University of Stirling

About: University of Stirling is a education organization based out in Stirling, Stirling, United Kingdom. It is known for research contribution in the topics: Population & Polyunsaturated fatty acid. The organization has 7722 authors who have published 20549 publications receiving 732940 citations. The organization is also known as: Stirling University.

‘Knowledge Must Be Contextual’: Some possible implications of complexity and dynamic systems theories for educational research

Abstract: It is now widely accepted that qualitative and quantitative research traditions, rather than being seen as opposed to or in competition with each other ( ; ) should be used, where appropriate, in some kind of combination (; ). How this combining is to be understood ontologically, and therefore epistemologically, however, is not always clear. Rather than endlessly discussing the relationship between different approaches, this paper explores some of the assumptions of the ontologies that underpin such apparent differences, arguing that approaches which declare themselves to be distinct theoretically are often surprisingly similar methodologically. It is argued that dominant ontologies and epistemologies struggle with the conceptualisation and representation of particularity, difference, process, interactions through time, multiple and de‐centred forms of causation, and dynamic structure. Complexity/dynamic systems theory is then introduced and examined for its potential to offer the basis of a different kin...

Effects of diets containing linseed oil on fatty acid desaturation and oxidation in hepatocytes and intestinal enterocytes in Atlantic salmon (Salmo salar)

Abstract: We hypothesized that replacing fish oil with 18:3n-3-rich linseed oil may enable salmon to maintain the levels of tissue n-3HUFA levels through a combination of increased desaturation activity and increased substrate fatty acid provision. To this end we investigated desaturation/elongation of [1-14C18:3n-3 in hepatocytes and intestinal enterocytes, and determined the extent to which 18:3n-3 was oxidized and desaturated by measuring both simultaneously in a combined assay. Salmon smolts were stocked randomly into five seawater pens and fed for 40 weeks on diets in which the fish oil was replaced in a graded manner by linseed oil. At the end of the trial, fatty acyl desaturation/elongation and oxidation activities were determined in isolated hepatocytes and intestinal enterocytes using [1-14C]18:3n-3 as substrate, and samples of liver and intestinal tissue were collected for analysis of lipid and fatty acid composition. The results showed that, despite increased desaturation of [1-14C]18:3n-3 in hepatocytes, provision of dietary 18:3n-3 did not prevent the decrease in tissue n-3HUFA in fish fed linseed oil. Intestinal enterocytes were a site of significant fatty acid desaturation but, in contrast to hepatocytes, the activity was not increased by feeding linseed oil and was generally lower in fish fed linseed oil compared to fish fed only fish oil. In contrast, oxidation of [1-14C]18:3n-3 in enterocytes was generally increased in fish fed linseed oil compared to fish fed the diet containing only fish oil. However, oxidation of [1-14C]18:3n-3 in hepatocytes was 4- to 8-fold lower than in enterocytes and was not affected by diet. Furthermore, oxidation of [1-14C]18:3n-3 in enterocytes exceeded desaturation irrespective of dietary treatment, whereas similar amounts of [1-14C]18:3n-3 were desaturated and oxidized in hepatocytes from fish fed only fish oil and desaturation exceeded oxidation by 3-fold in fish fed the diet containing 100% linseed oil. The molecular mechanisms underpinning these results were discussed.

Analysis of aggregated parasite distributions: A comparison of methods

Abstract: 1. Empirically, parasite distributions are often best described by the negative binomial distribution; some hosts have many parasites while most have just a few. Thus identifying heterogeneities in parasite burdens using conventional parametric methods is problematical. In an attempt to conform to the assumptions of parametric analyses, parasitologists and ecologists frequently log-transform their overdispersed data prior to analysis. In this paper, we compare this method of analysis with an alternative, generalized linear modelling (GLM), approach. 2. We compare the classical linear model using log-transformed data (Model 1) with two GLMs: one with Poisson errors and an empirical scale parameter (Model 2), and one in which negative binomial errors are explicitly defined (Model 3). We use simulated datasets and empirical data from a long-term study of parasitism in Soay Sheep on St Kilda to test the efficacies of these three statistical models. 3. We conclude that Model 1 is much more likely to produce type I errors than either of the two GLMs, and that it also tends to produce more type II errors. Model 3 is only marginally more successful than Model 2, indicating that the use of an empirical scale parameter is only slightly more likely to generate errors than using an explicitly defined negative binomial distribution. Thus, while we strongly recommend the use of GLMs over conventional parametric analyses, either GLM method will serve equally well.

A bidirectional relationship between physical activity and executive function in older adults

Abstract: Physically active lifestyles contribute to better executive function. However, it is unclear whether high levels of executive function lead people to be more active. This study uses a large sample and multi-wave data to identify whether a reciprocal association exists between physical activity and executive function. Participants were 4555 older adults tracked across four waves of the English Longitudinal Study of Aging. In each wave executive function was assessed using a verbal fluency test and a letter cancelation task and participants reported their physical activity levels. Fixed effects regressions showed that changes in executive function corresponded with changes in physical activity. In longitudinal multilevel models low levels of physical activity led to subsequent declines in executive function. Importantly, poor executive function predicted reductions in physical activity over time. This association was found to be over 50% larger in magnitude than the contribution of physical activity to changes in executive function. This is the first study to identify evidence for a robust bidirectional link between executive function and physical activity in a large sample of older adults tracked over time.