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Institution

University of Stirling

EducationStirling, Stirling, United Kingdom
About: University of Stirling is a education organization based out in Stirling, Stirling, United Kingdom. It is known for research contribution in the topics: Population & Polyunsaturated fatty acid. The organization has 7722 authors who have published 20549 publications receiving 732940 citations. The organization is also known as: Stirling University.


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Journal ArticleDOI
TL;DR: Lipid-lowering therapy is effective in reducing cardiovascular mortality and morbidity in people with PAD and it may also improve local symptoms.
Abstract: Background Lipid-lowering therapy is recommended for secondary prevention in people with coronary artery disease. It may also reduce cardiovascular events and/or local disease progression in people with lower limb peripheral arterial disease (PAD). Objectives To assess the effects of lipid-lowering therapy on all-cause mortality, cardiovascular events and local disease progression in patients with PAD of the lower limb. Search methods The authors searched The Cochrane Peripheral Vascular Diseases Group's Specialised Register (last searched February 2007) and the Cochrane Central Register of Controlled Trials (CENTRAL) (last searched Issue 2, 2007) for publications describing randomised controlled trials of lipid-lowering therapy in peripheral arterial disease of the lower limb. Selection criteria Randomised controlled trials of lipid-lowering therapy in patients with PAD of the lower limb. Data collection and analysis Three authors independently assessed trial quality and extracted data. Main results Eighteen trials were included, involving a total of 10,049 participants. Trials differed considerably in their inclusion criteria, outcomes measured, and type of lipid-lowering therapy used. Only one trial (PQRST) reported a detrimental effect of active treatment on blood lipid/lipoprotein levels. The pooled results from all eligible trials indicated that lipid-lowering therapy had no statistically significant effect on overall mortality (Odds Ratio (OR) 0.86; 95% Confidence Interval (CI) 0.49 to 1.50) or on total cardiovascular events (OR 0.8; 95% CI 0.59 to 1.09). However, subgroup analysis which excluded PQRST showed that lipid-lowering therapy significantly reduced the risk of total cardiovascular events (OR 0.74; CI 0.55 to 0.98). This was primarily due to a positive effect on total coronary events (OR 0.76; 95% CI 0.67 to 0.87). Greatest evidence of effectiveness came from the use of simvastatin in people with a blood cholesterol ≥ 3.5 mmol/litre (HPS). Pooling of the results from several small trials on a range of different lipid-lowering agents indicated an improvement in total walking distance (Mean Difference (MD) 152 m; 95% CI 32.11 to 271.88) and pain-free walking distance (WMD 89.76 m; 95% CI 30.05 to 149.47) but no significant impact on ankle brachial index (WMD 0.04; 95% CI -0.01 to 0.09). Authors' conclusions Lipid-lowering therapy is effective in reducing cardiovascular mortality and morbidity in people with PAD. It may also improve local symptoms. Until further evidence on the relative effectiveness of different lipid-lowering agents is available, use of a statin in people with PAD and a blood cholesterol level ≥ 3.5 mmol/litre is most indicated.

176 citations

Journal ArticleDOI
TL;DR: With the dose, duration, and preparation of LCPUFA used, efficacy was not demonstrated, although an advantage in later neurodevelopment cannot be excluded by global tests of development up to 18 months, particularly in infants below 30 weeks' gestation.
Abstract: Objective. We tested the hypothesis that balanced addition of long-chain polyunsaturated fatty acid (LCPUFA) to preterm formula during the first weeks of life would confer long-term neurodevelopmental advantage in a double-blind, randomized, controlled trial of preterm formula with and without preformed LCPUFA. Methods. The participants were 195 formula-fed preterm infants (birth weight <1750 g, gestation <37 weeks) from 2 UK neonatal units and 88 breast milk-fed infants. Main outcome measures were Bayley Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) at 18 months and Knobloch, Passamanick and Sherrard's Developmental Screening Inventory at 9 months' corrected age. Safety outcome measures were anthropometry at 9 and 18 months, tolerance, infection, necrotizing enterocolitis, and death. Results. There were no significant differences in developmental scores between randomized groups, although infants who were fed LCPUFA-supplemented formula showed a nonsignificant 2.6-point (0.25 standard deviation) advantage in MDI and PDI at 18 months, with a greater (nonsignificant) advantage (MDI: 4.5 points; PDI: 5.8 points) in infants below 30 weeks' gestation. LCPUFA-supplemented infants were shorter than control infants at 18 months (difference in length standard deviation score: 0.44; 95% confidence interval: 0.08-0.8). No other significant short- or long-term differences in safety outcomes were observed. Breastfed infants had significantly higher developmental scores at 9 and 18 months than both formula groups and were significantly heavier and longer at 18 months than LCPUFA-supplemented but not control infants. Conclusions. With the dose, duration, and preparation of LCPUFA used, efficacy was not demonstrated, although an advantage in later neurodevelopment cannot be excluded by global tests of development up to 18 months, particularly in infants below 30 weeks' gestation. The surprising effect of LCPUFA-supplemented formula on growth 18 months beyond the intervention period needs to be confirmed in other studies using similar supplementation strategies. Additional follow-up of this cohort is critical at an age when more specific tests of cognitive function are possible.

176 citations

Journal ArticleDOI
TL;DR: In this paper, the authors argue that the professions have come to dominate our world, and that their knowledge and decisions influence all facets of modern life, as Abbott (1988) expresses it: "They heal our bodies, measure our profit, and decide our decisions."
Abstract: Professionals’ knowledge and decisions influence all facets of modern life. As Abbott (1988) expresses it, the professions have come to ‘dominate our world. They heal our bodies, measure our profit...

176 citations

Journal ArticleDOI
TL;DR: This meta-analysis of primary research data reporting the prevalence of gestational diabetes mellitus in the general pregnant population of developed countries in Europe shows prevalence of GDM that is at the upper end of previous estimates in Europe.

175 citations

Journal ArticleDOI
TL;DR: This work shows empirically that facial identity information is conveyed largely via mechanisms tuned to horizontal visual structure, and shows that such structure affords computational advantages for face detection and decoding, including robustness to normal environmental image degradation.
Abstract: The structure of the human face allows it to signal a wide range of useful information about a person's gender, identity, mood, etc. We show empirically that facial identity information is conveyed largely via mechanisms tuned to horizontal visual structure. Specifically observers perform substantially better at identifying faces that have been filtered to contain just horizontal information compared to any other orientation band. We then show, computationally, that horizontal structures within faces have an unusual tendency to fall into vertically co-aligned clusters compared with images of natural scenes. We call these clusters "bar codes" and propose that they have important computational properties. We propose that it is this property makes faces "special" visual stimuli because they are able to transmit information as reliable spatial sequence: a highly constrained one-dimensional code. We show that such structure affords computational advantages for face detection and decoding, including robustness to normal environmental image degradation, but makes faces vulnerable to certain classes of transformation that change the sequence of bars such as spatial inversion or contrast-polarity reversal.

175 citations


Authors

Showing all 7824 results

NameH-indexPapersCitations
Paul M. Thompson1832271146736
Alan D. Baddeley13746789497
Wolf Singer12458072591
John J. McGrath120791124804
Richard J. Simpson11385059378
David I. Perrett11035045878
Simon P. Driver10945546299
David J. Williams107206062440
Linqing Wen10741270794
John A. Raven10655544382
David Coward10340067118
Stuart J. H. Biddle10248441251
Malcolm T. McCulloch10037136914
Andrew P. Dobson9832244211
Lister Staveley-Smith9559936924
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202357
2022175
20211,041
20201,054
2019916
2018903