Institution
University of St Andrews
Education•St Andrews, Fife, United Kingdom•
About: University of St Andrews is a education organization based out in St Andrews, Fife, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 16260 authors who have published 43364 publications receiving 1636072 citations. The organization is also known as: St Andrews University & University of St. Andrews.
Topics: Population, Laser, Stars, Catalysis, Galaxy
Papers published on a yearly basis
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University of Pennsylvania1, Children's Hospital of Philadelphia2, Icahn School of Medicine at Mount Sinai3, University of California, Los Angeles4, University of Utah5, National Institutes of Health6, State University of New York Upstate Medical University7, Goethe University Frankfurt8, University of Zurich9, University of Basel10, Aarhus University Hospital11, Washington University in St. Louis12, University of Würzburg13, University of Göttingen14, Radboud University Nijmegen Medical Centre15, Harvard University16, Ghent University17, Heidelberg University18, National University of Singapore19, University of Duisburg-Essen20, VU University Amsterdam21, New York University22, University of Southampton23, University of Trier24, Saarland University25, Semel Institute for Neuroscience and Human Behavior26, University of St Andrews27, Trinity College, Dublin28, Cardiff University29
TL;DR: A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ∼10% of the cases, and rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts were identified.
Abstract: Attention deficit hyperactivity disorder (ADHD) is a common, heritable neuropsychiatric disorder of unknown etiology. We performed a whole-genome copy number variation (CNV) study on 1,013 cases with ADHD and 4,105 healthy children of European ancestry using 550,000 SNPs. We evaluated statistically significant findings in multiple independent cohorts, with a total of 2,493 cases with ADHD and 9,222 controls of European ancestry, using matched platforms. CNVs affecting metabotropic glutamate receptor genes were enriched across all cohorts (P = 2.1 × 10−9). We saw GRM5 (encoding glutamate receptor, metabotropic 5) deletions in ten cases and one control (P = 1.36 × 10−6). We saw GRM7 deletions in six cases, and we saw GRM8 deletions in eight cases and no controls. GRM1 was duplicated in eight cases. We experimentally validated the observed variants using quantitative RT-PCR. A gene network analysis showed that genes interacting with the genes in the GRM family are enriched for CNVs in ~10% of the cases (P = 4.38 × 10−10) after correction for occurrence in the controls. We identified rare recurrent CNVs affecting glutamatergic neurotransmission genes that were overrepresented in multiple ADHD cohorts.
340 citations
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TL;DR: The p300 protein serves as a rate-limiting transcriptional cointegrator of diverse transcription factors either to activate or to repress transcription through modular subdomains and may serve an important integration point during metabolism and cellular differentiation.
339 citations
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TL;DR: In this article, the minority charge carrying capacity of the homopolymers is probed: it is shown that the quinoxaline derivative has hole blocking properties superior to those of the oxadiazole polymer and is a good candidate for use in optimised devices.
Abstract: Improved syntheses and polymerisations are reported of monomers bearing electron transporting substituents based on 2,5-diphenyloxadiazole and 2,3-diphenylquinoxaline attached directly to a vinyl group. By copolymerisation and by use of mixtures of homopolymers, these materials have been incorporated into light emitting polymer devices in which hole conduction properties are provided by 4-vinyltriphenylamine groups. High luminescence efficiency is achieved by use of a fluorescent additive. The resulting devices show narrow emission bands and high brightnesses, except in the case of those based on a diphenyloxadiazole–triphenylamine polymer blend. Thermal analysis data are equivocal but we present evidence that in this system, but not the quinoxaline blend, phase separation occurs. The minority charge carrying capacity of the homopolymers is probed: it is shown that the quinoxaline derivative has hole blocking properties superior to those of the oxadiazole polymer and is
a good candidate for use in optimised devices.
339 citations
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TL;DR: CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity in tumor cell lines that express CD70 and interact with CD27, which is constitutively expressed on NK cells.
Abstract: Natural killer (NK) cells may modulate the development of adaptive immune responses, but until now there has been little evidence to support this hypothesis. We investigated the primary and secondary immunity elicited by various tumor cell lines that express CD70 and interact with CD70 ligand (CD27), which is constitutively expressed on NK cells. CD70 expression enhanced primary tumor rejection in vivo as well as T cell immunity against secondary tumor challenge. Primary rejection of major histocompatibility complex (MHC) class I-deficient RMA-S.CD70 tumor cells was mediated by NK cells and perforin- and interferon-gamma-dependent mechanisms. This NK cell-mediated process also efficiently evoked the subsequent development of tumor-specific cytotoxic and T helper type 1 responses to the parental, MHC class I-sufficient, RMA tumor cells. Thus CD27-CD70 interactions provide a key link between innate NK cell responses and adaptive T cell immunity.
339 citations
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TL;DR: It is shown that free-ranging putty-nosed monkeys combine two vocalizations into different call sequences that are linked to specific external events, such as the presence of a predator and the imminent movement of the group.
Abstract: Putty-nosed monkeys rely on two basic calling sounds to construct a message of utmost urgency.
339 citations
Authors
Showing all 16531 results
Name | H-index | Papers | Citations |
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Yi Chen | 217 | 4342 | 293080 |
Paul M. Thompson | 183 | 2271 | 146736 |
Ian J. Deary | 166 | 1795 | 114161 |
Dongyuan Zhao | 160 | 872 | 106451 |
Mark J. Smyth | 153 | 713 | 88783 |
Harry Campbell | 150 | 897 | 115457 |
William J. Sutherland | 148 | 966 | 94423 |
Thomas J. Smith | 140 | 1775 | 113919 |
John A. Peacock | 140 | 565 | 125416 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
David A. Jackson | 136 | 1095 | 68352 |
Ian Ford | 134 | 678 | 85769 |
Timothy J. Mitchison | 133 | 404 | 66418 |
Will J. Percival | 129 | 473 | 87752 |
David P. Lane | 129 | 568 | 90787 |