University of Southern Denmark

About: University of Southern Denmark is a education organization based out in Odense, Syddanmark, Denmark. It is known for research contribution in the topics: Population & Randomized controlled trial. The organization has 11928 authors who have published 37918 publications receiving 1258559 citations. The organization is also known as: SDU.

The quest for genetic determinants of human longevity: challenges and insights

Abstract: Twin studies show that genetic differences account for about a quarter of the variance in adult human lifespan. Common polymorphisms that have a modest effect on lifespan have been identified in one gene, APOE, providing hope that other genetic determinants can be uncovered. However, although variants with substantial beneficial effects have been proposed to exist and several candidates have been put forward, their effects have yet to be confirmed. Human studies of longevity face numerous theoretical and logistical challenges, as the determinants of lifespan are extraordinarily complex. However, large-scale linkage studies of long-lived families, longitudinal candidate-gene association studies and the development of analytical methods provide the potential for future progress.

What is the lowest possible reheating temperature

Abstract: We study models in which the universe exits reheating at temperatures in the MeV regime. By combining light element abundance measurements with cosmic microwave background and large scale structure data we find a fairly robust lower limit on the reheating temperature of ${T}_{\mathrm{RH}}\ensuremath{\gtrsim}4\mathrm{MeV}$ at 95% C.L. However, if the heavy particle whose decay reheats the universe has a direct decay mode to neutrinos, there are some small islands left in parameter space where a reheating temperature as low as 1 MeV is allowed. The derived lower bound on the reheating temperature also leads to very stringent bounds on models with n large extra dimensions. For $n=2$ the bound on the compactification scale is $M\ensuremath{\gtrsim}2000\mathrm{TeV},$ and for $n=3$ it is 100 TeV. These are currently the strongest available bounds on such models.

Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus

Abstract: Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance. In a genome-wide scan using 85,042 SNPs, we identified an association between SLE and a nonsynonymous substitution (rs10516487, R61H) in the B-cell scaffold protein with ankyrin repeats gene, BANK1. We replicated the association in four independent case-control sets (combined P = 3.7 x 10(-10); OR = 1.38). We analyzed BANK1 cDNA and found two isoforms, one full-length and the other alternatively spliced and lacking exon 2 (Delta2), encoding a protein without a putative IP3R-binding domain. The transcripts were differentially expressed depending on a branch point-site SNP, rs17266594, in strong linkage disequilibrium (LD) with rs10516487. A third associated variant was found in the ankyrin domain (rs3733197, A383T). Our findings implicate BANK1 as a susceptibility gene for SLE, with variants affecting regulatory sites and key functional domains. The disease-associated variants could contribute to sustained B cell-receptor signaling and B-cell hyperactivity characteristic of this disease.