Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
Papers published on a yearly basis
Papers
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TL;DR: SOAP2 is a significantly improved version of the short oligonucleotide alignment program that both reduces computer memory usage and increases alignment speed at an unprecedented rate and is compatible with both single- and paired-end reads.
Abstract: SOAP2 is a significantly improved version of the short oligonucleotide alignment program that both reduces computer memory usage and increases alignment speed at an unprecedented rate. We used a Burrows Wheeler Transformation (BWT) compression index to substitute the seed strategy for indexing the reference sequence in the main memory. We tested it on the whole human genome and found that this new algorithm reduced memory usage from 14.7 to 5.4 GB and improved alignment speed by 20-30 times. SOAP2 is compatible with both single- and paired-end reads. Additionally, this tool now supports multiple text and compressed file formats. A consensus builder has also been developed for consensus assembly and SNP detection from alignment of short reads on a reference genome.
3,502 citations
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TL;DR: In this article, the authors summarized the basic principles and major achievements of plasmon guiding, and details the current state-of-the-art in subwavelength PLASmonic waveguides, passive and active nanoplasmonic components for the generation, manipulation and detection of radiation, and configurations for the nanofocusing of light.
Abstract: Recent years have seen a rapid expansion of research into nanophotonics based on surface plasmon–polaritons. These electromagnetic waves propagate along metal–dielectric interfaces and can be guided by metallic nanostructures beyond the diffraction limit. This remarkable capability has unique prospects for the design of highly integrated photonic signal-processing systems, nanoresolution optical imaging techniques and sensors. This Review summarizes the basic principles and major achievements of plasmon guiding, and details the current state-of-the-art in subwavelength plasmonic waveguides, passive and active nanoplasmonic components for the generation, manipulation and detection of radiation, and configurations for the nanofocusing of light. Potential future developments and applications of nanophotonic devices and circuits are also discussed, such as in optical signals processing, nanoscale optical devices and near-field microscopy with nanoscale resolution.
3,481 citations
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University of Copenhagen1, Institut national de la recherche agronomique2, Vrije Universiteit Brussel3, South China University of Technology4, Glostrup Hospital5, Aalborg University6, University of Southern Denmark7, Technical University of Denmark8, Wageningen University and Research Centre9, Pierre-and-Marie-Curie University10, French Institute of Health and Medical Research11, University of Helsinki12, Institut de recherche pour le développement13
TL;DR: The authors' classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
Abstract: We are facing a global metabolic health crisis provoked by an obesity epidemic. Here we report the human gut microbial composition in a population sample of 123 non-obese and 169 obese Danish individuals. We find two groups of individuals that differ by the number of gut microbial genes and thus gut bacterial richness. They contain known and previously unknown bacterial species at different proportions; individuals with a low bacterial richness (23% of the population) are characterized by more marked overall adiposity, insulin resistance and dyslipidaemia and a more pronounced inflammatory phenotype when compared with high bacterial richness individuals. The obese individuals among the lower bacterial richness group also gain more weight over time. Only a few bacterial species are sufficient to distinguish between individuals with high and low bacterial richness, and even between lean and obese participants. Our classifications based on variation in the gut microbiome identify subsets of individuals in the general white adult population who may be at increased risk of progressing to adiposity-associated co-morbidities.
3,448 citations
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TL;DR: A general mass spectrometric technology is developed and applied for identification and quantitation of phosphorylation sites as a function of stimulus, time, and subcellular location to provide a missing link in a global, integrative view of cellular regulation.
3,404 citations
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University of Melbourne1, Singapore National Eye Center2, Allergan3, Aarhus University4, National Yang-Ming University5, University of London6, University of Southern Denmark7, Colorado School of Public Health8, Erasmus University Rotterdam9, Yamagata University10, University of Wisconsin-Madison11, L V Prasad Eye Institute12, University of Warwick13, University of Pittsburgh14, University of Turin15, Madras Medical College16, Rutgers University17, The Heart Research Institute18, Johns Hopkins University19, University of Southern California20, University of Sydney21, Capital Medical University22, Kyushu University23, Centers for Disease Control and Prevention24, National University of Singapore25
TL;DR: Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR, and these data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence.
Abstract: OBJECTIVE To examine the global prevalence and major risk factors for diabetic retinopathy (DR) and vision-threatening diabetic retinopathy (VTDR) among people with diabetes. RESEARCH DESIGN AND METHODS A pooled analysis using individual participant data from population-based studies around the world was performed. A systematic literature review was conducted to identify all population-based studies in general populations or individuals with diabetes who had ascertained DR from retinal photographs. Studies provided data for DR end points, including any DR, proliferative DR, diabetic macular edema, and VTDR, and also major systemic risk factors. Pooled prevalence estimates were directly age-standardized to the 2010 World Diabetes Population aged 20–79 years. RESULTS A total of 35 studies (1980–2008) provided data from 22,896 individuals with diabetes. The overall prevalence was 34.6% (95% CI 34.5–34.8) for any DR, 6.96% (6.87–7.04) for proliferative DR, 6.81% (6.74–6.89) for diabetic macular edema, and 10.2% (10.1–10.3) for VTDR. All DR prevalence end points increased with diabetes duration, hemoglobin A 1c , and blood pressure levels and were higher in people with type 1 compared with type 2 diabetes. CONCLUSIONS There are approximately 93 million people with DR, 17 million with proliferative DR, 21 million with diabetic macular edema, and 28 million with VTDR worldwide. Longer diabetes duration and poorer glycemic and blood pressure control are strongly associated with DR. These data highlight the substantial worldwide public health burden of DR and the importance of modifiable risk factors in its occurrence. This study is limited by data pooled from studies at different time points, with different methodologies and population characteristics.
3,282 citations
Authors
Showing all 12150 results
Name | H-index | Papers | Citations |
---|---|---|---|
Paul M. Ridker | 233 | 1242 | 245097 |
George Davey Smith | 224 | 2540 | 248373 |
Matthias Mann | 221 | 887 | 230213 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Gang Chen | 167 | 3372 | 149819 |
Jun Wang | 166 | 1093 | 141621 |
Harvey F. Lodish | 165 | 782 | 101124 |
Jens J. Holst | 160 | 1536 | 107858 |
Rajesh Kumar | 149 | 4439 | 140830 |
J. Fraser Stoddart | 147 | 1239 | 96083 |
Debbie A Lawlor | 147 | 1114 | 101123 |
Børge G. Nordestgaard | 147 | 1047 | 95530 |
Oluf Pedersen | 135 | 939 | 106974 |
Rasmus Nielsen | 135 | 556 | 84898 |
Torben Jørgensen | 135 | 883 | 86822 |