Institution
University of Texas at Austin
Education•Austin, Texas, United States•
About: University of Texas at Austin is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 94352 authors who have published 206297 publications receiving 9070052 citations. The organization is also known as: UT-Austin & UT Austin.
Topics: Population, Poison control, Galaxy, Context (language use), Stars
Papers published on a yearly basis
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Scottish Association for Marine Science1, Ulster University2, Nelson Mandela Metropolitan University3, University of North Carolina at Chapel Hill4, Edith Cowan University5, Aberystwyth University6, Commonwealth Scientific and Industrial Research Organisation7, Technical University of Denmark8, University of Queensland9, University of Western Australia10, Spanish National Research Council11, University of California, Santa Barbara12, Museum für Naturkunde13, University of British Columbia14, University of Texas at Austin15, National Oceanic and Atmospheric Administration16
TL;DR: Two measures of thermal shifts from analyses of global temperatures over the past 50 years are used to describe the pace of climate change that species should track: the velocity ofClimate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures.
Abstract: Climate change challenges organisms to adapt or move to track changes in environments in space and time. We used two measures of thermal shifts from analyses of global temperatures over the past 50 years to describe the pace of climate change that species should track: the velocity of climate change (geographic shifts of isotherms over time) and the shift in seasonal timing of temperatures. Both measures are higher in the ocean than on land at some latitudes, despite slower ocean warming. These indices give a complex mosaic of predicted range shifts and phenology changes that deviate from simple poleward migration and earlier springs or later falls. They also emphasize potential conservation concerns, because areas of high marine biodiversity often have greater velocities of climate change and seasonal shifts.
1,101 citations
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TL;DR: Associations between inherited cellular transport gene variants and risk of EOC histologic subtypes are revealed on a large cohort of women.
Abstract: BACKGROUND: Defective cellular transport processes can lead to aberrant accumulation of trace elements, iron, small molecules and hormones in the cell, which in turn may promote the formation of reactive oxygen species, promoting DNA damage and aberrant expression of key regulatory cancer genes. As DNA damage and uncontrolled proliferation are hallmarks of cancer, including epithelial ovarian cancer (EOC), we hypothesized that inherited variation in the cellular transport genes contributes to EOC risk. METHODS: In total, DNA samples were obtained from 14,525 case subjects with invasive EOC and from 23,447 controls from 43 sites in the Ovarian Cancer Association Consortium (OCAC). Two hundred seventy nine SNPs, representing 131 genes, were genotyped using an Illumina Infinium iSelect BeadChip as part of the Collaborative Oncological Gene-environment Study (COGS). SNP analyses were conducted using unconditional logistic regression under a log-additive model, and the FDR q<0.2 was applied to adjust for multiple comparisons. RESULTS: The most significant evidence of an association for all invasive cancers combined and for the serous subtype was observed for SNP rs17216603 in the iron transporter gene HEPH (invasive: OR = 0.85, P = 0.00026; serous: OR = 0.81, P = 0.00020); this SNP was also associated with the borderline/low malignant potential (LMP) tumors (P = 0.021). Other genes significantly associated with EOC histological subtypes (p<0.05) included the UGT1A (endometrioid), SLC25A45 (mucinous), SLC39A11 (low malignant potential), and SERPINA7 (clear cell carcinoma). In addition, 1785 SNPs in six genes (HEPH, MGST1, SERPINA, SLC25A45, SLC39A11 and UGT1A) were imputed from the 1000 Genomes Project and examined for association with INV EOC in white-European subjects. The most significant imputed SNP was rs117729793 in SLC39A11 (per allele, OR = 2.55, 95% CI = 1.5-4.35, p = 5.66x10-4). CONCLUSION: These results, generated on a large cohort of women, revealed associations between inherited cellular transport gene variants and risk of EOC histologic subtypes.
1,100 citations
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TL;DR: In this paper, the authors measured the laser heating and monitoring the Raman G peak and obtained room-temperature thermal conductivity and interface conductance of (370 + 650/−320) W/m K and (28 + 16/−9.2) MW/m2 K for the supported graphene.
Abstract: Graphene monolayer has been grown by chemical vapor deposition on copper and then suspended over a hole. By measuring the laser heating and monitoring the Raman G peak, we obtain room-temperature thermal conductivity and interface conductance of (370 + 650/−320) W/m K and (28 + 16/−9.2) MW/m2 K for the supported graphene. The thermal conductivity of the suspended graphene exceeds (2500 + 1100/−1050) W/m K near 350 K and becomes (1400 + 500/−480) W/m K at about 500 K.
1,100 citations
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National and Kapodistrian University of Athens1, Karolinska University Hospital2, University of Navarra3, University of Calgary4, University College London5, University of Texas at Austin6, Poznan University of Medical Sciences7, New Generation University College8, Hadassah Medical Center9, Harvard University10, University Hospital Heidelberg11, German Cancer Research Center12, Princess Margaret Cancer Centre13, Genmab14, Janssen Pharmaceutica15
TL;DR: The addition of daratumumab to lenalidomide and dexamethasone significantly lengthened progression-free survival among patients with relapsed or refractory multiple myeloma.
Abstract: BackgroundDaratumumab showed promising efficacy alone and with lenalidomide and dexamethasone in a phase 1–2 study involving patients with relapsed or refractory multiple myeloma. MethodsIn this phase 3 trial, we randomly assigned 569 patients with multiple myeloma who had received one or more previous lines of therapy to receive lenalidomide and dexamethasone either alone (control group) or in combination with daratumumab (daratumumab group). The primary end point was progression-free survival. ResultsAt a median follow-up of 13.5 months in a protocol-specified interim analysis, 169 events of disease progression or death were observed (in 53 of 286 patients [18.5%] in the daratumumab group vs. 116 of 283 [41.0%] in the control group; hazard ratio, 0.37; 95% confidence interval [CI], 0.27 to 0.52; P<0.001 by stratified log-rank test). The Kaplan–Meier rate of progression-free survival at 12 months was 83.2% (95% CI, 78.3 to 87.2) in the daratumumab group, as compared with 60.1% (95% CI, 54.0 to 65.7) in t...
1,100 citations
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TL;DR: In this article, the authors define a statistical model allowing determination of the statistical properties of the nonparametric estimators in the multi-output and multi-input case, and provide the asymptotic sampling distribution of the FDH estimator in a multivariate setting and of the DEA estimator for the bivariate case.
Abstract: Efficiency scores of firms are measured by their distance to an estimated production frontier. The economic literature proposes several nonparametric frontier estimators based on the idea of enveloping the data (FDH and DEA-type estimators). Many have claimed that FDH and DEA techniques are non-statistical, as opposed to econometric approaches where particular parametric expressions are posited to model the frontier. We can now define a statistical model allowing determination of the statistical properties of the nonparametric estimators in the multi-output and multi-input case. New results provide the asymptotic sampling distribution of the FDH estimator in a multivariate setting and of the DEA estimator in the bivariate case. Sampling distributions may also be approximated by bootstrap distributions in very general situations. Consequently, statistical inference based on DEA/FDH-type estimators is now possible. These techniques allow correction for the bias of the efficiency estimators and estimation of confidence intervals for the efficiency measures. This paper summarizes the results which are now available, and provides a brief guide to the existing literature. Emphasizing the role of hypotheses and inference, we show how the results can be used or adapted for practical purposes.
1,099 citations
Authors
Showing all 95138 results
Name | H-index | Papers | Citations |
---|---|---|---|
George M. Whitesides | 240 | 1739 | 269833 |
Eugene Braunwald | 230 | 1711 | 264576 |
Yi Chen | 217 | 4342 | 293080 |
Robert J. Lefkowitz | 214 | 860 | 147995 |
Joseph L. Goldstein | 207 | 556 | 149527 |
Eric N. Olson | 206 | 814 | 144586 |
Hagop M. Kantarjian | 204 | 3708 | 210208 |
Rakesh K. Jain | 200 | 1467 | 177727 |
Francis S. Collins | 196 | 743 | 250787 |
Gordon B. Mills | 187 | 1273 | 186451 |
Scott M. Grundy | 187 | 841 | 231821 |
Michael S. Brown | 185 | 422 | 123723 |
Eric Boerwinkle | 183 | 1321 | 170971 |
Aaron R. Folsom | 181 | 1118 | 134044 |
Jiaguo Yu | 178 | 730 | 113300 |