University of Southampton

About: University of Southampton is a education organization based out in Southampton, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 37184 authors who have published 99400 publications receiving 3462915 citations. The organization is also known as: Southampton University & Soton Uni.

GW170817: observation of gravitational waves from a binary neutron star inspiral

Abstract: On August 17, 2017 at 12∶41:04 UTC the Advanced LIGO and Advanced Virgo gravitational-wave detectors made their first observation of a binary neutron star inspiral. The signal, GW170817, was detected with a combined signal-to-noise ratio of 32.4 and a false-alarm-rate estimate of less than one per 8.0×10^{4} years. We infer the component masses of the binary to be between 0.86 and 2.26 M_{⊙}, in agreement with masses of known neutron stars. Restricting the component spins to the range inferred in binary neutron stars, we find the component masses to be in the range 1.17-1.60 M_{⊙}, with the total mass of the system 2.74_{-0.01}^{+0.04}M_{⊙}. The source was localized within a sky region of 28 deg^{2} (90% probability) and had a luminosity distance of 40_{-14}^{+8} Mpc, the closest and most precisely localized gravitational-wave signal yet. The association with the γ-ray burst GRB 170817A, detected by Fermi-GBM 1.7 s after the coalescence, corroborates the hypothesis of a neutron star merger and provides the first direct evidence of a link between these mergers and short γ-ray bursts. Subsequent identification of transient counterparts across the electromagnetic spectrum in the same location further supports the interpretation of this event as a neutron star merger. This unprecedented joint gravitational and electromagnetic observation provides insight into astrophysics, dense matter, gravitation, and cosmology.

Sarcopenia: Revised European consensus on definition and diagnosis

Abstract: Background in 2010, the European Working Group on Sarcopenia in Older People (EWGSOP) published a sarcopenia definition that aimed to foster advances in identifying and caring for people with sarcopenia. In early 2018, the Working Group met again (EWGSOP2) to update the original definition in order to reflect scientific and clinical evidence that has built over the last decade. This paper presents our updated findings. Objectives to increase consistency of research design, clinical diagnoses and ultimately, care for people with sarcopenia. Recommendations sarcopenia is a muscle disease (muscle failure) rooted in adverse muscle changes that accrue across a lifetime; sarcopenia is common among adults of older age but can also occur earlier in life. In this updated consensus paper on sarcopenia, EWGSOP2: (1) focuses on low muscle strength as a key characteristic of sarcopenia, uses detection of low muscle quantity and quality to confirm the sarcopenia diagnosis, and identifies poor physical performance as indicative of severe sarcopenia; (2) updates the clinical algorithm that can be used for sarcopenia case-finding, diagnosis and confirmation, and severity determination and (3) provides clear cut-off points for measurements of variables that identify and characterise sarcopenia. Conclusions EWGSOP2's updated recommendations aim to increase awareness of sarcopenia and its risk. With these new recommendations, EWGSOP2 calls for healthcare professionals who treat patients at risk for sarcopenia to take actions that will promote early detection and treatment. We also encourage more research in the field of sarcopenia in order to prevent or delay adverse health outcomes that incur a heavy burden for patients and healthcare systems.

Kernel Methods for Pattern Analysis

Abstract: Kernel methods provide a powerful and unified framework for pattern discovery, motivating algorithms that can act on general types of data (e.g. strings, vectors or text) and look for general types of relations (e.g. rankings, classifications, regressions, clusters). The application areas range from neural networks and pattern recognition to machine learning and data mining. This book, developed from lectures and tutorials, fulfils two major roles: firstly it provides practitioners with a large toolkit of algorithms, kernels and solutions ready to use for standard pattern discovery problems in fields such as bioinformatics, text analysis, image analysis. Secondly it provides an easy introduction for students and researchers to the growing field of kernel-based pattern analysis, demonstrating with examples how to handcraft an algorithm or a kernel for a new specific application, and covering all the necessary conceptual and mathematical tools to do so.

The Lagrange Multiplier Test and its Applications to Model Specification in Econometrics

Abstract: Many econometric models are susceptible to analysis only by asymptotic techniques and there are three principles, based on asymptotic theory, for the construction of tests of parametric hypotheses. These are: (i) the Wald (W) test which relies on the asymptotic normality of parameter estimators, (ii) the maximum likelihood ratio (LR) procedure and (iii) the Lagrange multiplier (LM) method which tests the effect on the first order conditions for a maximum of the likelihood of imposing the hypothesis. In the econometric literature, most attention seems to have been centred on the first two principles. Familiar " t-tests " usually rely on the W principle for their validity while there have been a number of papers advocating and illustrating the use of the LR procedure. However, all three are equivalent in well-behaved problems in the sense that they give statistics with the same asymptotic distribution when the null hypothesis is true and have the same asymptotic power characteristics. Choice of any one principle must therefore be made by reference to other criteria such as small sample properties or computational convenience. In many situations the W test is attractive for this latter reason because it is constructed from the unrestricted estimates of the parameters and their estimated covariance matrix. The LM test is based on estimation with the hypothesis imposed as parametric restrictions so it seems reasonable that a choice between W or LM be based on the relative ease of estimation under the null and alternative hypotheses. Whenever it is easier to estimate the restricted model, the LM test will generally be more useful. It then provides applied researchers with a simple technique for assessing the adequacy of their particular specification. This paper has two aims. The first is to exposit the various forms of the LM statistic and to collect together some of the relevant research reported in the mathematical statistics literature. The second is to illustrate the construction of LM tests by considering a number of particular econometric specifications as examples. It will be found that in many instances the LM statistic can be computed by a regression using the residuals of the fitted model which, because of its simplicity, is itself estimated by OLS. The paper contains five sections. In Section 2, the LM statistic is outlined and some alternative versions of it are discussed. Section 3 gives the derivation of the statistic for