Institution
University of St Andrews
Education•St Andrews, Fife, United Kingdom•
About: University of St Andrews is a education organization based out in St Andrews, Fife, United Kingdom. It is known for research contribution in the topics: Population & Laser. The organization has 16260 authors who have published 43364 publications receiving 1636072 citations. The organization is also known as: St Andrews University & University of St. Andrews.
Topics: Population, Laser, Planet, Galaxy, Stars
Papers published on a yearly basis
Papers
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TL;DR: This model allows us to estimate the number of NGFs present in the ovary at any given age, suggests that 81% of the variance in NGF populations is due to age alone, and shows for the first time, to the knowledge, that the rate of N GF recruitment increases from birth to age 14 years then declines with age until menopause.
Abstract: The human ovary contains a fixed number of non-growing follicles (NGFs) established before birth that decline with increasing age culminating in the menopause at 50-51 years. The objective of this study is to model the age-related population of NGFs in the human ovary from conception to menopause. Data were taken from eight separate quantitative histological studies (n = 325) in which NGF populations at known ages from seven weeks post conception to 51 years (median 32 years) were calculated. The data set was fitted to 20 peak function models, with the results ranked by obtained r2 correlation coefficient. The highest ranked model was chosen. Our model matches the log-adjusted NGF population from conception to menopause to a five-parameter asymmetric double Gaussian cumulative (ADC) curve (r2 = 0.81). When restricted to ages up to 25 years, the ADC curve has r2 = 0.95. We estimate that for 95% of women by the age of 30 years only 12% of their maximum pre-birth NGF population is present and by the age of 40 years only 3% remains. Furthermore, we found that the rate of NGF recruitment towards maturation for most women increases from birth until approximately age 14 years then decreases towards the menopause. To our knowledge, this is the first model of ovarian reserve from conception to menopause. This model allows us to estimate the number of NGFs present in the ovary at any given age, suggests that 81% of the variance in NGF populations is due to age alone, and shows for the first time, to our knowledge, that the rate of NGF recruitment increases from birth to age 14 years then declines with age until menopause. An increased understanding of the dynamics of human ovarian reserve will provide a more scientific basis for fertility counselling for both healthy women and those who have survived gonadotoxic cancer treatments.
571 citations
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TL;DR: Although the precise mechanism of action of VNS is still unknown, the search for the mechanism has the potential to lend new insight into the neuropathology of depression, a review of the pre-clinical and clinical literature relating to VNS concludes.
568 citations
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TL;DR: The age relations for assembly of Gondwana and Pangea indicate that the timing of collisional orogenesis between amalgamating continental bodies was synchronous with subduction initiation and contractional orogens within accretionary orogens located along the margins of these supercontinents as mentioned in this paper.
567 citations
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TL;DR: The SuperCOSMOS Sky Survey (SSSSS) as mentioned in this paper is a wide-scale survey of images collected by the International Journal of Astronomy and Geophysics.
Abstract: In this, the first in a series of three papers concerning the SuperCOSMOS Sky Survey (SSS), we give an introduction and user guide to the survey programme. We briefly describe other wide-field surveys and compare with our own. We give examples of the data, and make a comparison of the accuracies of the various image parameters available with those from the other surveys providing similar data; we show that the SSS database and interface offer advantages over these surveys. Some science applications of the data are also described and some limitations discussed. The series of three papers constitutes a comprehensive description and user guide for the SSS.
566 citations
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TL;DR: Based on the anatomical connections of these areas, and the Hebbian learning rule, a simple but powerful account of how the monkey brain can learn to understand the actions of others by associating them with self-produced actions, at the also discriminating its own actions from those of others is proposed.
565 citations
Authors
Showing all 16531 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Paul M. Thompson | 183 | 2271 | 146736 |
Ian J. Deary | 166 | 1795 | 114161 |
Dongyuan Zhao | 160 | 872 | 106451 |
Mark J. Smyth | 153 | 713 | 88783 |
Harry Campbell | 150 | 897 | 115457 |
William J. Sutherland | 148 | 966 | 94423 |
Thomas J. Smith | 140 | 1775 | 113919 |
John A. Peacock | 140 | 565 | 125416 |
Jean-Marie Tarascon | 136 | 853 | 137673 |
David A. Jackson | 136 | 1095 | 68352 |
Ian Ford | 134 | 678 | 85769 |
Timothy J. Mitchison | 133 | 404 | 66418 |
Will J. Percival | 129 | 473 | 87752 |
David P. Lane | 129 | 568 | 90787 |