University of South Australia

About: University of South Australia is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Context (language use). The organization has 10086 authors who have published 32587 publications receiving 913683 citations. The organization is also known as: The University of South Australia & UniSA.

Basic concepts in population modeling, simulation, and model-based drug development-part 2: introduction to pharmacokinetic modeling methods.

Abstract: Population pharmacodynamic (PD) models describe the time course of drug effects, relating exposure to response, and providing a more robust understanding of drug action than single assessments PD models can test alternative dose regimens through simulation, allowing for informed assessment of potential dose regimens and study designs This is the third paper in a three-part series, providing an introduction into methods for developing and evaluating population PD models Example files are available in the Supplementary Data

RNA in cancer.

Abstract: While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematically altered in cancer. Mutations in RNA splicing factor genes and the shortening of 3' untranslated regions are widely observed. Moreover, evidence is accumulating that other types of RNAs, including circular RNAs, can contribute to tumorigenesis. In this Review, we highlight how altered processing or activity of coding and non-coding RNAs contributes to cancer. We introduce the regulation of gene expression by coding and non-coding RNA and discuss both established roles (microRNAs and long non-coding RNAs) and emerging roles (selective mRNA processing and circular RNAs) for RNAs, highlighting the potential mechanisms by which these RNA subtypes contribute to cancer. The widespread alteration of coding and non-coding RNA demonstrates that altered RNA biogenesis contributes to multiple hallmarks of cancer.

Effects of Travel Motivation, Past Experience, Perceived Constraint, and Attitude on Revisit Intention

Abstract: This study developed and tested a structural model in examining the effects of mainland Chinese visitors' travel motivation, past experience, perceived constraint, and attitude on their intention of revisiting Hong Kong. Data were collected through telephone interviews (n = 501) in Beijing and analyzed using structural equation modeling. Findings indicate that one of travel motivation's underlying dimensions, shopping, positively affected Beijing tourists' revisit intention to Hong Kong; past experience, as measured by the number of prior visits and satisfaction, also positively influenced revisit intention. Disinterest was the only constraint factor significantly negating revisit intention. In addition, attitude was found to play a significant mediating role in the total effect of satisfaction on revisit intention. Results suggest that in addition to further strengthening Hong Kong's “shopping paradise” image, destination marketers and managers should promote more novel features of local attractions and ...

Images of nanobubbles on hydrophobic surfaces and their interactions.

Abstract: Imaging of hydrophobic surfaces in water with tapping mode atomic force microscopy reveals them to be covered with soft domains, apparently nanobubbles, that are close packed and irregular in cross section, have a radius of curvature of the order of 100 nm, and a height above the substrate of 20-30 nm. Complementary force measurements show features seen in previous measurements of the long-range hydrophobic attraction, including a jump into a soft contact and a prejump repulsion. The distance of the jump is correlated with the height of the images. The morphology of the nanobubbles and the time scale for their formation suggest the origin of their stability.

Cost of an emerging epidemic: an economic analysis of atrial fibrillation in the UK

Abstract: Objective: To evaluate the cost of atrial fibrillation (AF) to health and social services in the UK in 1995 and, based on epidemiological trends, to project this estimate to 2000. Design, setting, and main outcome measures: Contemporary estimates of health care activity related to AF were applied to the whole population of the UK on an age and sex specific basis for the year 1995. The activities considered (and costs calculated) were hospital admissions, outpatient consultations, general practice consultations, and drug treatment (including the cost of monitoring anticoagulant treatment). By adjusting for the progressive aging of the British population and related increases in hospital admissions, the cost of AF was also projected to the year 2000. Results: There were 534 000 people with AF in the UK during 1995. The “direct” cost of health care for these patients was £244 million (~€350 million) or 0.62% of total National Health Service (NHS) expenditure. Hospitalisations and drug prescriptions accounted for 50% and 20% of this expenditure, respectively. Long term nursing home care after hospital admission cost an additional £46.4 million (~€66 million). The direct cost of AF rose to £459 million (~€655 million) in 2000, equivalent to 0.97% of total NHS expenditure based on 1995 figures. Nursing home costs rose to £111 million (~€160 million). Conclusions: AF is an extremely costly public health problem.