University of St Andrews

About: University of St Andrews is a education organization based out in St Andrews, Fife, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 16260 authors who have published 43364 publications receiving 1636072 citations. The organization is also known as: St Andrews University & University of St. Andrews.

A rational model for Langmuir circulations

Abstract: A realistic theoretical model of steady Langmuir circulations is constructed. Vorticity in the wind direction is generated by the Stokes drift of the gravity-wave field acting upon spanwise vorticity deriving from the wind-driven current. We believe that the steady Langmuir circulations represent a balance between this generating mechanism and turbulent dissipation.Nonlinear equations governing the motion are derived under fairly general conditions. Analytical and numerical solutions are sought for the case of a directional wave spectrum consisting of a single pair of gravity waves propagating at equal and opposite angles to the wind direction. Also, a statistical analysis, based on linearized equations, is developed for more general directional wave spectra. This yields an estimate of the average spacing of windrows associated with Langmuir circulations. The latter analysis is applied to a particular example with simple properties, and produces an expected windrow spacing of rather more than twice the length of the dominant gravity waves.The relevance of our model is assessed with reference to known observational features, and the evidence supporting its applicability is promising.

SUMO-1 modification activates the transcriptional response of p53

Abstract: The p53 tumour suppressor protein is regulated by ubiquitin-mediated proteasomal degradation. In normal cells p53 is constitutively ubiquitylated by the Mdm2 ubiquitin ligase. When the p53 response is activated by stress signals p53 levels rise due to inhibition of this degradative pathway. Here we show that p53 is modified by the small ubiquitin-like protein SUMO-1 at a single site, K386, in the C-terminus of the protein. Modification in vitro requires only SUMO-1, the SUMO-1 activating enzyme and ubc9. SUMO-1 and ubiquitin modification do not compete for the same lysine acceptor sites in p53. Overexpression of SUMO-1 activates the transcriptional activity of wild-type p53, but not K386R p53 where the SUMO-1 acceptor site has been mutated. The SUMO-1 modification pathway therefore acts as a potential regulator of the p53 response and may represent a novel target for the development of therapeutically useful modulators of the p53 response.

General relativity in electrical engineering

Abstract: In electrical engineering metamaterials have been developed that offer unprecedented control over electromagnetic fields. Here, we show that general relativity provides the theoretical tools for designing devices made of such versatile materials. Given a desired device function, the theory describes the electromagnetic properties that turn this function into fact. We consider media that facilitate space-time transformations and include negative refraction. Our theory unifies the concepts operating behind the scenes of perfect invisibility devices, perfect lenses, the optical Aharonov–Bohm effect and electromagnetic analogues of the event horizon, and may lead to further applications.

Fiber-optical analogue of the event horizon

Abstract: We present a realistic scheme for an artificial event horizon in optics with ultrashort pulses in microstructured fibers that can probe the quantum effects of horizons, particularly Hawking radiation. We also show experimental progress.