Showing papers by "University of the Witwatersrand published in 2016"
TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
5,050 citations
TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
4,804 citations
TL;DR: In this article, the authors used a Bayesian hierarchical model to estimate trends in diabetes prevalence, defined as fasting plasma glucose of 7.0 mmol/L or higher, or history of diagnosis with diabetes, or use of insulin or oral hypoglycaemic drugs in 200 countries and territories in 21 regions, by sex and from 1980 to 2014.
2,782 citations
Nicholas J Kassebaum1, Megha Arora1, Ryan M Barber1, Zulfiqar A Bhutta2 +679 more•Institutions (268)
TL;DR: In this paper, the authors used the Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2015.
1,533 citations
TL;DR: The marketing of breastmilk substitutes negatively affects breastfeeding: global sales in 2014 of US$44·8 billion show the industry's large, competitive claim on infant feeding as discussed by the authors.
1,380 citations
TL;DR: The core CSF biomarkers of neurodegeneration (T-tau, P-tAU, and Aβ42), CSF NFL, and plasma T-t Tau were strongly associated with Alzheimer's disease and the core biomarkers were strong associated with mild cognitive impairment due to Alzheimer's Disease.
Abstract: Summary Background Alzheimer's disease biomarkers are important for early diagnosis in routine clinical practice and research. Three core CSF biomarkers for the diagnosis of Alzheimer's disease (Aβ42, T-tau, and P-tau) have been assessed in numerous studies, and several other Alzheimer's disease markers are emerging in the literature. However, there have been no comprehensive meta-analyses of their diagnostic performance. We systematically reviewed the literature for 15 biomarkers in both CSF and blood to assess which of these were most altered in Alzheimer's disease. Methods In this systematic review and meta-analysis, we screened PubMed and Web of Science for articles published between July 1, 1984, and June 30, 2014, about CSF and blood biomarkers reflecting neurodegeneration (T-tau, NFL, NSE, VLP-1, and HFABP), APP metabolism (Aβ42, Aβ40, Aβ38, sAPPα, and sAPPβ), tangle pathology (P-tau), blood–brain-barrier function (albumin ratio), and glial activation (YKL-40, MCP-1, and GFAP). Data were taken from cross-sectional cohort studies as well as from baseline measurements in longitudinal studies with clinical follow-up. Articles were excluded if they did not contain a cohort with Alzheimer's disease and a control cohort, or a cohort with mild cognitive impairment due to Alzheimer's disease and a stable mild cognitive impairment cohort. Data were extracted by ten authors and checked by two for accuracy. For quality assessment, modified QUADAS criteria were used. Biomarker performance was rated by random-effects meta-analysis based on the ratio between biomarker concentration in patients with Alzheimer's disease and controls (fold change) or the ratio between biomarker concentration in those with mild cognitive impariment due to Alzheimer's disease and those with stable mild cognitive impairment who had a follow-up time of at least 2 years and no further cognitive decline. Findings Of 4521 records identified from PubMed and 624 from Web of Science, 231 articles comprising 15 699 patients with Alzheimer's disease and 13 018 controls were included in this analysis. The core biomarkers differentiated Alzheimer's disease from controls with good performance: CSF T-tau (average ratio 2·54, 95% CI 2·44–2·64, p Interpretation The core CSF biomarkers of neurodegeneration (T-tau, P-tau, and Aβ42), CSF NFL, and plasma T-tau were strongly associated with Alzheimer's disease and the core biomarkers were strongly associated with mild cognitive impairment due to Alzheimer's disease. Emerging CSF biomarkers NSE, VLP-1, HFABP, and YKL-40 were moderately associated with Alzheimer's disease, whereas plasma Aβ42 and Aβ40 were not. Due to their consistency, T-tau, P-tau, Aβ42, and NFL in CSF should be used in clinical practice and clinical research. Funding Swedish Research Council, Swedish State Support for Clinical Research, Alzheimer's Association, Knut and Alice Wallenberg Foundation, Torsten Soderberg Foundation, Alzheimer Foundation (Sweden), European Research Council, and Biomedical Research Forum.
1,350 citations
James Bentham1, Mariachiara Di Cesare2, Mariachiara Di Cesare1, Gretchen A Stevens3 +787 more•Institutions (246)
TL;DR: The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
Abstract: Being taller is associated with enhanced longevity, and higher education and earnings. We reanalysed 1472 population-based studies, with measurement of height on more than 18.6 million participants to estimate mean height for people born between 1896 and 1996 in 200 countries. The largest gain in adult height over the past century has occurred in South Korean women and Iranian men, who became 20.2 cm (95% credible interval 17.5–22.7) and 16.5 cm (13.3–19.7) taller, respectively. In contrast, there was little change in adult height in some sub-Saharan African countries and in South Asia over the century of analysis. The tallest people over these 100 years are men born in the Netherlands in the last quarter of 20th century, whose average heights surpassed 182.5 cm, and the shortest were women born in Guatemala in 1896 (140.3 cm; 135.8–144.8). The height differential between the tallest and shortest populations was 19-20 cm a century ago, and has remained the same for women and increased for men a century later despite substantial changes in the ranking of countries.
1,348 citations
Aarhus University1, Washington University in St. Louis2, University of the Witwatersrand3, University of Oxford4, Sapienza University of Rome5, Harvard University6, Karolinska Institutet7, Walton Centre8, Johns Hopkins University9, Imperial College London10, Chelsea and Westminster Hospital NHS Foundation Trust11, University of Dundee12, Heidelberg University13
TL;DR: A revised grading system of possible, probable, and definite neuropathic pain from 2008 is presented with an adjusted order, better reflecting clinical practice, improvements in the specifications, and a word of caution that even the “definite” level of neuropathicPain does not always indicate causality.
Abstract: The redefinition of neuropathic pain as "pain arising as a direct consequence of a lesion or disease affecting the somatosensory system," which was suggested by the International Association for the Study of Pain (IASP) Special Interest Group on Neuropathic Pain (NeuPSIG) in 2008, has been widely accepted. In contrast, the proposed grading system of possible, probable, and definite neuropathic pain from 2008 has been used to a lesser extent. Here, we report a citation analysis of the original NeuPSIG grading paper of 2008, followed by an analysis of its use by an expert panel and recommendations for an improved grading system. As of February, 2015, 608 eligible articles in Scopus cited the paper, 414 of which cited the neuropathic pain definition. Of 220 clinical studies citing the paper, 56 had used the grading system. The percentage using the grading system increased from 5% in 2009 to 30% in 2014. Obstacles to a wider use of the grading system were identified, including (1) questions about the relative significance of confirmatory tests, (2) the role of screening tools, and (3) uncertainties about what is considered a neuroanatomically plausible pain distribution. Here, we present a revised grading system with an adjusted order, better reflecting clinical practice, improvements in the specifications, and a word of caution that even the "definite" level of neuropathic pain does not always indicate causality. In addition, we add a table illustrating the area of pain and sensory abnormalities in common neuropathic pain conditions and propose areas for further research.
745 citations
Nicholas J Kassebaum1, Ryan M Barber1, Zulfiqar A Bhutta2, Zulfiqar A Bhutta3 +613 more•Institutions (272)
TL;DR: In this article, the authors quantified maternal mortality throughout the world by underlying cause and age from 1990 to 2015 for ages 10-54 years by systematically compiling and processing all available data sources from 186 of 195 countries and territories.
641 citations
Haidong Wang1, Zulfiqar A Bhutta2, Zulfiqar A Bhutta3, Matthew M Coates1 +610 more•Institutions (263)
TL;DR: The Global Burden of Disease 2015 Study provides an analytical framework to comprehensively assess trends for under-5 mortality, age-specific and cause-specific mortality among children under 5 years, and stillbirths by geography over time and decomposed the changes in under- 5 mortality to changes in SDI at the global level.
591 citations
TL;DR: This report provides national estimates of levels and trends of HIV/AIDS incidence, prevalence, coverage of antiretroviral therapy (ART), and mortality for 195 countries and territories from 1980 to 2015.
TL;DR: In this paper, the limits placed on the "decolonization" project by the forces of neoliberalism are discussed, and how the latter affects the future of the university and its future of education.
Abstract: What are the limits placed on the ‘decolonization’ project by the forces of neoliberalism? How are the latter affecting the future of the university? Is ‘decolonization’ the same as ‘Africanization’?
TL;DR: It is outlined how virtually all the previous ISO-standard beam diagnostic techniques may be readily replaced with all-digital equivalents, thus paving the way for unravelling of light in real time.
Abstract: Modal decomposition of light has been known for a long time, applied mostly to pattern recognition. With the commercialization of liquid-crystal devices, digital holography as an enabling tool has become accessible to all, and with it all-digital tools for the decomposition of light have finally come of age. We review recent advances in unravelling the properties of light, from the modal structure of laser beams to decoding the information stored in orbital angular momentum (OAM)-carrying fields. We show application of these tools to fiber lasers, solid-state lasers, and structured light created in the laboratory by holographic laser beam shaping. We show by experimental implementation how digital holograms may be used to infer the intensity, phase, wavefront, Poynting vector, polarization, and OAM density of some unknown optical field. In particular, we outline how virtually all the previous ISO-standard beam diagnostic techniques may be readily replaced with all-digital equivalents, thus paving the way for unravelling of light in real time. Such tools are highly relevant to the in situ analysis of laser systems, to mode division multiplexing as an emerging tool in optical communication, and for quantum information processing with entangled photons.
University of Washington1, University of the Witwatersrand2, Fred Hutchinson Cancer Research Center3, FHI 3604, National Institutes of Health5, South African Medical Research Council6, University of Zimbabwe7, Makerere University8, Centre for the AIDS Programme of Research in South Africa9, University of Cape Town10, University of Pittsburgh11, Johns Hopkins University12, University of California, San Francisco13, RTI International14, Population Council15
TL;DR: A monthly vaginal ring containing dapivirine reduced the risk of HIV-1 infection among African women, with increased efficacy in subgroups with evidence of increased adherence.
Abstract: (ed from N Engl J Med 2016; DOI: 10.1056/NEJMoa1506110)The objective of this study was to examine the efficacy of dapivirine vaginal rings in providing protection against human immunodeficiency virus type 1 (HIV-1). HIV-1 infection incidence is one of the highest in sub-Saharan Africa.
Children's Medical Research Institute1, University of Birmingham2, University College Cork3, South Dakota State University4, Mayo Clinic5, Osaka University6, Rambam Health Care Campus7, University of Manchester8, University of the Philippines Manila9, University of Zurich10, University of the Witwatersrand11, Boston Children's Hospital12, Ahmadu Bello University13, Sanjay Gandhi Post Graduate Institute of Medical Sciences14, Zhejiang University15, Medical Research Council16, Karolinska Institutet17, All India Institute of Medical Sciences18, University College London19, University of Lagos20
TL;DR: Rickets, osteomalacia, and vitamin D and calcium deficiencies are preventable global public health problems in infants, children, and adolescents and implementation of international rickets prevention programs, including supplementation and food fortification is urgently required.
Abstract: Background: Vitamin D and calcium deficiencies are common worldwide, causing nutritional rickets and osteomalacia, which have a major impact on health, growth, an
TL;DR: In this paper, the angular momentum of light can be described by positions on a higher-order Poincare sphere, where superpositions of spin and orbital angular momentum states give rise to laser beams that have many applications.
Abstract: The angular momentum of light can be described by positions on a higher-order Poincare sphere, where superpositions of spin and orbital angular momentum states give rise to laser beams that have many applications, from microscopy to materials processing. Many techniques exist to create such beams but none so far allow their creation at the source. Here we report on a new class of laser that is able to generate all states on the higher-order Poincare sphere. We exploit geometric phase control inside a laser cavity to map polarization to orbital angular momentum, demonstrating that the orbital angular momentum degeneracy of a standard laser cavity may be broken, producing pure orbital angular momentum beams, and that generalized vector vortex beams may be created with high purity at the source. This work paves the way to new lasers for structured light based on intracavity geometric phase control. By exploiting geometric phase control inside a laser cavity to map polarization to orbital angular momentum, a new class of laser that is able to generate all states on the higher-order Poincare sphere is reported.
TL;DR: Global research efforts are needed to establish preventive strategies and treatments for the various types of pulmonary hypertension, where pulmonary hypertension is frequently associated with congenital heart disease and various infectious disorders, including schistosomiasis, HIV, and rheumatic heart disease.
TL;DR: In this article, the performance of the ATLAS muon identification and reconstruction using the first LHC dataset recorded at s√ = 13 TeV in 2015 was evaluated using the Monte Carlo simulations.
Abstract: This article documents the performance of the ATLAS muon identification and reconstruction using the first LHC dataset recorded at s√ = 13 TeV in 2015. Using a large sample of J/ψ→μμ and Z→μμ decays from 3.2 fb−1 of pp collision data, measurements of the reconstruction efficiency, as well as of the momentum scale and resolution, are presented and compared to Monte Carlo simulations. The reconstruction efficiency is measured to be close to 99% over most of the covered phase space (|η| 2.2, the pT resolution for muons from Z→μμ decays is 2.9% while the precision of the momentum scale for low-pT muons from J/ψ→μμ decays is about 0.2%.
A. Abramowski1, Felix Aharonian2, Faical Ait Benkhali2, A. G. Akhperjanian +226 more•Institutions (28)
TL;DR: Deep γ-ray observations with arcminute angular resolution of the region surrounding the Galactic Centre are reported, which show the expected tracer of the presence of petaelectronvolt protons within the central 10 parsecs of the Galaxy, and it is proposed that the supermassive black hole Sagittarius A* is linked to this PeVatron.
Abstract: Galactic cosmic rays reach energies of at least a few petaelectronvolts(1) (of the order of 1015 electronvolts). This implies that our Galaxy contains petaelectronvolt accelerators ('PeVatrons'), b ...
University of Milan1, Cairo University2, Jehangir Hospital3, Shahid Beheshti University of Medical Sciences and Health Services4, Shiraz University of Medical Sciences5, St. John's Medical College6, University of Southern California7, All India Institute of Medical Sciences8, Mexican Social Security Institute9, University of the Witwatersrand10, Medical University of Vienna11, City of Hope National Medical Center12, Alfaisal University13, Rush University Medical Center14, University of Mississippi15, Çukurova University16, Ege University17, University of Colorado Denver18, Ain Shams University19, Sapienza University of Rome20, Johannes Kepler University of Linz21, Children's Mercy Hospital22, Istanbul University23, Leiden University24
TL;DR: Patients treated with plasma-derived factor VIII containing von Willebrand factor had a lower incidence of inhibitors than those treated with recombinant factor VIII, and this association did not change in multivariable analysis.
Abstract: BackgroundThe development of neutralizing anti–factor VIII alloantibodies (inhibitors) in patients with severe hemophilia A may depend on the concentrate used for replacement therapy. MethodsWe conducted a randomized trial to assess the incidence of factor VIII inhibitors among patients treated with plasma-derived factor VIII containing von Willebrand factor or recombinant factor VIII. Patients who met the eligibility criteria (male sex, age <6 years, severe hemophilia A, and no previous treatment with any factor VIII concentrate or only minimal treatment with blood components) were included from 42 sites. ResultsOf 303 patients screened, 264 underwent randomization and 251 were analyzed. Inhibitors developed in 76 patients, 50 of whom had high-titer inhibitors (≥5 Bethesda units). Inhibitors developed in 29 of the 125 patients treated with plasma-derived factor VIII (20 patients had high-titer inhibitors) and in 47 of the 126 patients treated with recombinant factor VIII (30 patients had high-titer inhib...
TL;DR: The number of children exposed to stunting or poverty between 2004 and 2010 decreased and prevalence of children at risk fell from 51% (95% CI 46–56) to 43% (36–51); the decline occurred in all income groups and regions with south Asia experiencing the largest drop.
TL;DR: In this paper, an independent b-tagging algorithm based on the reconstruction of muons inside jets as well as the b tagging algorithm used in the online trigger are also presented.
Abstract: The identification of jets containing b hadrons is important for the physics programme of the ATLAS experiment at the Large Hadron Collider. Several algorithms to identify jets containing b hadrons are described, ranging from those based on the reconstruction of an inclusive secondary vertex or the presence of tracks with large impact parameters to combined tagging algorithms making use of multi-variate discriminants. An independent b-tagging algorithm based on the reconstruction of muons inside jets as well as the b-tagging algorithm used in the online trigger are also presented. The b-jet tagging efficiency, the c-jet tagging efficiency and the mistag rate for light flavour jets in data have been measured with a number of complementary methods. The calibration results are presented as scale factors defined as the ratio of the efficiency (or mistag rate) in data to that in simulation. In the case of b jets, where more than one calibration method exists, the results from the various analyses have been combined taking into account the statistical correlation as well as the correlation of the sources of systematic uncertainty.
Liverpool School of Tropical Medicine1, Bill & Melinda Gates Foundation2, The Global Fund to Fight AIDS, Tuberculosis and Malaria3, Centers for Disease Control and Prevention4, University of the Witwatersrand5, Institut de recherche pour le développement6, Rothamsted Research7, University of Oxford8, University of London9
TL;DR: To combat the threat of resistance, key stakeholders need to rapidly embrace a multifaceted approach including a reduction in the cost of bringing new resistance management methods to market and the streamlining of associated development, policy, and implementation pathways to counter this looming public health catastrophe.
TL;DR: The proposed framework has the potential to provide options when faced with complex concepts or broad research questions and recommends including both quantitative and qualitative research, as well as evidence from economic and expert opinion sources to answer questions of effectiveness, appropriateness, meaningfulness and feasibility of health practices and delivery methods.
Abstract: Objective
Scoping reviews are used to assess the extent of a body of literature on a particular topic, and often to ensure that further research in that area is a beneficial addition to world knowledge. The aim of this paper reports upon the development of a methodology for scoping reviews based upon the Arksey and O'Malley framework, the Levac, Colquhoun, and O'Brien, and the Joanna Briggs Institute methods of evidence synthesis.
Methods
A working group consisting of members of the Joanna Briggs collaborating organizations met to discuss the proposed framework for the methodology and develop a draft for the scoping review methodology based on the Arksey and O'Malley framework and the work of Levac et al. This was followed by a workshop attended by other members of the organizations consisting of 30 international researchers to discuss the proposed methodology. Further refinement of the methodology was undertaken as a result of the feedback received from the workshop.
Results
The development of the methodology focused on five stages of the protocol and review development. These were identifying the research question by clarifying and linking the purpose and research question, identifying the relevant studies using a three-step literature search in order to balance feasibility with breadth and comprehensiveness, careful selection of the studies to using a team approach, charting the data and collating the results to identify the implications of the study findings for policy, practice, or research.
Linking Evidence to Action
The current methodology recommends including both quantitative and qualitative research, as well as evidence from economic and expert opinion sources to answer questions of effectiveness, appropriateness, meaningfulness and feasibility of health practices and delivery methods. The proposed framework has the potential to provide options when faced with complex concepts or broad research questions.
TL;DR: The methods employed in the ATLAS experiment to correct for the impact of pile-up on jet energy and jet shapes, and for the presence of spurious additional jets, are described, with a primary focus on the large 20.3 kg-1 data sample.
Abstract: The large rate of multiple simultaneous protonproton interactions, or pile-up, generated by the Large Hadron Collider in Run 1 required the development of many new techniques to mitigate the advers ...
TL;DR: It is possible to combine ultrasound, microbubbles, and chemotherapy in a clinical setting using commercially available equipment with no additional toxicities and this combined treatment may improve the clinical efficacy of gemcitabine, prolong the quality of life, and extend survival in patients with pancreatic ductal adenocarcinoma.
University of São Paulo1, Alfred I. duPont Hospital for Children2, Robarts Research Institute3, University of Pennsylvania4, University of New South Wales5, University of Western Australia6, Boca Raton Regional Hospital7, University of Milan8, University of Amsterdam9, Masaryk University10, McGill University11, University College London12, University of Kansas13, University of the Witwatersrand14, Sultan Qaboos University15, Imperial College London16, Erasmus University Rotterdam17, Osaka University18
TL;DR: This Review aims to define a phenotype for severe familial hypercholesterolaemia and identify people at highest risk for cardiovascular disease, based on the concentration of LDL cholesterol in blood and individuals' responsiveness to conventional lipid-lowering treatment.
TL;DR: This paper conducted a meta-analysis of 738 correspondence tests in 43 separate studies conducted in OECD countries between 1990 and 2015, focusing on groups of specific tests to ascertain the robustness of the results.
Abstract: For almost 50 years field experiments have been used to study ethnic and racial discrimination in hiring decisions, consistently reporting high rates of discrimination against minority applicants – including immigrants – irrespective of time, location, or minority groups tested. While Peter A. Riach and Judith Rich [2002. “Field Experiments of Discrimination in the Market Place.” The Economic Journal 112 (483): F480–F518] and Judith Rich [2014. “What Do Field Experiments of Discrimination in Markets Tell Us? A Meta Analysis of Studies Conducted since 2000.” In Discussion Paper Series. Bonn: IZA] provide systematic reviews of existing field experiments, no study has undertaken a meta-analysis to examine the findings in the studies reported. In this article, we present a meta-analysis of 738 correspondence tests in 43 separate studies conducted in OECD countries between 1990 and 2015. In addition to summarising research findings, we focus on groups of specific tests to ascertain the robustness of fi...
University of Basel1, Swiss Tropical and Public Health Institute2, Tunis University3, Fudan University4, University of Bern5, Sichuan University6, University of California, San Francisco7, Ifakara Health Institute8, University of Ghana9, Makerere University10, University of Amsterdam11, Case Western Reserve University12, Auckland City Hospital13, RMIT University14, University of Cape Town15, Francis Crick Institute16, Imperial College London17, Papua New Guinea Institute of Medical Research18, Institute of Tropical Medicine Antwerp19, Tartu University Hospital20, University of Tübingen21, University of Yaoundé I22, University of Arkansas for Medical Sciences23, Jomo Kenyatta University of Agriculture and Technology24, Aga Khan University Hospital25, Medical Research Council26, University of the Witwatersrand27, National Institute for Medical Research28, Ludwig Maximilian University of Munich29, Public Health Agency of Sweden30, Vilnius University31, Instituto de Medicina Tropical Alexander von Humboldt32, Moi University33, Brown University34, Pasteur Institute35, Spanish National Research Council36
TL;DR: It is shown that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists, and further support a European origin for the most common generalist sublineage.
Abstract: Generalist and specialist species differ in the breadth of their ecological niches Little is known about the niche width of obligate human pathogens Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists Our data further support a European origin for the most common generalist sublineage Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration
TL;DR: The luminosity determination for the ATLAS detector at the LHC during pp collisions at s√= 8 TeV in 2012 is presented in this article, where the evaluation of the luminosity scale is performed using several luminometers.
Abstract: The luminosity determination for the ATLAS detector at the LHC during pp collisions at s√= 8 TeV in 2012 is presented. The evaluation of the luminosity scale is performed using several luminometers ...