University of Tabriz

About: University of Tabriz is a education organization based out in Tabriz, Iran. It is known for research contribution in the topics: Population & Nanocomposite. The organization has 12141 authors who have published 20976 publications receiving 313982 citations.

Metal-based nanoparticles for bone tissue engineering.

Abstract: Tissue is vital to the organization of multicellular organisms, because it creates the different organs and provides the main scaffold for body shape. The quest for effective methods to allow tissue regeneration and create scaffolds for new tissue growth has intensified in recent years. Tissue engineering has recently used some promising alternatives to existing conventional scaffold materials, many of which have been derived from nanotechnology. One important example of these is metal nanoparticles. The purpose of this review is to cover novel tissue engineering methods, paying special attention to those based on the use of metal-based nanoparticles. The unique physiochemical properties of metal nanoparticles, such as antibacterial effects, shape memory phenomenon, low cytotoxicity, stimulation of the proliferation process, good mechanical and tensile strength, acceptable biocompatibility, significant osteogenic potential, and ability to regulate cell growth pathways, suggest that they can perform as novel types of scaffolds for bone tissue engineering. The basic principles of various nanoparticle-based composites and scaffolds are discussed in this review. The merits and demerits of these particles are critically discussed, and their importance in bone tissue engineering is highlighted.

Risk-Based Electricity Procurement for Large Consumers

Abstract: In a competitive electricity market, consumers seek strategies to procure their energy needs from different resources (pool, bilateral contracts, and their own generation facilities) at minimum cost while controlling the risk. In this paper, a novel method is proposed to address the electricity procurement problem of large consumers using the concept of information gap decision theory. The method can be used as a tool for assessing the risk levels, considering whether a large consumer is risk-taking or risk-averse regarding its midterm procurement strategies. In the proposed method, procurement decisions are evaluated by means of two criteria. The first criterion is the robustness of the decision against experiencing high procurement costs, and the second one is the opportunity of taking advantage of low procurement costs. The pool price is considered an uncertain variable, and it is assumed that the large consumer has an estimate of the prices. In this study, two models of uncertainty are addressed for the pool price based on the concept of weighted mean squared error using a variance-covariance matrix, and the expected procurement cost is modeled using a joint normal probability distribution function. A case study illustrates the working of the proposed technique.

Curcumin Activates the Nrf2 Pathway and Induces Cellular Protection Against Oxidative Injury

Abstract: Curcumin is a naturally occurring polyphenol that is isolated from the rhizome of Curcuma longa (turmeric). This medicinal compound has different biological activities, including antioxidant, antibacterial, antineoplastic, and anti-inflammatory. It also has therapeutic effects on neurodegenerative disorders, renal disorders, and diabetes mellitus. Curcumin is safe and well-tolerated at high concentrations without inducing toxicity. It seems that curcumin is capable of targeting the Nrf2 signaling pathway in protecting the cells against oxidative damage. Besides, this strategy is advantageous in cancer therapy. Accumulating data demonstrates that curcumin applies four distinct ways to stimulate the Nrf2 signaling pathway, including inhibition of Keap1, affecting the upstream mediators of Nrf2, influencing the expression of Nrf2 and target genes, and finally, improving the nuclear translocation of Nrf2. In the present review, the effects of curcumin on the Nrf2 signaling pathway to exert its therapeutic and biological activities has been discussed.