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Institution

University of Texas Medical Branch

EducationGalveston, Texas, United States
About: University of Texas Medical Branch is a education organization based out in Galveston, Texas, United States. It is known for research contribution in the topics: Population & Virus. The organization has 22033 authors who have published 38268 publications receiving 1517502 citations. The organization is also known as: The University of Texas Medical Branch at Galveston & UTMB.


Papers
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Journal ArticleDOI
TL;DR: Findings indicate that in cells expressing functional Bcl2, the mechanism of death action for ceramide may involve, at least in part, a mitochondrial PP2A that dephosphorylates and inactivates B cl2.

356 citations

Journal ArticleDOI
TL;DR: It is found that AC lung allowed for better retention of cells with more differentiation of mESCs into epithelial and endothelial lineages and highlights the critical role played by matrix or scaffold-associated cues in guiding ESC differentiation toward lung-specific lineages.
Abstract: We report here the first attempt to produce and use whole acellular (AC) lung as a matrix to support development of engineered lung tissue from murine embryonic stem cells (mESCs). We compared the influence of AC lung, Gelfoam, Matrigel, and a collagen I hydrogel matrix on the mESC attachment, differentiation, and subsequent formation of complex tissue. We found that AC lung allowed for better retention of cells with more differentiation of mESCs into epithelial and endothelial lineages. In constructs produced on whole AC lung, we saw indications of organization of differentiating ESC into three-dimensional structures reminiscent of complex tissues. We also saw expression of thyroid transcription factor-1, an immature lung epithelial cell marker; pro-surfactant protein C, a type II pneumocyte marker; PECAM-1/CD31, an endothelial cell marker; cytokeratin 18; alpha-actin, a smooth muscle marker; CD140a or platelet-derived growth factor receptor-alpha; and Clara cell protein 10. There was also evidence of site-specific differentiation in the trachea with the formation of sheets of cytokeratin-positive cells and Clara cell protein 10-expressing Clara cells. Our findings support the utility of AC lung as a matrix for engineering lung tissue and highlight the critical role played by matrix or scaffold-associated cues in guiding ESC differentiation toward lung-specific lineages.

356 citations

Journal ArticleDOI
TL;DR: On September 16, 2012, the National Lipid Association held a Consensus Conference with the goal of better defining the effect of adiposity on lipoproteins, how the pathos of excessive body fat (adiposopathy) contributes to dyslipidemia, and how therapies such as appropriate nutrition, increased physical activity, weight-management drugs, and bariatric surgery might be expected to impact dys Lipidemia.

356 citations

Journal ArticleDOI
TL;DR: Vitamin C and E supplementation initiated in the 9th to 16th week of pregnancy in an unselected cohort of low-risk, nulliparous women did not reduce the rate of adverse maternal or perinatal outcomes related to pregnancy-associated hypertension.
Abstract: Background Oxidative stress has been proposed as a mechanism linking the poor placental perfusion characteristic of preeclampsia with the clinical manifestations of the disorder. We assessed the effects of antioxidant supplementation with vitamins C and E, initiated early in pregnancy, on the risk of serious adverse maternal, fetal, and neonatal outcomes related to pregnancy-associated hypertension. Methods We conducted a multicenter, randomized, double-blind trial involving nulliparous women who were at low risk for preeclampsia. Women were randomly assigned to begin daily supplementation with 1000 mg of vitamin C and 400 IU of vitamin E or matching placebo between the 9th and 16th weeks of pregnancy. The primary outcome was severe pregnancy-associated hypertension alone or severe or mild hypertension with elevated liver-enzyme levels, thrombocytopenia, elevated serum creatinine levels, eclamptic seizure, medically indicated preterm birth, fetal-growth restriction, or perinatal death. Results A total of ...

356 citations

Journal ArticleDOI
TL;DR: An angiographically demonstrated and pathologically proved case of a venous angioma is reported and the differential diagnosis includes telangiectasia, infiltrating glioma, and probably a cavernousAngiomatous lesions at autopsy.
Abstract: • Only a few cases of angiographically demonstrated and pathologically proved cases of venous angiomas have been published. In contrast to the scarcity of recorded cases of angiographically studied venous angiomas, they are the most common incidentally encountered angiomatous lesions at autopsy. Their angiographic characterization, though highly suggestive, is not pathognomonic. The angiographic characteristics include small radiating veins that drain into a larger transcerebral vein that in turn empties into a dural sinus; blush and early draining veins also may be seen. The differential diagnosis includes telangiectasia, infiltrating glioma, and probably a cavernous angioma. We report an angiographically demonstrated and pathologically proved case of a venous angioma and also review the literature.

356 citations


Authors

Showing all 22143 results

NameH-indexPapersCitations
Stuart H. Orkin186715112182
Eric R. Kandel184603113560
John C. Morris1831441168413
Joseph Biederman1791012117440
Richard A. Gibbs172889249708
Timothy A. Springer167669122421
Gabriel N. Hortobagyi1661374104845
Roberto Romero1511516108321
Charles B. Nemeroff14997990426
Peter J. Schwartz147647107695
Clifford J. Woolf14150986164
Thomas J. Smith1401775113919
Edward C. Holmes13882485748
Jun Lu135152699767
Henry T. Lynch13392586270
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Performance
Metrics
No. of papers from the Institution in previous years
YearPapers
202330
2022196
20211,616
20201,487
20191,298
20181,152