ly over the last decade or so, leading to a number of debates, misunderstandings, and controversies. Perhaps the most important debate is whether the brain has evolved to utilize random noise in vivo, as part of the ''neural code''. Surprisingly, this debate has been for the most part ignored by neuroscientists, despite much indirect evidence of a positive role for noise in the brain. We explore some of the reasons for this and argue why it would be more surprising if the brain did not exploit randomness provided by noise—via stochastic resonance or otherwise—than if it did. We also challenge neurosci- entists and biologists, both computational and experi- mental, to embrace a very broad definition of stochastic resonance in terms of signal-processing ''noise benefits'', and to devise experiments aimed at verifying that random variability can play a functional role in the brain, nervous system, or other areas of biology.

European LeukemiaNet 2020 recommendations for treating chronic myeloid leukemia

Abstract: The therapeutic landscape of chronic myeloid leukemia (CML) has profoundly changed over the past 7 years. Most patients with chronic phase (CP) now have a normal life expectancy. Another goal is achieving a stable deep molecular response (DMR) and discontinuing medication for treatment-free remission (TFR). The European LeukemiaNet convened an expert panel to critically evaluate and update the evidence to achieve these goals since its previous recommendations. First-line treatment is a tyrosine kinase inhibitor (TKI; imatinib brand or generic, dasatinib, nilotinib, and bosutinib are available first-line). Generic imatinib is the cost-effective initial treatment in CP. Various contraindications and side-effects of all TKIs should be considered. Patient risk status at diagnosis should be assessed with the new EUTOS long-term survival (ELTS)-score. Monitoring of response should be done by quantitative polymerase chain reaction whenever possible. A change of treatment is recommended when intolerance cannot be ameliorated or when molecular milestones are not reached. Greater than 10% BCR-ABL1 at 3 months indicates treatment failure when confirmed. Allogeneic transplantation continues to be a therapeutic option particularly for advanced phase CML. TKI treatment should be withheld during pregnancy. Treatment discontinuation may be considered in patients with durable DMR with the goal of achieving TFR.

Predicting user acceptance of collaborative technologies: An extension of the technology acceptance model for e-learning

Abstract: Collaborative technologies support group work in project-based environments. In this study, we enhance the technology acceptance model to explain the factors that influence the acceptance of Google Applications for collaborative learning. The enhanced model was empirically evaluated using survey data collected from 136 students enrolled in a full-time degree program that used Google Applications to support project work. According to the research results, determinants of the technology acceptance model are the major factors influencing the adoption of the technology. In addition, the subjective norm represented by peers is found to significantly moderate the relationship between attitude and intention toward the technology. However, our results do not show a significant effect of subjective norms represented by instructors and mass media on students' intentions to use the technology. The ability to share information in the collaborative learning environment is found to influence intention and behavior toward the Google Applications platform.

The Value of Coastal Wetlands for Hurricane Protection

Abstract: Coastal wetlands reduce the damaging effects of hurricanes on coastal communities. A regression model using 34 major US hurricanes since 1980 with the natural log of damage per unit gross domestic product in the hurricane swath as the dependent variable and the natural logs of wind speed and wetland area in the swath as the independent variables was highly significant and explained 60% of the variation in relative damages. A loss of 1 ha of wetland in the model corresponded to an average USD 33 000 (median ¼ USD 5000) increase in storm damage from specific storms. Using this relationship, and taking into account the annual probability of hits by hurricanes of varying intensities, we mapped the annual value of coastal wetlands by 1km 3 1km pixel and by state. The annual value ranged from USD 250 to USD 51 000 ha � 1 yr � 1 , with a mean of USD 8240 ha � 1 yr � 1 (median ¼ USD 3230 ha � 1 yr � 1 ) significantly larger than previous estimates. Coastal wetlands in the US were estimated to currently provide USD 23.2 billion yr � 1 in storm protection services. Coastal wetlands function as valuable, selfmaintaining ‘‘horizontal levees’’ for storm protection, and also provide a host of other ecosystem services that vertical levees do not. Their restoration and preservation is an extremely cost-effective strategy for society.