University of Sussex

About: University of Sussex is a education organization based out in Brighton, United Kingdom. It is known for research contribution in the topics: Population & Galaxy. The organization has 17385 authors who have published 44685 publications receiving 2005538 citations.

The EAGLE project: Simulating the evolution and assembly of galaxies and their environments

Abstract: We introduce the Virgo Consortium's EAGLE project, a suite of hydrodynamical simulations that follow the formation of galaxies and black holes in representative volumes. We discuss the limitations of such simulations in light of their finite resolution and poorly constrained subgrid physics, and how these affect their predictive power. One major improvement is our treatment of feedback from massive stars and AGN in which thermal energy is injected into the gas without the need to turn off cooling or hydrodynamical forces, allowing winds to develop without predetermined speed or mass loading factors. Because the feedback efficiencies cannot be predicted from first principles, we calibrate them to the z~0 galaxy stellar mass function and the amplitude of the galaxy-central black hole mass relation, also taking galaxy sizes into account. The observed galaxy mass function is reproduced to ≲0.2 dex over the full mass range, 108

Review of Particle Physics

Abstract: This biennial Review summarizes much of particle physics. Using data from previous editions, plus 2158 new measurements from 551 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors, probability, and statistics. Among the 108 reviews are many that are new or heavily revised including those on neutrino mass, mixing, and oscillations, QCD, top quark, CKM quark-mixing matrix, V-ud & V-us, V-cb & V-ub, fragmentation functions, particle detectors for accelerator and non-accelerator physics, magnetic monopoles, cosmological parameters, and big bang cosmology.

The ‘National System of Innovation’ in historical perspective

Abstract: Contrary to some recent work on so-called 'globalisation', this paper argues that national and regional systems of innovation remain an essential domain of economic analysis. Their importance derives from the networks of relationships which are necessary for any firm to innovate. Whilst external international connections are certainly of growing importance, the influence of the national education system, industrial relations, technical and scientific institutions, government policies, cul- tural traditions and many other national institutions is fundamental. The historical examples of Germany, Japan and the former USSR illustrate this point, as well as the more recent contrast between East Asian and Latin American countries. Introduction: The National System of Friedrich List According to this author's recollections, the first person to use the expression 'National System of Innovation' was Bengt-Ake Lundvall and he is also the editor of a highly original and thought-provoking book (1992) on this subject. However, as he and his colleagues would be the first to agree (and as Lundvall himself points out) the idea actually goes back at least to Friedrich List's conception of "The National System of Political Economy' (1841), which might just as well have been called 'The National System of Innovation'. The main concern of List was with the problem of Germany overtaking England and, for underdeveloped countries (as Germany then was in relation to England), he advocated not only protection of infant industries but a broad range of policies designed to accelerate, or to make possible, industrialisation and economic growth. Most of these policies were concerned with learning about new technology and applying it. The racialist and colonialist overtones of the book were in strong contrast to the inter- nationalist cosmopolitan approach of the classical free trade economists and List's belief that Holland and Denmark should join the German 'Bund' and acquire German nationality because of their 'descent and whole character' reads somewhat strangely in the European Community of today. Nevertheless, despite these unattractive features of his outlook, he clearly anticipated many contemporary theories. After reviewing the changing ideas of economists about development in the years since the Second World War, the World Bank (1991) concludes that it is intangible investment in knowledge accumulation which is decisive rather than physical capital investment, as was at one time believed (pages 33-35). The Report cites the 'New Growth Theory'

A single ataxia telangiectasia gene with a product similar to pi-3 kinase

Abstract: A gene, ATM, that is mutated in the autosomal recessive disorder ataxia telangiectasia (AT) was identified by positional cloning on chromosome 11q22-23. AT is characterized by cerebellar degeneration, immunodeficiency, chromosomal instability, cancer predisposition, radiation sensitivity, and cell cycle abnormalities. The disease is genetically heterogeneous, with four complementation groups that have been suspected to represent different genes. ATM, which has a transcript of 12 kilobases, was found to be mutated in AT patients from all complementation groups, indicating that it is probably the sole gene responsible for this disorder. A partial ATM complementary DNA clone of 5.9 kilobases encoded a putative protein that is similar to several yeast and mammalian phosphatidylinositol-3' kinases that are involved in mitogenic signal transduction, meiotic recombination, and cell cycle control. The discovery of ATM should enhance understanding of AT and related syndromes and may allow the identification of AT heterozygotes, who are at increased risk of cancer.

The hitch-hiking effect of a favourable gene.

Abstract: SUMMARY When a selectively favourable gene substitution occurs in a population, changes in gene frequencies will occur at closely linked loci. In the case of a neutral polymorphism, average heterozygosity will be reduced to an extent which varies with distance from the substituted locus. The aggregate eifect of substitution on neutral polymorphism is estimated; in populations of total size 10 6 or more (and perhaps of 10 4 or more), this eifect will be more important than that of random fixation. This may explain why the extent of polymorphism in natural populations does not vary as much as one would expect from a consideration of the equilibrium between mutation and random fixation in populations of different sizes. For a selectively maintained polymorphism at a linked locus, this process will only be important in the long run if it leads to complete fixation. If the selective coefficients at the linked locus are small compared to those at the substituted locus, it is shown that the probability of complete fixation at the linked locus is approximately exp (— Nc), where c is the recombinant fraction and N the population size. It follows that in a large population a selective substitution can occur in a cistron without eliminating a selectively maintained polymorphism in the same cistron.