Institution
University of Tennessee Health Science Center
Education•Memphis, Tennessee, United States•
About: University of Tennessee Health Science Center is a education organization based out in Memphis, Tennessee, United States. It is known for research contribution in the topics: Population & Medicine. The organization has 15716 authors who have published 26884 publications receiving 1176697 citations.
Topics: Population, Medicine, Transplantation, Cancer, Gene
Papers published on a yearly basis
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TL;DR: The main lines of evidence are assembled that suggest the presence of several novel subtypes for both D1 and D2 dopamine receptors and it is predicted that molecular cloning will, in the near future, confirm their existence.
296 citations
TL;DR: The data suggest that VEGF may modulate endothelial cell-derived MMP activity by increasing the abundance of gelatinase A; disinhibiting gelatinases A by decreasing the abundanceof TIMP-2; and disinhibititing preexisting collagenase by reducing levels of TIMP -1.
296 citations
TL;DR: The relationship between indicators of inflammation and the incidence of mobility limitation in older persons is examined to find out if inflammation and mobility limitation are driven by different underlying mechanisms.
Abstract: OBJECTIVES: To examine the relationship between indicators of inflammation and the incidence of mobility limitation in older persons. DESIGN: Prospective cohort study: the Health, Aging and Body Composition Study. SETTING: Pittsburgh, Pennsylvania, and Memphis, Tennessee. PARTICIPANTS: A total of 2,979 men and women, aged 70 to 79, without mobility limitation at baseline. MEASUREMENTS: Serum levels of interleukin (IL)-6, tumor necrosis factor alpha (TNFa), and C-reactive protein (CRP) and soluble cytokine receptors (IL-2sR, IL-6sR, TNFsR1, TNFsR2) were measured. Mobility limitation was assessed and defined as reporting difficulty or inability to walk one-quarter of a mile or to climb 10 steps during two consecutive semiannual assessments over 30 months. RESULTS: Of the 2,979 participants, 30.1% developed incident mobility limitation. After adjustment for confounders (demographics, prevalent conditions at baseline, body composition), the relative risk (RR) of incident mobility limitation per standard deviation (SD) increase was 1.19 (95% confidence interval (CI) 51.10‐1.28) for IL-6, 1.20 (95% CI 51.12‐1.29) for TNFa, and 1.40 (95% CI 51.18‐1.68) for CRP. The association between inflammation and incident mobility limitation was especially strong for the onset of more severe mobility limitation and when the levels of multiple inflammatory markers were high. When persons with baseline or incident cardiovascular disease events or persons who were hospitalized during study follow-up were excluded, findings remained similar. In a subset (n 5499), high levels of the soluble receptors IL2sR and TNFsR1 (per SD increase: RR 51.23 (95% CI 51.04‐1.46) and RR 51.28 (95% CI 51.04‐ 1.57), respectively) were also associated with incident mobility limitation. CONCLUSION: Findings suggest that inflammation is prognostic for incident mobility limitation over 30 months, independent of cardiovascular disease events and incident severe illness. J Am Geriatr Soc 52:1105‐1113, 2004.
295 citations
Boston University1, Montreal Children's Hospital2, Canadian Blood Services3, New York University4, Albany Medical College5, University of Chicago6, Dartmouth College7, University of Washington8, Hacettepe University9, University of Tennessee Health Science Center10, University of Pittsburgh11, Northwestern University12, University of Milano-Bicocca13, Universidad del Desarrollo14, University of Sydney15, Southmead Hospital16, University of Florida17, William Mitchell College of Law18, University of Melbourne19, University of Cape Town20, Dubai Hospital21, University of Valencia22, University of Toronto23, The Queen's Medical Center24, University of Texas Health Science Center at Houston25, Seoul National University Bundang Hospital26, Sir Charles Gairdner Hospital27, Texas A&M University28, Kagawa University29, Capital Medical University30, Tribhuvan University31, Indiana University – Purdue University Indianapolis32, Montreal Neurological Institute and Hospital33, Ruby Hall Clinic34, University of Southern California35
TL;DR: Recommendations are provided for the minimum clinical standards for determination of brain death/death by neurologic criteria in adults and children with clear guidance for various clinical circumstances and have widespread international society endorsement.
Abstract: Importance There are inconsistencies in concept, criteria, practice, and documentation of brain death/death by neurologic criteria (BD/DNC) both internationally and within countries. Objective To formulate a consensus statement of recommendations on determination of BD/DNC based on review of the literature and expert opinion of a large multidisciplinary, international panel. Process Relevant international professional societies were recruited to develop recommendations regarding determination of BD/DNC. Literature searches of the Cochrane, Embase, and MEDLINE databases included January 1, 1992, through April 2020 identified pertinent articles for review. Because of the lack of high-quality data from randomized clinical trials or large observational studies, recommendations were formulated based on consensus of contributors and medical societies that represented relevant disciplines, including critical care, neurology, and neurosurgery. Evidence Synthesis Based on review of the literature and consensus from a large multidisciplinary, international panel, minimum clinical criteria needed to determine BD/DNC in various circumstances were developed. Recommendations Prior to evaluating a patient for BD/DNC, the patient should have an established neurologic diagnosis that can lead to the complete and irreversible loss of all brain function, and conditions that may confound the clinical examination and diseases that may mimic BD/DNC should be excluded. Determination of BD/DNC can be done with a clinical examination that demonstrates coma, brainstem areflexia, and apnea. This is seen when (1) there is no evidence of arousal or awareness to maximal external stimulation, including noxious visual, auditory, and tactile stimulation; (2) pupils are fixed in a midsize or dilated position and are nonreactive to light; (3) corneal, oculocephalic, and oculovestibular reflexes are absent; (4) there is no facial movement to noxious stimulation; (5) the gag reflex is absent to bilateral posterior pharyngeal stimulation; (6) the cough reflex is absent to deep tracheal suctioning; (7) there is no brain-mediated motor response to noxious stimulation of the limbs; and (8) spontaneous respirations are not observed when apnea test targets reach pH Conclusions and Relevance This report provides recommendations for the minimum clinical standards for determination of brain death/death by neurologic criteria in adults and children with clear guidance for various clinical circumstances. The recommendations have widespread international society endorsement and can serve to guide professional societies and countries in the revision or development of protocols and procedures for determination of brain death/death by neurologic criteria, leading to greater consistency within and between countries.
295 citations
Pohang University of Science and Technology1, Harvard University2, Jagiellonian University3, Utrecht University4, Lund University5, North Shore-LIJ Health System6, Morehouse School of Medicine7, National Research Council8, Autonomous University of Barcelona9, French Institute of Health and Medical Research10, Semmelweis University11, University of Melbourne12, Cardiff University13, Yale University14, University of Tennessee Health Science Center15, Cedars-Sinai Medical Center16, University of Gothenburg17, University of Oxford18, University of Duisburg-Essen19, La Trobe University20, German Cancer Research Center21, Ghent University22, University of Queensland23, Seoul National University24, London Metropolitan University25, Council of Scientific and Industrial Research26, Mayo Clinic27, Dankook University28, Aalborg University29, Kyung Hee University30, Ewha Womans University31, University of Toronto32, Erasmus University Rotterdam33, Temple University34, University of Pennsylvania35, University of Valencia36, QIMR Berghofer Medical Research Institute37, Université catholique de Louvain38, University of Freiburg39, University of Amsterdam40, Walter and Eliza Hall Institute of Medical Research41, Oswaldo Cruz Foundation42, Federal University of Rio de Janeiro43, Icahn School of Medicine at Mount Sinai44, University of California, Los Angeles45, University of Helsinki46, Queensland University of Technology47, Washington University in St. Louis48, Hiroshima University49, Hannover Medical School50, Umeå University51, Johns Hopkins University52, Ludwig Maximilian University of Munich53
TL;DR: An improved version of EVpedia, a public database for EVs research, is presented, which contains a database of publications and vesicular components, identification of orthologous vesicle components, bioinformatic tools and a personalized function.
Abstract: Motivation: Extracellular vesicles (EVs) are spherical bilayered proteolipids, harboring various bioactive molecules. Due to the complexity of the vesicular nomenclatures and components, online searches for EV-related publications and vesicular components are currently challenging.
Results: We present an improved version of EVpedia, a public database for EVs research. This community web portal contains a database of publications and vesicular components, identification of orthologous vesicular components, bioinformatic tools and a personalized function. EVpedia includes 6879 publications, 172 080 vesicular components from 263 high-throughput datasets, and has been accessed more than 65 000 times from more than 750 cities. In addition, about 350 members from 73 international research groups have participated in developing EVpedia. This free web-based database might serve as a useful resource to stimulate the emerging field of EV research.
Availability and implementation: The web site was implemented in PHP, Java, MySQL and Apache, and is freely available at http://evpedia.info.
294 citations
Authors
Showing all 15827 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| George P. Chrousos | 169 | 1612 | 120752 |
| Steven N. Blair | 165 | 879 | 132929 |
| Bruce L. Miller | 163 | 1153 | 115975 |
| Ralph A. DeFronzo | 160 | 759 | 132993 |
| Frank J. Gonzalez | 160 | 1144 | 96971 |
| Robert G. Webster | 158 | 843 | 90776 |
| Anne B. Newman | 150 | 902 | 99255 |
| Ching-Hon Pui | 145 | 805 | 72146 |
| Barton F. Haynes | 144 | 911 | 79014 |
| Yoshihiro Kawaoka | 139 | 883 | 75087 |
| Seth M. Steinberg | 137 | 936 | 80148 |
| Richard J. Johnson | 137 | 880 | 72201 |
| Kristine Yaffe | 136 | 794 | 72250 |
| Leslie L. Robison | 131 | 854 | 64373 |
| Gerardo Heiss | 128 | 623 | 69393 |