Institution
University of Stuttgart
Education•Stuttgart, Germany•
About: University of Stuttgart is a education organization based out in Stuttgart, Germany. It is known for research contribution in the topics: Laser & Finite element method. The organization has 27715 authors who have published 56370 publications receiving 1363382 citations. The organization is also known as: Universität Stuttgart.
Papers published on a yearly basis
Papers
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TL;DR: In this article, a wide range of pulsating heat pipes is experimentally studied and the influence of gravity and number of turns on the performance of closed loop pulsing heat pipes (CLPHPs) is analyzed.
352 citations
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TL;DR: In this paper, the movement of pedestrians is assumed to be determined by an intended velocity, by several attractive and repulsive effects, and by fluctuations, which can be explicitly modeled.
Abstract: The movement of pedestrians is supposed to show certain regularities which can be best described by an “algorithm” for individual behavior and is easily simulated on computers. This behavior is assumed to be determined by an intended velocity, by several attractive and repulsive effects, and by fluctuations. The movement of pedestrians is dependent on decisions, which have the purpose of optimizing their behavior and can be explicitly modeled. Some interesting applications of the model to real situations are given, especially to formation of groups, behavior in queues, avoidance of collisions, and selection processes among behavioral alternatives.
350 citations
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TL;DR: This work demonstrates the applicability of correspondence analysis to and high value for the analysis of microarray data, displaying associations between genes and experiments and applies it to a non-time-series data set of its own.
Abstract: Correspondence analysis is an explorative computational method for the study of associations between variables. Much like principal component analysis, it displays a low-dimensional projection of the data, e.g., into a plane. It does this, though, for two variables simultaneously, thus revealing associations between them. Here, we demonstrate the applicability of correspondence analysis to and high value for the analysis of microarray data, displaying associations between genes and experiments. To introduce the method, we show its application to the well-known Saccharomyces cerevisiae cell-cycle synchronization data by Spellman et al. [Spellman, P. T., Sherlock, G., Zhang, M. Q., Iyer, V. R., Anders, K., Eisen, M. B., Brown, P. O., Botstein, D. & Futcher, B. (1998) Mol. Biol. Cell 9, 3273-3297], allowing for comparison with their visualization of this data set. Furthermore, we apply correspondence analysis to a non-time-series data set of our own, thus supporting its general applicability to microarray data of different complexity, underlying structure, and experimental strategy (both two-channel fluorescence-tag and radioactive labeling).
350 citations
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TL;DR: The key idea is to align the complexity level and order of analysis with the reliability and detail level of statistical information on the input parameters to avoid the necessity to assign parametric probability distributions that are not sufficiently supported by limited available data.
350 citations
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TL;DR: Der3p might serve as a component programming the translocon for retrograde transport of ER proteins, or it might be involved in recognition through its lumenal RING-H2 motif of proteins of the ER that are destined for degradation.
Abstract: We have studied components of the endoplasmic reticulum (ER) proofreading and degradation system in the yeast Saccharomyces cerevisiae. Using a der3–1 mutant defective in the degradation of a mutated lumenal protein, carboxypeptidase yscY (CPY*), a gene was cloned which encodes a 64-kDa protein of the ER membrane. Der3p was found to be identical with Hrd1p, a protein identified to be necessary for degradation of HMG-CoA reductase. Der3p contains five putative transmembrane domains and a long hydrophilic C-terminal tail containing a RING-H2 finger domain which is oriented to the ER lumen. Deletion of DER3 leads to an accumulation of CPY* inside the ER due to a complete block of its degradation. In addition, a DER3 null mutant allele suppresses the temperature-dependent growth phenotype of a mutant carrying the sec61–2 allele. This is accompanied by the stabilization of the Sec61–2 mutant protein. In contrast, overproduction of Der3p is lethal in a sec61–2 strain at the permissive temperature of 25°C. A mutant Der3p lacking 114 amino acids of the lumenal tail including the RING-H2 finger domain is unable to mediate degradation of CPY* and Sec61–2p. We propose that Der3p acts prior to retrograde transport of ER membrane and lumenal proteins to the cytoplasm where they are subject to degradation via the ubiquitin-proteasome system. Interestingly, in ubc6-ubc7 double mutants, CPY* accumulates in the ER, indicating the necessity of an intact cytoplasmic proteolysis machinery for retrograde transport of CPY*. Der3p might serve as a component programming the translocon for retrograde transport of ER proteins, or it might be involved in recognition through its lumenal RING-H2 motif of proteins of the ER that are destined for degradation.
349 citations
Authors
Showing all 28043 results
Name | H-index | Papers | Citations |
---|---|---|---|
Yi Chen | 217 | 4342 | 293080 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Michael Kramer | 167 | 1713 | 127224 |
Andrew G. Clark | 140 | 823 | 123333 |
Stephen D. Walter | 112 | 513 | 57012 |
Fedor Jelezko | 103 | 413 | 42616 |
Ulrich Gösele | 102 | 603 | 46223 |
Dirk Helbing | 101 | 642 | 56810 |
Ioan Pop | 101 | 1370 | 47540 |
Niyazi Serdar Sariciftci | 99 | 591 | 54055 |
Matthias Komm | 99 | 832 | 43275 |
Hans-Joachim Werner | 98 | 317 | 48508 |
Richard R. Ernst | 96 | 352 | 53100 |
Xiaoming Sun | 96 | 382 | 47153 |
Feng Chen | 95 | 2138 | 53881 |