Institution
University of Texas at Austin
Education•Austin, Texas, United States•
About: University of Texas at Austin is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 94352 authors who have published 206297 publications receiving 9070052 citations. The organization is also known as: UT-Austin & UT Austin.
Topics: Population, Poison control, Galaxy, Context (language use), Stars
Papers published on a yearly basis
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TL;DR: Leptin-replacement therapy improved glycemic control and decreased triglyceride levels in patients with lipodystrophy and leptin deficiency and was well tolerated.
Abstract: Background The adipocyte hormone leptin is important in regulating energy homeostasis. Since severe lipodystrophy is associated with leptin deficiency, insulin resistance, hypertriglyceridemia, and hepatic steatosis, we assessed whether leptin replacement would ameliorate this condition. Methods Nine female patients (age range, 15 to 42 years; eight with diabetes mellitus) who had lipodystrophy and serum leptin levels of less than 4 ng per milliliter (0.32 nmol per milliliter) received recombinant methionyl human leptin (recombinant leptin). Recombinant leptin was administered subcutaneously twice a day for four months at escalating doses to achieve low, intermediate, and high physiologic replacement levels of leptin. Results During treatment with recombinant leptin, the serum leptin level increased from a mean (±SE) of 1.3±0.3 ng per milliliter to 11.1±2.5 ng per milliliter (0.1±0.02 to 0.9±0.2 nmol per milliliter). The absolute decrease in the glycosylated hemoglobin value was 1.9 percent (95 percent co...
1,105 citations
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University of Tokyo1, University of Wisconsin-Madison2, University of Toronto3, University of Kentucky4, University of Texas at Austin5, University of Washington6, University of St Andrews7, University of Portsmouth8, European Southern Observatory9, University of Nottingham10, National Autonomous University of Mexico11, University of Pittsburgh12, University of Cambridge13, New Mexico State University14, Carnegie Institution for Science15, University of Sydney16, New York University17, University of Utah18, University of Oxford19, University of California, Santa Cruz20, Max Planck Society21, École normale supérieure de Lyon22, Claude Bernard University Lyon 123, Texas Christian University24, University of Iowa25, Princeton University26, Case Western Reserve University27, University of La Laguna28, Chinese Academy of Sciences29, Academia Sinica30, University of Manchester31, Australian Astronomical Observatory32, Macquarie University33, Yale University34, Lawrence Berkeley National Laboratory35, University of Potsdam36, University of Victoria37, University of Groningen38
TL;DR: MaNGA (Mapping Nearby Galaxies at Apache Point Observatory) as mentioned in this paper employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers).
Abstract: We present an overview of a new integral field spectroscopic survey called MaNGA (Mapping Nearby Galaxies at Apache Point Observatory), one of three core programs in the fourth-generation Sloan Digital Sky Survey (SDSS-IV) that began on 2014 July 1. MaNGA will investigate the internal kinematic structure and composition of gas and stars in an unprecedented sample of 10,000 nearby galaxies. We summarize essential characteristics of the instrument and survey design in the context of MaNGA's key science goals and present prototype observations to demonstrate MaNGA's scientific potential. MaNGA employs dithered observations with 17 fiber-bundle integral field units that vary in diameter from 12'' (19 fibers) to 32'' (127 fibers). Two dual-channel spectrographs provide simultaneous wavelength coverage over 3600-10300 A at R ~ 2000. With a typical integration time of 3 hr, MaNGA reaches a target r-band signal-to-noise ratio of 4-8 (A–1 per 2'' fiber) at 23 AB mag arcsec–2, which is typical for the outskirts of MaNGA galaxies. Targets are selected with M * 109 M ☉ using SDSS-I redshifts and i-band luminosity to achieve uniform radial coverage in terms of the effective radius, an approximately flat distribution in stellar mass, and a sample spanning a wide range of environments. Analysis of our prototype observations demonstrates MaNGA's ability to probe gas ionization, shed light on recent star formation and quenching, enable dynamical modeling, decompose constituent components, and map the composition of stellar populations. MaNGA's spatially resolved spectra will enable an unprecedented study of the astrophysics of nearby galaxies in the coming 6 yr.
1,104 citations
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TL;DR: This paper seeks to reconcile and integrate two independent research efforts into a significantly evolved functional basis, and provides a mechanism for evaluating whether future revisions are needed to the functional basis and, if so, how to proceed.
Abstract: In engineering design, all products and artifacts have some intended reason behind their existence: the product or artifact function. Functional modeling provides an abstract, yet direct, method for understanding and representing an overall product or artifact function. Functional modeling also strategically guides design activities such as problem decomposition, physical modeling, product architecting, concept generation, and team organization. A formal function representation is needed to support functional modeling, and a standardized set of function-related terminology leads to repeatable and meaningful results from such a representation. We refer to this representation as a functional basis; in this paper, we seek to reconcile and integrate two independent research efforts into a significantly evolved functional basis. These efforts include research from the National Institute of Standards and Technology and two US universities, and their industrial partners. The overall approach for integrating the functional representations and the final results are presented. This approach also provides a mechanism for evaluating whether future revisions are needed to the functional basis and, if so, how to proceed. The integration process is discussed relative to differences, similarities, insights into the representations, and product validation. Based on the results, a more versatile and comprehensive design vocabulary emerges. This vocabulary will greatly enhance and expand the frontiers of research in design repositories, product architecture, design synthesis, and general product modeling.
1,104 citations
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01 Jan 19701,104 citations
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University College London1, University of Cambridge2, University of California, Irvine3, University of Maryland, College Park4, University of Oxford5, Smithsonian Institution6, University of Greifswald7, Max Planck Society8, Imperial College London9, Harvard University10, University of East Anglia11, Mississippi State University12, University of Texas at Austin13, Commonwealth Scientific and Industrial Research Organisation14, University of Paris15, University of Hawaii16, California Academy of Sciences17, Williams College18, Yale University19, University of Puerto Rico20, Johns Hopkins University21, North Carolina State University22, University of Bristol23, University of Edinburgh24, Baylor College of Medicine25, Del Rosario University26, University of Exeter27, Boston University28
TL;DR: It is inferred that closely related Heliconius species exchange protective colour-pattern genes promiscuously, implying that hybridization has an important role in adaptive radiation.
Abstract: Sequencing of the genome of the butterfly Heliconius melpomene shows that closely related Heliconius species exchange protective colour-pattern genes promiscuously.
1,103 citations
Authors
Showing all 95138 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Eugene Braunwald | 230 | 1711 | 264576 |
Yi Chen | 217 | 4342 | 293080 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Joseph L. Goldstein | 207 | 556 | 149527 |
Eric N. Olson | 206 | 814 | 144586 |
Hagop M. Kantarjian | 204 | 3708 | 210208 |
Rakesh K. Jain | 200 | 1467 | 177727 |
Francis S. Collins | 196 | 743 | 250787 |
Gordon B. Mills | 187 | 1273 | 186451 |
Scott M. Grundy | 187 | 841 | 231821 |
Michael S. Brown | 185 | 422 | 123723 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Aaron R. Folsom | 181 | 1118 | 134044 |
Jiaguo Yu | 178 | 730 | 113300 |