University of Texas at Austin

About: University of Texas at Austin is a education organization based out in Austin, Texas, United States. It is known for research contribution in the topics: Population & Poison control. The organization has 94352 authors who have published 206297 publications receiving 9070052 citations. The organization is also known as: UT-Austin & UT Austin.

Arginine metabolism and nutrition in growth, health and disease

Abstract: l-Arginine (Arg) is synthesised from glutamine, glutamate, and proline via the intestinal-renal axis in humans and most other mammals (including pigs, sheep and rats). Arg degradation occurs via multiple pathways that are initiated by arginase, nitric-oxide synthase, Arg:glycine amidinotransferase, and Arg decarboxylase. These pathways produce nitric oxide, polyamines, proline, glutamate, creatine, and agmatine with each having enormous biological importance. Arg is also required for the detoxification of ammonia, which is an extremely toxic substance for the central nervous system. There is compelling evidence that Arg regulates interorgan metabolism of energy substrates and the function of multiple organs. The results of both experimental and clinical studies indicate that Arg is a nutritionally essential amino acid (AA) for spermatogenesis, embryonic survival, fetal and neonatal growth, as well as maintenance of vascular tone and hemodynamics. Moreover, a growing body of evidence clearly indicates that dietary supplementation or intravenous administration of Arg is beneficial in improving reproductive, cardiovascular, pulmonary, renal, gastrointestinal, liver and immune functions, as well as facilitating wound healing, enhancing insulin sensitivity, and maintaining tissue integrity. Additionally, Arg or l-citrulline may provide novel and effective therapies for obesity, diabetes, and the metabolic syndrome. The effect of Arg in treating many developmental and health problems is unique among AAs, and offers great promise for improved health and wellbeing of humans and animals.

Ultrasound-enhanced systemic thrombolysis for acute ischemic stroke.

Abstract: BACKGROUND Transcranial Doppler ultrasonography that is aimed at residual obstructive intracranial blood flow may help expose thrombi to tissue plasminogen activator (t-PA). Our objective was to determine whether ultrasonography can safely enhance the thrombolytic activity of t-PA. METHODS We treated all patients who had acute ischemic stroke due to occlusion of the middle cerebral artery with intravenous t-PA within three hours after the onset of symptoms. The patients were randomly assigned to receive continuous 2-MHz transcranial Doppler ultrasonography (the target group) or placebo (the control group). The primary combined end point was complete recanalization as assessed by transcranial Doppler ultrasonography or dramatic clinical recovery. Secondary end points included recovery at 24 hours, a favorable outcome at three months, and death at three months. RESULTS A total of 126 patients were randomly assigned to receive continuous ultrasonography (63 patients) or placebo (63 patients). Symptomatic intracerebral hemorrhage occurred in three patients in the target group and in three in the control group. Complete recanalization or dramatic clinical recovery within two hours after the administration of a t-PA bolus occurred in 31 patients in the target group (49 percent), as compared with 19 patients in the control group (30 percent; P=0.03). Twenty-four hours after treatment of the patients eligible for follow-up, 24 in the target group (44 percent) and 21 in the control group (40 percent) had dramatic clinical recovery (P=0.7). At three months, 22 of 53 patients in the target group who were eligible for follow-up analysis (42 percent) and 14 of 49 in the control group (29 percent) had favorable outcomes (as indicated by a score of 0 to 1 on the modified Rankin scale) (P=0.20). CONCLUSIONS In patients with acute ischemic stroke, continuous transcranial Doppler augments t-PA-induced arterial recanalization, with a nonsignificant trend toward an increased rate of recovery from stroke, as compared with placebo.

Adaptive duplicate detection using learnable string similarity measures

Abstract: The problem of identifying approximately duplicate records in databases is an essential step for data cleaning and data integration processes. Most existing approaches have relied on generic or manually tuned distance metrics for estimating the similarity of potential duplicates. In this paper, we present a framework for improving duplicate detection using trainable measures of textual similarity. We propose to employ learnable text distance functions for each database field, and show that such measures are capable of adapting to the specific notion of similarity that is appropriate for the field's domain. We present two learnable text similarity measures suitable for this task: an extended variant of learnable string edit distance, and a novel vector-space based measure that employs a Support Vector Machine (SVM) for training. Experimental results on a range of datasets show that our framework can improve duplicate detection accuracy over traditional techniques.

Gene Flow in Seed Plants

Abstract: Gene dispersal (flow, or migration) within and between plant populations has been of continuous interest to plant breeders and seed producers for many decades. Economic considerations have stimulated studies of gene flow as a function of distance, breeding system, pollinating agent, and planting design in numerous domestic plants. Only during the past two decades have a large body of plant evolutionists become interested in information accruing from these studies, and in the rates of gene flow in wild populations. Their efforts have concentrated primarily on related problems such as adaptations for and mechanics of pollen and seed (or fruit) dispersal, plant-pollinator coevolution, adaptive radiation in pollination and seed dispersal mechanisms, and colonization and the alteration of species boundaries. Early in this century, anecdoctal evidence on the movement of pollen and seed vectors, dispersal of pollen by wind, and the range extensions of weed species led to the casual assumption that gene flow must be extensive, and that it must play a major role in the cohesion of populations and population systems. This view eroded as more information became available and was more critically interpreted (e.g., Grant, 1958, 1971; Ehrlich and Raven, 1969; Stebbins, 1970a; Bradshaw, 1972).