Institution
University of Southern Denmark
Education•Odense, Syddanmark, Denmark•
About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.
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TL;DR: It is reported that through much of the later Neoproterozoic, anoxia remained widespread beneath the mixed layer of the oceans; deeper water masses were sometimes sulfidic but were mainly Fe2+-enriched, marking a return to ocean chemistry not seen for more than one billion years of Earth history.
Abstract: Earth9s surface chemical environment has evolved from an early anoxic condition to the oxic state we have today. Transitional between an earlier Proterozoic world with widespread deep-water anoxia and a Phanerozoic world with large oxygen-utilizing animals, the Neoproterozoic Era [1000 to 542 million years ago (Ma)] plays a key role in this history. The details of Neoproterozoic Earth surface oxygenation, however, remain unclear. We report that through much of the later Neoproterozoic (
644 citations
TL;DR: It is suggested that the chaperonin system may have facilitated the evolution of this fold into a versatile platform for the implementation of numerous enzymatic functions.
643 citations
TL;DR: It is proposed that the MRE11 complex functions at telomeres, possibly by modulating t-loop formation, and is shown that RAD50 protein is present in TRF2 immunocomplexes.
Abstract: Telomeres allow cells to distinguish natural chromosome ends from damaged DNA and protect the ends from degradation and fusion In human cells, telomere protection depends on the TTAGGG repeat binding factor, TRF2 (refs 1-4), which has been proposed to remodel telomeres into large duplex loops (t-loops) Here we show by nanoelectrospray tandem mass spectrometry that RAD50 protein is present in TRF2 immunocomplexes Protein blotting showed that a small fraction of RAD50, MRE11 and the third component of the MRE11 double-strand break (DSB) repair complex, the Nijmegen breakage syndrome protein (NBS1), is associated with TRF2 Indirect immunofluorescence demonstrated the presence of RAD50 and MRE11 at interphase telomeres NBS1 was associated with TRF2 and telomeres in S phase, but not in G1 or G2 Although the MRE11 complex accumulated in irradiation-induced foci (IRIFs) in response to gamma-irradiation, TRF2 did not relocate to IRIFs and irradiation did not affect the association of TRF2 with the MRE11 complex, arguing against a role for TRF2 in DSB repair Instead, we propose that the MRE11 complex functions at telomeres, possibly by modulating t-loop formation
641 citations
TL;DR: It is demonstrated that metal-insulator-metal configurations, with the top metal layer consisting of a periodic arrangement of differently sized nanobricks, can be designed to function as broadband focusing flat mirrors and can be extended to realize the radiation focusing in two dimensions as well as other optical functionalities by suitably controlling the phase distribution of reflected light.
Abstract: We demonstrate that metal–insulator–metal configurations, with the top metal layer consisting of a periodic arrangement of differently sized nanobricks, can be designed to function as broadband foc...
636 citations
Monash University1, University of Amsterdam2, University of Paris3, Bond University4, University of Texas Health Science Center at San Antonio5, University of Ottawa6, American University of Beirut7, Oregon Health & Science University8, University of York9, Ottawa Hospital Research Institute10, University of Southern Denmark11, University of Colorado Denver12, Brigham and Women's Hospital13, Indiana University14, University of Bristol15, University College London16, University of Toronto17
TL;DR: The preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement as discussed by the authors was designed to help systematic reviewers transparently report why the review was done, what the authors did, and what they found.
628 citations
Authors
Showing all 12150 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Paul M. Ridker | 233 | 1242 | 245097 |
| George Davey Smith | 224 | 2540 | 248373 |
| Matthias Mann | 221 | 887 | 230213 |
| Eric Boerwinkle | 183 | 1321 | 170971 |
| Gang Chen | 167 | 3372 | 149819 |
| Jun Wang | 166 | 1093 | 141621 |
| Harvey F. Lodish | 165 | 782 | 101124 |
| Jens J. Holst | 160 | 1536 | 107858 |
| Rajesh Kumar | 149 | 4439 | 140830 |
| J. Fraser Stoddart | 147 | 1239 | 96083 |
| Debbie A Lawlor | 147 | 1114 | 101123 |
| Børge G. Nordestgaard | 147 | 1047 | 95530 |
| Oluf Pedersen | 135 | 939 | 106974 |
| Rasmus Nielsen | 135 | 556 | 84898 |
| Torben Jørgensen | 135 | 883 | 86822 |