University of South Australia

About: University of South Australia is a education organization based out in Adelaide, South Australia, Australia. It is known for research contribution in the topics: Population & Poison control. The organization has 10086 authors who have published 32587 publications receiving 913683 citations. The organization is also known as: The University of South Australia & UniSA.

The efficacy of playing a virtual reality game in modulating pain for children with acute burn injuries: A randomized controlled trial [ISRCTN87413556]

Abstract: The management of burn injuries is reported as painful, distressing and a cause of anxiety in children and their parents Child's and parents' pain and anxiety, often contributes to extended time required for burns management procedures, in particular the process of changing dressings The traditional method of pharmacologic analgesia is often insufficient to cover the burnt child's pain, and it can have deleterious side effects [1, 2] Intervention with Virtual Reality (VR) games is based on distraction or interruption in the way current thoughts, including pain, are processed by the brain Research on adults supports the hypothesis that virtual reality has a positive influence on burns pain modulation This study investigates whether playing a virtual reality game, decreases procedural pain in children aged 5–18 years with acute burn injuries The paper reports on the findings of a pilot study, a randomised trial, in which seven children acted as their own controls though a series of 11 trials Outcomes were pain measured using the self-report Faces Scale and findings of interviews with parent/carer and nurses The average pain scores (from the Faces Scale) for pharmacological analgesia only was, 41 (SD 29), while VR coupled with pharmacological analgesia, the average pain score was 13 (SD 18) The study provides strong evidence supporting VR based games in providing analgesia with minimal side effects and little impact on the physical hospital environment, as well as its reusability and versatility, suggesting another option in the management of children's acute pain

The allosteric inhibitor ABL001 enables dual targeting of BCR–ABL1

Abstract: Chronic myeloid leukaemia (CML) is driven by the activity of the BCR-ABL1 fusion oncoprotein. ABL1 kinase inhibitors have improved the clinical outcomes for patients with CML, with over 80% of patients treated with imatinib surviving for more than 10 years. Second-generation ABL1 kinase inhibitors induce more potent molecular responses in both previously untreated and imatinib-resistant patients with CML. Studies in patients with chronic-phase CML have shown that around 50% of patients who achieve and maintain undetectable BCR-ABL1 transcript levels for at least 2 years remain disease-free after the withdrawal of treatment. Here we characterize ABL001 (asciminib), a potent and selective allosteric ABL1 inhibitor that is undergoing clinical development testing in patients with CML and Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukaemia. In contrast to catalytic-site ABL1 kinase inhibitors, ABL001 binds to the myristoyl pocket of ABL1 and induces the formation of an inactive kinase conformation. ABL001 and second-generation catalytic inhibitors have similar cellular potencies but distinct patterns of resistance mutations, with genetic barcoding studies revealing pre-existing clonal populations with no shared resistance between ABL001 and the catalytic inhibitor nilotinib. Consistent with this profile, acquired resistance was observed with single-agent therapy in mice; however, the combination of ABL001 and nilotinib led to complete disease control and eradicated CML xenograft tumours without recurrence after the cessation of treatment.

Amygdala Responses to Fearful and Happy Facial Expressions under Conditions of Binocular Suppression

Abstract: The human amygdala plays a crucial role in processing affective information conveyed by sensory stimuli. Facial expressions of fear and anger, which both signal potential threat to an observer, result in significant increases in amygdala activity, even when the faces are unattended or presented briefly and masked. It has been suggested that afferent signals from the retina travel to the amygdala via separate cortical and subcortical pathways, with the subcortical pathway underlying unconscious processing. Here we exploited the phenomenon of binocular rivalry to induce complete suppression of affective face stimuli presented to one eye. Twelve participants viewed brief, rivalrous visual displays in which a fearful, happy, or neutral face was presented to one eye while a house was presented simultaneously to the other. We used functional magnetic resonance imaging to study activation in the amygdala and extrastriate visual areas for consciously perceived versus suppressed face and house stimuli. Activation within the fusiform and parahippocampal gyri increased significantly for perceived versus suppressed faces and houses, respectively. Amygdala activation increased bilaterally in response to fearful versus neutral faces, regardless of whether the face was perceived consciously or suppressed because of binocular rivalry. Amygdala activity also increased significantly for happy versus neutral faces, but only when the face was suppressed. This activation pattern suggests that the amygdala has a limited capacity to differentiate between specific facial expressions when it must rely on information received via a subcortical route. We suggest that this limited capacity reflects a tradeoff between specificity and speed of processing.

XPS of sulphide mineral surfaces: metal‐deficient, polysulphides, defects and elemental sulphur

Abstract: This paper reviews evidence for the assignments of components of the S 2p XPS spectra from sulphide mineral surfaces under different conditions of preparation, oxidation and reaction. Evidence from other techniques confirming assignment of high-binding-energy S 2p components to metal-deficient sulphide surfaces, polysulphides, elemental sulphur and electronic defect structures is considered for specific cases. Reliable assignment of S 2p 3/2 components at 163.6-164.0 eV to elemental sulphur S n 0 can be confirmed by evaporative loss at 295 K and/or observation of S-S bonding by x-ray absorption fine structure (XAFS), x-ray diffraction or vibrational spectroscopy. Assignment to polysulphides S n 2- at 162.0-163.6 eV requires confirmation of S-S bonding by XAFS or vibrational spectroscopy. Metal-deficient lattices can be represented as electronic defects (e.g. vacancies) or restructured surface phases confirmed by diffraction or XAFS evidence. High-binding-energy S 2p 3/2 components can also result from Cu(I) substitution into ZnS with associated oxidation of sulphur as electronic defect sites without S-S bonding, metal deficiency or restructuring. This assignment is confirmed by XAFS evidence.