Institution
University of the Witwatersrand
Education•Johannesburg, South Africa•
About: University of the Witwatersrand is a education organization based out in Johannesburg, South Africa. It is known for research contribution in the topics: Population & Context (language use). The organization has 25215 authors who have published 52766 publications receiving 1347668 citations. The organization is also known as: Wits University & University of Witwatersrand.
Topics: Population, Context (language use), Health care, Acquired immunodeficiency syndrome (AIDS), Public health
Papers published on a yearly basis
Papers
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TL;DR: The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 (GBD 2015) as discussed by the authors was used to estimate the incidence, prevalence, and years lived with disability for diseases and injuries at the global, regional, and national scale over the period of 1990 to 2015.
5,050 citations
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TL;DR: The Global Burden of Disease 2015 Study provides a comprehensive assessment of all-cause and cause-specific mortality for 249 causes in 195 countries and territories from 1980 to 2015, finding several countries in sub-Saharan Africa had very large gains in life expectancy, rebounding from an era of exceedingly high loss of life due to HIV/AIDS.
4,804 citations
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University of Alabama at Birmingham1, University of Wisconsin-Madison2, Autonomous University of Barcelona3, Eli Lilly and Company4, University of Texas MD Anderson Cancer Center5, University of Virginia6, University of the Witwatersrand7, University of Colorado Boulder8, Gdańsk Medical University9, University of Alabama10, Merck KGaA11, ImClone Systems12
TL;DR: Treatment of locoregionally advanced head and neck cancer with concomitant high-dose radiotherapy plus cetuximab improves locoreGional control and reduces mortality without increasing the common toxic effects associated with radiotherapy to the head andneck.
Abstract: BACKGROUND We conducted a multinational, randomized study to compare radiotherapy alone with radiotherapy plus cetuximab, a monoclonal antibody against the epidermal growth factor receptor, in the treatment of locoregionally advanced squamous-cell carcinoma of the head and neck. METHODS Patients with locoregionally advanced head and neck cancer were randomly assigned to treatment with high-dose radiotherapy alone (213 patients) or high-dose radiotherapy plus weekly cetuximab (211 patients) at an initial dose of 400 mg per square meter of body-surface area, followed by 250 mg per square meter weekly for the duration of radiotherapy. The primary end point was the duration of control of locoregional disease; secondary end points were overall survival, progression-free survival, the response rate, and safety. RESULTS The median duration of locoregional control was 24.4 months among patients treated with cetuximab plus radiotherapy and 14.9 months among those given radiotherapy alone (hazard ratio for locoregional progression or death, 0.68; P = 0.005). With a median follow-up of 54.0 months, the median duration of overall survival was 49.0 months among patients treated with combined therapy and 29.3 months among those treated with radiotherapy alone (hazard ratio for death, 0.74; P = 0.03). Radiotherapy plus cetuximab significantly prolonged progression-free survival (hazard ratio for disease progression or death, 0.70; P = 0.006). With the exception of acneiform rash and infusion reactions, the incidence of grade 3 or greater toxic effects, including mucositis, did not differ significantly between the two groups. CONCLUSIONS Treatment of locoregionally advanced head and neck cancer with concomitant highdose radiotherapy plus cetuximab improves locoregional control and reduces mortality without increasing the common toxic effects associated with radiotherapy to the head and neck. (ClinicalTrials.gov number, NCT00004227.)
4,705 citations
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TL;DR: In the Global Burden of Disease Study 2013 (GBD 2013) as mentioned in this paper, the authors estimated the quantities for acute and chronic diseases and injuries for 188 countries between 1990 and 2013.
4,510 citations
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Katholieke Universiteit Leuven1, Ghent University2, Karolinska Institutet3, Cairo University4, University of São Paulo5, Cincinnati Children's Hospital Medical Center6, Innsbruck Medical University7, University of Duisburg-Essen8, Tufts University9, University of Aberdeen10, University of California, San Diego11, University College Dublin12, University of the Witwatersrand13, Brown University14, Heidelberg University15, Jikei University School of Medicine16
4,482 citations
Authors
Showing all 25515 results
Name | H-index | Papers | Citations |
---|---|---|---|
Charles A. Dinarello | 190 | 1058 | 139668 |
Andrew D. Hamilton | 151 | 1334 | 105439 |
Nilesh J. Samani | 149 | 779 | 113545 |
Christopher Hill | 144 | 1562 | 128098 |
Clifford J. Woolf | 141 | 509 | 86164 |
Xin Chen | 139 | 1008 | 113088 |
Robert Huber | 139 | 671 | 73557 |
Sinead Farrington | 133 | 1422 | 91099 |
Henry Lubatti | 130 | 1214 | 87247 |
Deepak Kar | 128 | 1053 | 75598 |
Mauro Villa | 128 | 1044 | 76521 |
Trevor Vickey | 128 | 873 | 76664 |
Fred Wickens | 127 | 902 | 75018 |
J. D. Hansen | 122 | 975 | 76198 |
Lisa F. Berkman | 120 | 411 | 67397 |