Institution
University of Stuttgart
Education•Stuttgart, Germany•
About: University of Stuttgart is a education organization based out in Stuttgart, Germany. It is known for research contribution in the topics: Laser & Finite element method. The organization has 27715 authors who have published 56370 publications receiving 1363382 citations. The organization is also known as: Universität Stuttgart.
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Papers
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TL;DR: It is shown here that addition of Mn2+ greatly alleviates defects of pmr1 mutants in N-linked and O-linked protein glycosylation, and establishes a novel role of this secretory pathway pump in endoplasmic reticulum-associated processes.
Abstract: The yeast Ca2+ adenosine triphosphatase Pmr1, located in medial-Golgi, has been implicated in intracellular transport of Ca2+ and Mn2+ ions. We show here that addition of Mn2+ greatly alleviates defects of pmr1 mutants in N-linked and O-linked protein glycosylation. In contrast, accurate sorting of carboxypeptidase Y (CpY) to the vacuole requires a sufficient supply of intralumenal Ca2+. Most remarkably, pmr1 mutants are also unable to degrade CpY*, a misfolded soluble endoplasmic reticulum protein, and display phenotypes similar to mutants defective in the stress response to malfolded endoplasmic reticulum proteins. Growth inhibition of pmr1 mutants on Ca2+-deficient media is overcome by expression of other Ca2+ pumps, including a SERCA-type Ca2+ adenosine triphosphatase from rabbit, or by Vps10, a sorting receptor guiding non-native luminal proteins to the vacuole. Our analysis corroborates the dual function of Pmr1 in Ca2+ and Mn2+ transport and establishes a novel role of this secretory pathway pump in endoplasmic reticulum-associated processes.
367 citations
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TL;DR: A new fabrication method to produce homogeneously fluorescent nanodiamonds with high yields is described, and the whole fabrication yield of colloidal quasi-spherical nanod diamonds was several orders of magnitude higher than those previously reported starting from microdiamonds.
Abstract: A new fabrication method to produce homogeneously fluorescent nanodiamonds with high yields is described. The powder obtained by high energy ball milling of fluorescent high pressure, high temperature diamond microcrystals was converted in a pure concentrated aqueous colloidal dispersion of highly crystalline ultrasmall nanoparticles with a mean size less than or equal to 10 nm. The whole fabrication yield of colloidal quasi-spherical nanodiamonds was several orders of magnitude higher than those previously reported starting from microdiamonds. The results open up avenues for the industrial cost-effective production of fluorescent nanodiamonds with well-controlled properties.
366 citations
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TL;DR: In this paper, the relationship between two square-free cycle sets operating transitively on each other was investigated and a Galois theory between ideals of braces and quotient cycle sets was established.
366 citations
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TL;DR: In this paper, a single-photon source coupled to a silver nanowire excites single surface plasmon polaritons that exhibit both wave and particle properties, similar to those of single photons.
Abstract: When light interacts with metal surfaces, it excites electrons, which can form propagating excitation waves called surface plasmon polaritons. These collective electronic excitations can produce strong electric fields localized to subwavelength distance scales 1 , which makes surface plasmon polaritons interesting for several applications. Many of these potential uses, and in particular those related to quantum networks 2 , r equire a deep understanding of the fundamental quantum properties of surface plasmon polaritons. Remarkably, these collective electron states preserve many key quantum mechanical properties of the photons used to excite them, including entanglement 3,4 and sub-Poissonian statistics 5 . Here, we show that a single-photon source coupled to a silver nanowire excites single surface plasmon polaritons that exhibit both wave and particle properties, similar to those of single photons. Furthermore, the detailed analysis of the spectral interference pattern provides a new method to characterize the dimensions of metallic waveguides with nanometre accuracy.
366 citations
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TL;DR: The TNF-receptor-associated factor (TRAF) family is a phylogenetically conserved group of scaffold proteins that link receptors of the IL-1R/Toll and TNF receptor family to signalling cascades, leading to the activation of NF-κB and mitogen-activated protein kinases as discussed by the authors.
366 citations
Authors
Showing all 28043 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Michael Kramer | 167 | 1713 | 127224 |
Andrew G. Clark | 140 | 823 | 123333 |
Stephen D. Walter | 112 | 513 | 57012 |
Fedor Jelezko | 103 | 413 | 42616 |
Ulrich Gösele | 102 | 603 | 46223 |
Dirk Helbing | 101 | 642 | 56810 |
Ioan Pop | 101 | 1370 | 47540 |
Niyazi Serdar Sariciftci | 99 | 591 | 54055 |
Matthias Komm | 99 | 832 | 43275 |
Hans-Joachim Werner | 98 | 317 | 48508 |
Richard R. Ernst | 96 | 352 | 53100 |
Xiaoming Sun | 96 | 382 | 47153 |
Feng Chen | 95 | 2138 | 53881 |