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Institution

University of Southern Denmark

EducationOdense, Syddanmark, Denmark
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.


Papers
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Journal ArticleDOI
26 Jan 2011-PLOS ONE
TL;DR: There was consistent evidence in age adjusted models that lower childhood SEP was associated with modest reductions in physical capability levels in adulthood, and policies targeting socioeconomic inequalities in childhood may have additional benefits in promoting the maintenance of independence in later life.
Abstract: Background: Grip strength, walking speed, chair rising and standing balance time are objective measures of physical capability that characterise current health and predict survival in older populations. Socioeconomic position (SEP) in childhood may influence the peak level of physical capability achieved in early adulthood, thereby affecting levels in later adulthood. We have undertaken a systematic review with meta-analyses to test the hypothesis that adverse childhood SEP is associated with lower levels of objectively measured physical capability in adulthood. Methods and Findings: Relevant studies published by May 2010 were identified through literature searches using EMBASE and MEDLINE. Unpublished results were obtained from study investigators. Results were provided by all study investigators in a standard format and pooled using random-effects meta-analyses. 19 studies were included in the review. Total sample sizes in meta-analyses ranged from N=17,215 for chair rise time to N=1,061,855 for grip strength. Although heterogeneity was detected, there was consistent evidence in age adjusted models that lower childhood SEP was associated with modest reductions in physical capability levels in adulthood: comparing the lowest with the highest childhood SEP there was a reduction in grip strength of 0.13 standard deviations (95% CI: 0.06, 0.21), a reduction in mean walking speed of 0.07 m/s (0.05, 0.10), an increase in mean chair rise time of 6% (4%, 8%) and an odds ratio of an inability to balance for 5s of 1.26 (1.02, 1.55). Adjustment for the potential mediating factors, adult SEP and body size attenuated associations greatly. However, despite this attenuation, for walking speed and chair rise time, there was still evidence of moderate associations. Conclusions: Policies targeting socioeconomic inequalities in childhood may have additional benefits in promoting the maintenance of independence in later life.

288 citations

Journal ArticleDOI
TL;DR: The results showed that girls are slightly ahead of boys in early communicative gestures, in productive vocabulary, and in combining words, and the difference increased with age, suggesting that the difference is caused by robust factors that do not change between language communities.
Abstract: The present study explored gender differences in emerging language skills in 13,783 European children from 10 non-English language communities. It was based on a synthesis of published data assessed with adapted versions of the MacArthur-Bates Communicative Development Inventories (CDIs) from age 0.08 to 2.06. The results showed that girls are slightly ahead of boys in early communicative gestures, in productive vocabulary, and in combining words. The difference increased with age. Boys were not found to be more variable than girls. Despite extensive variation in language skills between language communities, the difference between girls and boys remained. This suggests that the difference is caused by robust factors that do not change between language communities.

288 citations

Journal ArticleDOI
TL;DR: Multidimensional fractionation as well as desalting, filtration, and concentration prior to mass spectrometry in single or tandem columns is described.
Abstract: Proteome complexity necessitates protein or peptide separation prior to analysis. We previously described a pipet-tip based peptide micropurification system named StageTips (STop and Go Extraction Tips), which consists of a very small disk of membrane-embedded separation material. Here, we extend this approach in several dimensions by stacking disks containing reversed phase (C18) and strong cation exchange (SCX) materials. Multidimensional fractionation as well as desalting, filtration, and concentration prior to mass spectrometry in single or tandem columns is described. C18−SCX−C18 stacked disks significantly improved protein identification by LC−MS/MS for an E. coli protein digest and by MALDI−MS for a 12 standard protein digest. Sequential fractionation based on C18- followed by SCX material was also developed. This multidimensional fractionation approach was expanded to parallel sample preparation by incorporating C18−SCX−StageTips into a 96-well plate (StagePlate). Fractions were collected into oth...

288 citations

Journal ArticleDOI
TL;DR: Two possible pathogenetic mechanisms causing Modic changes are proposed, which could give a more precise and relevant diagnosis to 20-50% of patients with LBP and enable in the development of efficient treatments.

287 citations

Journal ArticleDOI
TL;DR: This work estimated population in 195 locations by single year of age and single calendar year from 1950 to 2017 with standardised and replicable methods and used the cohort-component method of population projection, with inputs of fertility, mortality, population, and migration data.

287 citations


Authors

Showing all 12150 results

NameH-indexPapersCitations
Paul M. Ridker2331242245097
George Davey Smith2242540248373
Matthias Mann221887230213
Eric Boerwinkle1831321170971
Gang Chen1673372149819
Jun Wang1661093141621
Harvey F. Lodish165782101124
Jens J. Holst1601536107858
Rajesh Kumar1494439140830
J. Fraser Stoddart147123996083
Debbie A Lawlor1471114101123
Børge G. Nordestgaard147104795530
Oluf Pedersen135939106974
Rasmus Nielsen13555684898
Torben Jørgensen13588386822
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202382
2022410
20214,042
20203,614
20192,967
20182,603