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University of Texas MD Anderson Cancer Center

HealthcareHouston, Texas, United States
About: University of Texas MD Anderson Cancer Center is a(n) healthcare organization based out in Houston, Texas, United States. It is known for research contribution in the topic(s): Cancer & Breast cancer. The organization has 42125 authors who have published 92530 publication(s) receiving 4737934 citation(s). more

Topics: Cancer, Breast cancer, Population more

Showing all 42125 results

Eric S. Lander301826525976
Eric N. Olson206814144586
Hagop M. Kantarjian2043708210208
Matthew Meyerson194553243726
Dennis W. Dickson1911243148488
Gad Getz189520247560
Gordon B. Mills1871273186451
Douglas R. Green182661145944
Kenneth C. Anderson1781138126072
Bharat B. Aggarwal175706116213
John D. Minna169951106363
Gabriel N. Hortobagyi1661374104845
James G. Fujimoto1651115116451
Jorge E. Cortes1632784124154
Michael R. Stratton161443142586

Journal ArticleDOI: 10.1080/14653240600855905
01 Jan 2006-Cytotherapy
Abstract: The considerable therapeutic potential of human multipotent mesenchymal stromal cells (MSC) has generated markedly increasing interest in a wide variety of biomedical disciplines. However, investig... more

12,805 Citations

Open accessJournal ArticleDOI: 10.1038/NATURE15393
Adam Auton1, Gonçalo R. Abecasis2, David Altshuler3, Richard Durbin4  +514 moreInstitutions (90)
01 Oct 2015-Nature
Abstract: The 1000 Genomes Project set out to provide a comprehensive description of common human genetic variation by applying whole-genome sequencing to a diverse set of individuals from multiple populations. Here we report completion of the project, having reconstructed the genomes of 2,504 individuals from 26 populations using a combination of low-coverage whole-genome sequencing, deep exome sequencing, and dense microarray genotyping. We characterized a broad spectrum of genetic variation, in total over 88 million variants (84.7 million single nucleotide polymorphisms (SNPs), 3.6 million short insertions/deletions (indels), and 60,000 structural variants), all phased onto high-quality haplotypes. This resource includes >99% of SNP variants with a frequency of >1% for a variety of ancestries. We describe the distribution of genetic variation across the global sample, and discuss the implications for common disease studies. more

Topics: 1000 Genomes Project (62%), Exome sequencing (59%), Genome-wide association study (59%) more

9,821 Citations

Open accessJournal ArticleDOI: 10.1038/NATURE11412
04 Oct 2012-Nature
Abstract: We analysed primary breast cancers by genomic DNA copy number arrays, DNA methylation, exome sequencing, messenger RNA arrays, microRNA sequencing and reverse-phase protein arrays. Our ability to integrate information across platforms provided key insights into previously defined gene expression subtypes and demonstrated the existence of four main breast cancer classes when combining data from five platforms, each of which shows significant molecular heterogeneity. Somatic mutations in only three genes (TP53, PIK3CA and GATA3) occurred at >10% incidence across all breast cancers; however, there were numerous subtype-associated and novel gene mutations including the enrichment of specific mutations in GATA3, PIK3CA and MAP3K1 with the luminal A subtype. We identified two novel protein-expression-defined subgroups, possibly produced by stromal/microenvironmental elements, and integrated analyses identified specific signalling pathways dominant in each molecular subtype including a HER2/phosphorylated HER2/EGFR/phosphorylated EGFR signature within the HER2-enriched expression subtype. Comparison of basal-like breast tumours with high-grade serous ovarian tumours showed many molecular commonalities, indicating a related aetiology and similar therapeutic opportunities. The biological finding of the four main breast cancer subtypes caused by different subsets of genetic and epigenetic abnormalities raises the hypothesis that much of the clinically observable plasticity and heterogeneity occurs within, and not across, these major biological subtypes of breast cancer. more

Topics: Breast cancer (56%), Exome (54%), Claudin-Low (54%) more

8,025 Citations

Open accessJournal ArticleDOI: 10.1089/THY.2015.0020
01 Nov 2009-Thyroid
Abstract: Background: Thyroid nodules are a common clinical problem, and differentiated thyroid cancer is becoming increasingly prevalent. Since the American Thyroid Association's (ATA's) guidelines for the management of these disorders were revised in 2009, significant scientific advances have occurred in the field. The aim of these guidelines is to inform clinicians, patients, researchers, and health policy makers on published evidence relating to the diagnosis and management of thyroid nodules and differentiated thyroid cancer. Methods: The specific clinical questions addressed in these guidelines were based on prior versions of the guidelines, stakeholder input, and input of task force members. Task force panel members were educated on knowledge synthesis methods, including electronic database searching, review and selection of relevant citations, and critical appraisal of selected studies. Published English language articles on adults were eligible for inclusion. The American College of Physicians Guideline Gr... more

Topics: Thyroid neoplasm (73%), Thyroid nodules (72%), Thyroid cancer (69%) more

8,016 Citations

Open accessJournal ArticleDOI: 10.1038/NATURE07385
23 Oct 2008-Nature
Abstract: Human cancer cells typically harbour multiple chromosomal aberrations, nucleotide substitutions and epigenetic modifications that drive malignant transformation. The Cancer Genome Atlas ( TCGA) pilot project aims to assess the value of large- scale multi- dimensional analysis of these molecular characteristics in human cancer and to provide the data rapidly to the research community. Here we report the interim integrative analysis of DNA copy number, gene expression and DNA methylation aberrations in 206 glioblastomas - the most common type of primary adult brain cancer - and nucleotide sequence aberrations in 91 of the 206 glioblastomas. This analysis provides new insights into the roles of ERBB2, NF1 and TP53, uncovers frequent mutations of the phosphatidylinositol- 3- OH kinase regulatory subunit gene PIK3R1, and provides a network view of the pathways altered in the development of glioblastoma. Furthermore, integration of mutation, DNA methylation and clinical treatment data reveals a link between MGMT promoter methylation and a hypermutator phenotype consequent to mismatch repair deficiency in treated glioblastomas, an observation with potential clinical implications. Together, these findings establish the feasibility and power of TCGA, demonstrating that it can rapidly expand knowledge of the molecular basis of cancer. more

Topics: Oncogenomics (59%), DNA methylation (58%), Epigenetics (55%) more

6,131 Citations

No. of papers from the Institution in previous years

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Institution's top 5 most impactful journals


4.5K papers, 180K citations

Journal of Clinical Oncology

4.3K papers, 245.7K citations

Cancer Research

2.6K papers, 185.6K citations


2.5K papers, 181.8K citations

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