Institution
University of St Andrews
Education•St Andrews, Fife, United Kingdom•
About: University of St Andrews is a education organization based out in St Andrews, Fife, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 16260 authors who have published 43364 publications receiving 1636072 citations. The organization is also known as: St Andrews University & University of St. Andrews.
Topics: Population, Laser, Planet, Galaxy, Stars
Papers published on a yearly basis
Papers
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TL;DR: It is found that differentially expressed mRNAs correlate significantly better with their protein product than non-differentially expressed MNCs, providing optimism for the usefulness of inferences from mRNA expression in general.
Abstract: Differential mRNA expression studies implicitly assume that changes in mRNA expression have biological meaning, most likely mediated by corresponding changes in protein levels. Yet studies into mRNA-protein correspondence have shown notoriously poor correlation between mRNA and protein expression levels, creating concern for inferences from only mRNA expression data. However, none of these studies have examined in particular differentially expressed mRNA. Here, we examined this question in an ovarian cancer xenograft model. We measured protein and mRNA expression for twenty-nine genes in four drug-treatment conditions and in untreated controls. We identified mRNAs differentially expressed between drug-treated xenografts and controls, then analysed mRNA-protein expression correlation across a five-point time-course within each of the four experimental conditions. We evaluated correlations between mRNAs and their protein products for mRNAs differentially expressed within an experimental condition compared to those that are not. We found that differentially expressed mRNAs correlate significantly better with their protein product than non-differentially expressed mRNAs. This result increases confidence for the use of differential mRNA expression for biological discovery in this system, as well as providing optimism for the usefulness of inferences from mRNA expression in general.
401 citations
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TL;DR: A region of the right posterior superior temporal sulcus is described that is sensitive not to articulated body motion per se, but to the relationship between the observed motion and the structure of the surrounding environment, and it is hypothesized that this region is involved in the representation of observed intentional actions.
400 citations
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Centre national de la recherche scientifique1, IFREMER2, ETH Zurich3, Cardiff University4, University of Bern5, Université Paris-Saclay6, University of Bordeaux7, Federal Fluminense University8, Leibniz Institute for Baltic Sea Research9, University of St Andrews10, University of New Hampshire11, Oregon State University12, École pratique des hautes études13, Royal Holloway, University of London14, University of Nantes15, Hofstra University16, Lamont–Doherty Earth Observatory17, Uppsala University18, Woods Hole Oceanographic Institution19, University of Edinburgh20, Geological Survey of Denmark and Greenland21, Instituto Geológico y Minero de España22, University of Connecticut23, Georgia Institute of Technology24, University of Colorado Boulder25, University of the Algarve26, British Antarctic Survey27, VU University Amsterdam28, University of Bremen29, Max Planck Society30, Thermo Fisher Scientific31, University of Cambridge32, University of Paris33, University College London34, Ghent University35, Aix-Marseille University36, Autonomous University of Barcelona37, University of California, Santa Barbara38, Utrecht University39
TL;DR: This is the first set of consistently dated marine sediment cores enabling paleoclimate scientists to evaluate leads/lags between circulation and climate changes over vast regions of the Atlantic Ocean.
Abstract: Rapid changes in ocean circulation and climate have been observed in marine-sediment and ice cores over the last glacial period and deglaciation, highlighting the non-linear character of the climate system and underlining the possibility of rapid climate shifts in response to anthropogenic greenhouse gas forcing. To date, these rapid changes in climate and ocean circulation are still not fully explained. One obstacle hindering progress in our understanding of the interactions between past ocean circulation and climate changes is the difficulty of accurately dating marine cores. Here, we present a set of 92 marine sediment cores from the Atlantic Ocean for which we have established age-depth models that are consistent with the Greenland GICC05 ice core chronology, and computed the associated dating uncertainties, using a new deposition modeling technique. This is the first set of consistently dated marine sediment cores enabling paleoclimate scientists to evaluate leads/lags between circulation and climate changes over vast regions of the Atlantic Ocean. Moreover, this data set is of direct use in paleoclimate modeling studies.
399 citations
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Chinese Academy of Sciences1, Institute of Cosmology and Gravitation, University of Portsmouth2, University of Chicago3, Leiden University4, Simon Fraser University5, University of Cambridge6, Apache Corporation7, Leibniz Institute for Astrophysics Potsdam8, Autonomous University of Madrid9, University of Barcelona10, University of Córdoba (Spain)11, Harvard University12, Spanish National Research Council13, University of La Laguna14, Korea Astronomy and Space Science Institute15, Aix-Marseille University16, Ohio State University17, Sejong University18, Max Planck Society19, New York University20, University of St Andrews21, Brookhaven National Laboratory22
TL;DR: In this article, the authors investigated whether these tensions can be interpreted as evidence for a non-constant dynamical dark energy and found that the tensions are relieved by an evolving dark energy model preferred at a 3.5σ significance level based on the improvement in the fit alone.
Abstract: A flat Friedmann–Robertson–Walker universe dominated by a cosmological constant (Λ) and cold dark matter (CDM) has been the working model preferred by cosmologists since the discovery of cosmic acceleration1,2. However, tensions of various degrees of significance are known to be present among existing datasets within the ΛCDM framework3,4,5,6,7,8,9,10,11. In particular, the Lyman-α forest measurement of the baryon acoustic oscillations (BAO) by the Baryon Oscillation Spectroscopic Survey3 prefers a smaller value of the matter density fraction Ω M than that preferred by cosmic microwave background (CMB). Also, the recently measured value of the Hubble constant, H 0 = 73.24 ± 1.74 km s−1 Mpc−1 (ref. 12), is 3.4σ higher than the 66.93 ± 0.62 km s−1 Mpc−1 inferred from the Planck CMB data7. In this work, we investigate whether these tensions can be interpreted as evidence for a non-constant dynamical dark energy. Using the Kullback–Leibler divergence13 to quantify the tension between datasets, we find that the tensions are relieved by an evolving dark energy, with the dynamical dark energy model preferred at a 3.5σ significance level based on the improvement in the fit alone. While, at present, the Bayesian evidence for the dynamical dark energy is insufficient to favour it over ΛCDM, we show that, if the current best-fit dark energy happened to be the true model, it would be decisively detected by the upcoming Dark Energy Spectroscopic Instrument survey14.
398 citations
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TL;DR: A phylogenetic analysis of chloroplast DNA variation in the purple saxifrage indicates that this plant first occurred in the Arctic in western Beringia before it migrated east and west to achieve a circumpolar distribution.
Abstract: The arctic flora is thought to have originated during the late Tertiary, approximately 3 million years ago. Plant migration routes during colonization of the Arctic are currently unknown, and uncertainty remains over where arctic plants survived Pleistocene glaciations. A phylogenetic analysis of chloroplast DNA variation in the purple saxifrage (Saxifraga oppositifolia) indicates that this plant first occurred in the Arctic in western Beringia before it migrated east and west to achieve a circumpolar distribution. The geographical distribution of chloroplast DNA variation in the species supports the hypothesis that, during Pleistocene glaciations, some plant refugia were located in the Arctic as well as at more southern latitudes.
397 citations
Authors
Showing all 16531 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Paul M. Thompson | 183 | 2271 | 146736 |
Ian J. Deary | 166 | 1795 | 114161 |
Dongyuan Zhao | 160 | 872 | 106451 |
Mark J. Smyth | 153 | 713 | 88783 |
Harry Campbell | 150 | 897 | 115457 |
William J. Sutherland | 148 | 966 | 94423 |
Thomas J. Smith | 140 | 1775 | 113919 |
John A. Peacock | 140 | 565 | 125416 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
David A. Jackson | 136 | 1095 | 68352 |
Ian Ford | 134 | 678 | 85769 |
Timothy J. Mitchison | 133 | 404 | 66418 |
Will J. Percival | 129 | 473 | 87752 |
David P. Lane | 129 | 568 | 90787 |