Institution
University of St Andrews
Education•St Andrews, Fife, United Kingdom•
About: University of St Andrews is a education organization based out in St Andrews, Fife, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 16260 authors who have published 43364 publications receiving 1636072 citations. The organization is also known as: St Andrews University & University of St. Andrews.
Topics: Population, Laser, Planet, Galaxy, Stars
Papers published on a yearly basis
Papers
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TL;DR: In this paper, a realistic theoretical model of steady Langmuir circulations is constructed, where the wind direction is generated by the Stokes drift of the gravity-wave field acting upon spanwise vorticity deriving from the wind-driven current.
Abstract: A realistic theoretical model of steady Langmuir circulations is constructed. Vorticity in the wind direction is generated by the Stokes drift of the gravity-wave field acting upon spanwise vorticity deriving from the wind-driven current. We believe that the steady Langmuir circulations represent a balance between this generating mechanism and turbulent dissipation.Nonlinear equations governing the motion are derived under fairly general conditions. Analytical and numerical solutions are sought for the case of a directional wave spectrum consisting of a single pair of gravity waves propagating at equal and opposite angles to the wind direction. Also, a statistical analysis, based on linearized equations, is developed for more general directional wave spectra. This yields an estimate of the average spacing of windrows associated with Langmuir circulations. The latter analysis is applied to a particular example with simple properties, and produces an expected windrow spacing of rather more than twice the length of the dominant gravity waves.The relevance of our model is assessed with reference to known observational features, and the evidence supporting its applicability is promising.
666 citations
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TL;DR: It is shown that p53 is modified by the small ubiquitin‐like protein SUMO‐1 at a single site, K386, in the C‐terminus of the protein, and may represent a novel target for the development of therapeutically useful modulators of the p53 response.
Abstract: The p53 tumour suppressor protein is regulated by ubiquitin-mediated proteasomal degradation. In normal cells p53 is constitutively ubiquitylated by the Mdm2 ubiquitin ligase. When the p53 response is activated by stress signals p53 levels rise due to inhibition of this degradative pathway. Here we show that p53 is modified by the small ubiquitin-like protein SUMO-1 at a single site, K386, in the C-terminus of the protein. Modification in vitro requires only SUMO-1, the SUMO-1 activating enzyme and ubc9. SUMO-1 and ubiquitin modification do not compete for the same lysine acceptor sites in p53. Overexpression of SUMO-1 activates the transcriptional activity of wild-type p53, but not K386R p53 where the SUMO-1 acceptor site has been mutated. The SUMO-1 modification pathway therefore acts as a potential regulator of the p53 response and may represent a novel target for the development of therapeutically useful modulators of the p53 response.
666 citations
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TL;DR: The top 10 fluorine containing pharmaceuticals (by US Sales in 2008) are highlighted in this article, where the structures and modes of action of these important drugs compounds are reviewed and representative synthetic routes are highlighted.
663 citations
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TL;DR: In this article, the authors show that general relativity provides the theoretical tools for designing devices made of metamaterials, such as perfect invisibility devices, perfect lenses, the optical Aharonov-Bohm effect and electromagnetic analogues of the event horizon.
Abstract: In electrical engineering metamaterials have been developed that offer unprecedented control over electromagnetic fields. Here, we show that general relativity provides the theoretical tools for designing devices made of such versatile materials. Given a desired device function, the theory describes the electromagnetic properties that turn this function into fact. We consider media that facilitate space-time transformations and include negative refraction. Our theory unifies the concepts operating behind the scenes of perfect invisibility devices, perfect lenses, the optical Aharonov–Bohm effect and electromagnetic analogues of the event horizon, and may lead to further applications.
660 citations
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04 May 2008TL;DR: This work used ultrashort pulses in microstructured optical fibers to demonstrate the formation of an artificial event horizon in optics and observed a classical optical effect: the blue-shifting of light at a white-hole horizon.
Abstract: We present a realistic scheme for an artificial event horizon in optics with ultrashort pulses in microstructured fibers that can probe the quantum effects of horizons, particularly Hawking radiation. We also show experimental progress.
658 citations
Authors
Showing all 16531 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Paul M. Thompson | 183 | 2271 | 146736 |
Ian J. Deary | 166 | 1795 | 114161 |
Dongyuan Zhao | 160 | 872 | 106451 |
Mark J. Smyth | 153 | 713 | 88783 |
Harry Campbell | 150 | 897 | 115457 |
William J. Sutherland | 148 | 966 | 94423 |
Thomas J. Smith | 140 | 1775 | 113919 |
John A. Peacock | 140 | 565 | 125416 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
David A. Jackson | 136 | 1095 | 68352 |
Ian Ford | 134 | 678 | 85769 |
Timothy J. Mitchison | 133 | 404 | 66418 |
Will J. Percival | 129 | 473 | 87752 |
David P. Lane | 129 | 568 | 90787 |