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Showing papers by "University of Tokyo published in 2010"


Journal ArticleDOI
26 Mar 2010-Science
TL;DR: Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated with elastomeric substrates, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments, and applications in systems ranging from electronic eyeball cameras to deformable light-emitting displays are described.
Abstract: Recent advances in mechanics and materials provide routes to integrated circuits that can offer the electrical properties of conventional, rigid wafer-based technologies but with the ability to be stretched, compressed, twisted, bent, and deformed into arbitrary shapes. Inorganic and organic electronic materials in microstructured and nanostructured forms, intimately integrated with elastomeric substrates, offer particularly attractive characteristics, with realistic pathways to sophisticated embodiments. Here, we review these strategies and describe applications of them in systems ranging from electronic eyeball cameras to deformable light-emitting displays. We conclude with some perspectives on routes to commercialization, new device opportunities, and remaining challenges for research.

4,127 citations


Proceedings ArticleDOI
26 Apr 2010
TL;DR: This paper investigates the real-time interaction of events such as earthquakes in Twitter and proposes an algorithm to monitor tweets and to detect a target event and produces a probabilistic spatiotemporal model for the target event that can find the center and the trajectory of the event location.
Abstract: Twitter, a popular microblogging service, has received much attention recently. An important characteristic of Twitter is its real-time nature. For example, when an earthquake occurs, people make many Twitter posts (tweets) related to the earthquake, which enables detection of earthquake occurrence promptly, simply by observing the tweets. As described in this paper, we investigate the real-time interaction of events such as earthquakes in Twitter and propose an algorithm to monitor tweets and to detect a target event. To detect a target event, we devise a classifier of tweets based on features such as the keywords in a tweet, the number of words, and their context. Subsequently, we produce a probabilistic spatiotemporal model for the target event that can find the center and the trajectory of the event location. We consider each Twitter user as a sensor and apply Kalman filtering and particle filtering, which are widely used for location estimation in ubiquitous/pervasive computing. The particle filter works better than other comparable methods for estimating the centers of earthquakes and the trajectories of typhoons. As an application, we construct an earthquake reporting system in Japan. Because of the numerous earthquakes and the large number of Twitter users throughout the country, we can detect an earthquake with high probability (96% of earthquakes of Japan Meteorological Agency (JMA) seismic intensity scale 3 or more are detected) merely by monitoring tweets. Our system detects earthquakes promptly and sends e-mails to registered users. Notification is delivered much faster than the announcements that are broadcast by the JMA.

3,976 citations


Journal ArticleDOI
TL;DR: In this paper, a review of experimental and theoretical studies of anomalous Hall effect (AHE), focusing on recent developments that have provided a more complete framework for understanding this subtle phenomenon and have, in many instances, replaced controversy by clarity.
Abstract: We present a review of experimental and theoretical studies of the anomalous Hall effect (AHE), focusing on recent developments that have provided a more complete framework for understanding this subtle phenomenon and have, in many instances, replaced controversy by clarity. Synergy between experimental and theoretical work, both playing a crucial role, has been at the heart of these advances. On the theoretical front, the adoption of Berry-phase concepts has established a link between the AHE and the topological nature of the Hall currents which originate from spin-orbit coupling. On the experimental front, new experimental studies of the AHE in transition metals, transition-metal oxides, spinels, pyrochlores, and metallic dilute magnetic semiconductors, have more clearly established systematic trends. These two developments in concert with first-principles electronic structure calculations, strongly favor the dominance of an intrinsic Berry-phase-related AHE mechanism in metallic ferromagnets with moderate conductivity. The intrinsic AHE can be expressed in terms of Berry-phase curvatures and it is therefore an intrinsic quantum mechanical property of a perfect cyrstal. An extrinsic mechanism, skew scattering from disorder, tends to dominate the AHE in highly conductive ferromagnets. We review the full modern semiclassical treatment of the AHE together with the more rigorous quantum-mechanical treatments based on the Kubo and Keldysh formalisms, taking into account multiband effects, and demonstrate the equivalence of all three linear response theories in the metallic regime. Finally we discuss outstanding issues and avenues for future investigation.

2,970 citations


Journal ArticleDOI
TL;DR: Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.
Abstract: Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are suitable for studying drug interactions with these transporters. In addition, what criteria should trigger follow-up clinical studies, and which clinical studies should be conducted if needed. In this article, we provide the recommendations of the International Transporter Consortium on these issues, and present decision trees that are intended to help guide clinical studies on the currently recognized most important drug transporter interactions. The recommendations are generally intended to support clinical development and filing of a new drug application. Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions (for example, exclusion and inclusion criteria), as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.

2,879 citations


Journal ArticleDOI
Koji Nakamura1, K. Hagiwara, Ken Ichi Hikasa2, Hitoshi Murayama3  +180 moreInstitutions (92)
TL;DR: In this article, a biennial review summarizes much of particle physics using data from previous editions, plus 2158 new measurements from 551 papers, they list, evaluate and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons.
Abstract: This biennial Review summarizes much of particle physics. Using data from previous editions, plus 2158 new measurements from 551 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons. We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles. All the particle properties and search limits are listed in Summary Tables. We also give numerous tables, figures, formulae, and reviews of topics such as the Standard Model, particle detectors, probability, and statistics. Among the 108 reviews are many that are new or heavily revised including those on neutrino mass, mixing, and oscillations, QCD, top quark, CKM quark-mixing matrix, V-ud & V-us, V-cb & V-ub, fragmentation functions, particle detectors for accelerator and non-accelerator physics, magnetic monopoles, cosmological parameters, and big bang cosmology.

2,788 citations


Journal ArticleDOI
17 Jun 2010-Nature
TL;DR: Real-space imaging of a two-dimensional skyrmion lattice in a thin film of Fe0.5Co 0.5Si using Lorentz transmission electron microscopy reveals a controlled nanometre-scale spin topology, which may be useful in observing unconventional magneto-transport effects.
Abstract: Crystal order is not restricted to the periodic atomic array, but can also be found in electronic systems such as the Wigner crystal or in the form of orbital order, stripe order and magnetic order. In the case of magnetic order, spins align parallel to each other in ferromagnets and antiparallel in antiferromagnets. In other, less conventional, cases, spins can sometimes form highly nontrivial structures called spin textures. Among them is the unusual, topologically stable skyrmion spin texture, in which the spins point in all the directions wrapping a sphere. The skyrmion configuration in a magnetic solid is anticipated to produce unconventional spin-electronic phenomena such as the topological Hall effect. The crystallization of skyrmions as driven by thermal fluctuations has recently been confirmed in a narrow region of the temperature/magnetic field (T-B) phase diagram in neutron scattering studies of the three-dimensional helical magnets MnSi (ref. 17) and Fe(1-x)Co(x)Si (ref. 22). Here we report real-space imaging of a two-dimensional skyrmion lattice in a thin film of Fe(0.5)Co(0.5)Si using Lorentz transmission electron microscopy. With a magnetic field of 50-70 mT applied normal to the film, we observe skyrmions in the form of a hexagonal arrangement of swirling spin textures, with a lattice spacing of 90 nm. The related T-B phase diagram is found to be in good agreement with Monte Carlo simulations. In this two-dimensional case, the skyrmion crystal seems very stable and appears over a wide range of the phase diagram, including near zero temperature. Such a controlled nanometre-scale spin topology in a thin film may be useful in observing unconventional magneto-transport effects.

2,683 citations


Journal ArticleDOI
TL;DR: In this article, the state of the art and future challenges in photocatalytic water splitting with a focus on the recent progress of our own research are discussed. But the focus is on the development of cocatalysts and related physical and materials chemistry.
Abstract: Water splitting to form hydrogen and oxygen using solar energy in the presence of semiconductor photocatalysts has long been studied as a potential means of clean, large-scale fuel production. In general, overall water splitting can be achieved when a photocatalyst is modified with a suitable cocatalyst. It is therefore important to develop both photocatalysts and cocatalysts. In the past five years, there has been significant progress in water splitting photocatalysis, especially in the development of cocatalysts and related physical and materials chemistry. This work describes the state of the art and future challenges in photocatalytic water splitting, with a focus on the recent progress of our own research.

2,203 citations


Journal ArticleDOI
TL;DR: The new disease/drug information resource named KEGG MEDICUS can be used as a reference knowledge base for computational analysis of molecular networks, especially, by integrating large-scale experimental datasets.
Abstract: Most human diseases are complex multi-factorial diseases resulting from the combination of various genetic and environmental factors. In the KEGG database resource (http://www.genome.jp/kegg/), diseases are viewed as perturbed states of the molecular system, and drugs as perturbants to the molecular system. Disease information is computerized in two forms: pathway maps and gene/ molecule lists. The KEGG PATHWAY database contains pathway maps for the molecular systems in both normal and perturbed states. In the KEGG DISEASE database, each disease is represented by a list of known disease genes, any known environmental factors at the molecular level, diagnostic markers and therapeutic drugs, which may reflect the underlying molecular system. The KEGG DRUG database contains chemical structures and/or chemical components of all drugs in Japan, including crude drugs and TCM (Traditional Chinese Medicine) formulas, and drugs in the USA and Europe. This database also captures knowledge about two types of molecular networks: the interaction network with target molecules, metabolizing enzymes, other drugs, etc. and the chemical structure transformation network in the history of drug development. The new disease/drug information resource named KEGG MEDICUS can be used as a reference knowledge base for computational analysis of molecular networks, especially, by integrating large-scale experimental datasets.

2,181 citations


Journal ArticleDOI
13 May 2010-Nature
TL;DR: It is revealed that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis, which occurs specifically at enhancers that are actively engaged in promoting mRNA synthesis.
Abstract: We used genome-wide sequencing methods to study stimulus-dependent enhancer function in mouse cortical neurons. We identified approximately 12,000 neuronal activity-regulated enhancers that are bound by the general transcriptional co-activator CBP in an activity-dependent manner. A function of CBP at enhancers may be to recruit RNA polymerase II (RNAPII), as we also observed activity-regulated RNAPII binding to thousands of enhancers. Notably, RNAPII at enhancers transcribes bi-directionally a novel class of enhancer RNAs (eRNAs) within enhancer domains defined by the presence of histone H3 monomethylated at lysine 4. The level of eRNA expression at neuronal enhancers positively correlates with the level of messenger RNA synthesis at nearby genes, suggesting that eRNA synthesis occurs specifically at enhancers that are actively engaged in promoting mRNA synthesis. These findings reveal that a widespread mechanism of enhancer activation involves RNAPII binding and eRNA synthesis.

2,177 citations


Journal ArticleDOI
Thomas J. Hudson1, Thomas J. Hudson2, Warwick Anderson3, Axel Aretz4  +270 moreInstitutions (92)
15 Apr 2010
TL;DR: Systematic studies of more than 25,000 cancer genomes will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.
Abstract: The International Cancer Genome Consortium (ICGC) was launched to coordinate large-scale cancer genome studies in tumours from 50 different cancer types and/or subtypes that are of clinical and societal importance across the globe. Systematic studies of more than 25,000 cancer genomes at the genomic, epigenomic and transcriptomic levels will reveal the repertoire of oncogenic mutations, uncover traces of the mutagenic influences, define clinically relevant subtypes for prognosis and therapeutic management, and enable the development of new cancer therapies.

2,041 citations



Journal ArticleDOI
TL;DR: In this paper, the authors examined joint associations of 12 childhood adversities with first onset of 20 DSM-IV disorders in World Mental Health Surveys in 21 countries and found strong associations with all classes of disorders at all life-course stages.
Abstract: Background Although significant associations of childhood adversities with adult mental disorders are widely documented, most studies focus on single childhood adversities predicting single disorders. Aims To examine joint associations of 12 childhood adversities with first onset of 20 DSM–IV disorders in World Mental Health (WMH) Surveys in 21 countries. Method Nationally or regionally representative surveys of 51 945 adults assessed childhood adversities and lifetime DSM–IV disorders with the WHO Composite International Diagnostic Interview (CIDI). Results Childhood adversities were highly prevalent and interrelated. Childhood adversities associated with maladaptive family functioning (e.g. parental mental illness, child abuse, neglect) were the strongest predictors of disorders. Co-occurring childhood adversities associated with maladaptive family functioning had significant subadditive predictive associations and little specificity across disorders. Childhood adversities account for 29.8% of all disorders across countries. Conclusions Childhood adversities have strong associations with all classes of disorders at all life-course stages in all groups of WMH countries. Long-term associations imply the existence of as-yet undetermined mediators.

Journal ArticleDOI
TL;DR: In this article, an almost independent constraint on the ratio of distances D-V(0.275) = 0.1390 +/- 0.0037 (2.7 per cent accuracy), where r(s) is the comoving sound horizon at the baryon-drag epoch, DV(z) equivalent to [(1 + z)D(A)(2)cz/H(z)](1/3), D-A(z), is the angular diameter distance and H(z).
Abstract: The spectroscopic Sloan Digital Sky Survey (SDSS) Data Release 7 (DR7) galaxy sample represents the final set of galaxies observed using the original SDSS target selection criteria. We analyse the clustering of galaxies within this sample, including both the luminous red galaxy and main samples, and also include the 2-degree Field Galaxy Redshift Survey data. In total, this sample comprises 893 319 galaxies over 9100 deg(2). Baryon acoustic oscillations (BAO) are observed in power spectra measured for different slices in redshift; this allows us to constrain the distance-redshift relation at multiple epochs. We achieve a distance measure at redshift z = 0.275, of r(s)(z(d))/D-V(0.275) = 0.1390 +/- 0.0037 (2.7 per cent accuracy), where r(s)(z(d)) is the comoving sound horizon at the baryon-drag epoch, D-V(z) equivalent to [(1 + z)(2)D(A)(2)cz/H(z)](1/3), D-A(z) is the angular diameter distance and H(z) is the Hubble parameter. We find an almost independent constraint on the ratio of distances D-V(0.35)/D-V(0.2) = 1.736 +/- 0.065, which is consistent at the 1.1 sigma level with the best-fitting Lambda cold dark matter model obtained when combining our z = 0.275 distance constraint with the Wilkinson Microwave Anisotropy Probe 5-year (WMAP5) data. The offset is similar to that found in previous analyses of the SDSS DR5 sample, but the discrepancy is now of lower significance, a change caused by a revised error analysis and a change in the methodology adopted, as well as the addition of more data. Using WMAP5 constraints on Omega(b)h(2) and Omega(c) h(2), and combining our BAO distance measurements with those from the Union supernova sample, places a tight constraint on Omega(m) = 0.286 +/- 0.018 and H-0 = 68.2 +/- 2.2 km s(-1) Mpc(-1) that is robust to allowing Omega(k) not equal 0 and omega not equal -1. This result is independent of the behaviour of dark energy at redshifts greater than those probed by the BAO and supernova measurements. Combining these data sets with the full WMAP5 likelihood constraints provides tight constraints on both Omega(k) = -0.006 +/- 0.008 and omega = -0.97 +/- 0.10 for a constant dark energy equation of state.

Journal ArticleDOI
TL;DR: MassBank is the first public repository of mass spectra of small chemical compounds for life sciences and provides a merged spectrum for each compound prepared by merging the analyzed ESI-MS(2) data on an identical compound under different collision-induced dissociation conditions.
Abstract: MassBank is the first public repository of mass spectra of small chemical compounds for life sciences (<3000 Da). The database contains 605 electron-ionization mass spectrometry (EI-MS), 137 fast atom bombardment MS and 9276 electrospray ionization (ESI)-MS(n) data of 2337 authentic compounds of metabolites, 11 545 EI-MS and 834 other-MS data of 10,286 volatile natural and synthetic compounds, and 3045 ESI-MS(2) data of 679 synthetic drugs contributed by 16 research groups (January 2010). ESI-MS(2) data were analyzed under nonstandardized, independent experimental conditions. MassBank is a distributed database. Each research group provides data from its own MassBank data servers distributed on the Internet. MassBank users can access either all of the MassBank data or a subset of the data by specifying one or more experimental conditions. In a spectral search to retrieve mass spectra similar to a query mass spectrum, the similarity score is calculated by a weighted cosine correlation in which weighting exponents on peak intensity and the mass-to-charge ratio are optimized to the ESI-MS(2) data. MassBank also provides a merged spectrum for each compound prepared by merging the analyzed ESI-MS(2) data on an identical compound under different collision-induced dissociation conditions. Data merging has significantly improved the precision of the identification of a chemical compound by 21-23% at a similarity score of 0.6. Thus, MassBank is useful for the identification of chemical compounds and the publication of experimental data.

Journal ArticleDOI
TL;DR: The concept of diabetes mellitus as mentioned in this paper is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action.
Abstract: Concept of Diabetes Mellitus: Diabetes mellitus is a group of diseases associated with various metabolic disorders, the main feature of which is chronic hyperglycemia due to insufficient insulin action. Its pathogenesis involves both genetic and environmental factors. The long‐term persistence of metabolic disorders can cause susceptibility to specific complications and also foster arteriosclerosis. Diabetes mellitus is associated with a broad range of clinical presentations, from being asymptomatic to ketoacidosis or coma, depending on the degree of metabolic disorder.

Journal ArticleDOI
TL;DR: Kowalski et al. as mentioned in this paper reported on work to increase the number of well-measured Type Ia supernovae (SNe Ia) at high redshifts.
Abstract: We report on work to increase the number of well-measured Type Ia supernovae (SNe Ia) at high redshifts. Light curves, including high signal-to-noise HST data, and spectra of six SNe Ia that were discovered during 2001 are presented. Additionally, for the two SNe with z > 1, we present groundbased J-band photometry from Gemini and the VLT. These are among the most distant SNe Ia for which ground based near-IR observations have been obtained. We add these six SNe Ia together with other data sets that have recently become available in the literature to the Union compilation (Kowalski et al. 2008). We have made a number of refinements to the Union analysis chain, the most important ones being the refitting of all light curves with the SALT2 fitter and an improved handling of systematic errors. We call this new compilation, consisting of 557 supernovae, the Union2

Journal ArticleDOI
21 Jan 2010-Nature
TL;DR: It is reported that water and clay, when mixed with a very small proportion of organic components, quickly form a transparent hydrogel, which can be moulded into shape-persistent, free-standing objects owing to its exceptionally great mechanical strength, and rapidly and completely self-heals when damaged.
Abstract: With the world's focus on reducing our dependency on fossil-fuel energy, the scientific community can investigate new plastic materials that are much less dependent on petroleum than are conventional plastics. Given increasing environmental issues, the idea of replacing plastics with water-based gels, so-called hydrogels, seems reasonable. Here we report that water and clay (2-3 per cent by mass), when mixed with a very small proportion (<0.4 per cent by mass) of organic components, quickly form a transparent hydrogel. This material can be moulded into shape-persistent, free-standing objects owing to its exceptionally great mechanical strength, and rapidly and completely self-heals when damaged. Furthermore, it preserves biologically active proteins for catalysis. So far no other hydrogels, including conventional ones formed by mixing polymeric cations and anions or polysaccharides and borax, have been reported to possess all these features. Notably, this material is formed only by non-covalent forces resulting from the specific design of a telechelic dendritic macromolecule with multiple adhesive termini for binding to clay.

Journal ArticleDOI
Stephen Richards1, Richard A. Gibbs1, Nicole M. Gerardo2, Nancy A. Moran3  +220 moreInstitutions (58)
TL;DR: The genome of the pea aphid shows remarkable levels of gene duplication and equally remarkable gene absences that shed light on aspects of aphid biology, most especially its symbiosis with Buchnera.
Abstract: Aphids are important agricultural pests and also biological models for studies of insect-plant interactions, symbiosis, virus vectoring, and the developmental causes of extreme phenotypic plasticity. Here we present the 464 Mb draft genome assembly of the pea aphid Acyrthosiphon pisum. This first published whole genome sequence of a basal hemimetabolous insect provides an outgroup to the multiple published genomes of holometabolous insects. Pea aphids are host-plant specialists, they can reproduce both sexually and asexually, and they have coevolved with an obligate bacterial symbiont. Here we highlight findings from whole genome analysis that may be related to these unusual biological features. These findings include discovery of extensive gene duplication in more than 2000 gene families as well as loss of evolutionarily conserved genes. Gene family expansions relative to other published genomes include genes involved in chromatin modification, miRNA synthesis, and sugar transport. Gene losses include genes central to the IMD immune pathway, selenoprotein utilization, purine salvage, and the entire urea cycle. The pea aphid genome reveals that only a limited number of genes have been acquired from bacteria; thus the reduced gene count of Buchnera does not reflect gene transfer to the host genome. The inventory of metabolic genes in the pea aphid genome suggests that there is extensive metabolite exchange between the aphid and Buchnera, including sharing of amino acid biosynthesis between the aphid and Buchnera. The pea aphid genome provides a foundation for post-genomic studies of fundamental biological questions and applied agricultural problems.

Journal ArticleDOI
TL;DR: It is demonstrated that the optical absorption of carbon nitride semiconductor materials is extendable into the visible region up to about 750 nm by simple copolymerization with organic monomers like barbituric acid (BA).
Abstract: and nonmetallic elements (N, C, B) creates localized/ delocalized states in the band gap and thus extends its optical absorption to the visible region, but doping usually comes with accelerated charge recombination and lower stability of the doped materials. Meanwhile, various other inorganic, non-TiO2-based, visible-light catalysts have been developed (e.g., metal oxides, nitrides, sulfides, phosphides, and their mixed solid solutions), whereby Ga, Ge, In, Ta, Nb, and W are the main metal constituents. However, sustained utilization of solar energy calls for the development of more abundant and stable catalysts working with visible light, and this has remained challenging so far. Recently, a polymeric semiconductor on the basis of a defecteous graphitic carbon nitride (g-C3N4), was introduced as a metal-free photocatalyst which fulfills the basic requirements for a water-splitting catalyst, including being abundant, stable, and responsive to visible light. In the following, we use the notation “g-C3N4” to describe this class of materials rather than the idealized structure. The most active system is in fact presumably an N-bridged “poly(tri-s-triazine)”, already described by Liebig as “melon”. A semiconductor structure with band edges straddling the water redox potential was revealed for melon by DFT calculations, albeit electrochemical analysis is still awaited. g-C3N4 is considered to be the most stable phase of covalent carbon nitride, and facile synthesis of the melon substructure from simple liquid precursors and monomers allows easy engineering of carbon nitride materials to achieve the desired nanostructures via soft-chemical processing routes and methods. For instance, a high surface area (67–400 mg ) can be imparted on g-C3N4 materials by polymerization of cyanamide on a silica template, which results in photocatalytically more active g-C3N4 nanostructures. [8] Metal-doped gC3N4 can also be conveniently obtained by polymerization of dicyandiamine in the presence of metal salts, and thus multifunctionalization of such materials for a variety of applications can be achieved. Most importantly, the electronic and optical properties of carbon nitride, regarded as a polymer semiconductor, are in principle adjustable by organic protocols. Such organic protocols have been widely used to control the performance of traditional p-conjugated polymers, for example, to improve solar-cell efficiencies by constructing copolymerized donor–acceptor structures, or to modify electronic properties by co-blending with p/n-type organic dopants. Our aim was to use such organic modifications to extend the insufficient light absorption of g-C3N4 (a result of its large band gap of 2.7 eV, which corresponds to wavelengths shorter than 460 nm) towards the maximum of the solar spectrum. Here we demonstrate that the optical absorption of carbon nitride semiconductor materials is extendable into the visible region up to about 750 nm by simple copolymerization with organic monomers like barbituric acid (BA). The electronic and photoelectric properties of the modified carbon nitrides were then investigated to elucidate their enhanced activity for hydrogen production from water containing an appropriate sacrificial reagent with visible light. In principle, BA can be directly incorporated into the classical carbon nitride condensation scheme (Scheme 1). New carbon nitride structures were therefore synthesized by dissolving dicyandiamide with different amounts of BA in water, followed by thermally induced copolymerization at 823 K. For simplicity, the resulting samples are denoted CNBx, where x (0.05, 0.1, 0.2, 0.5, 1, 2) refers to the weighedin amount of BA. The structure, texture, and electrochemical properties of these materials were characterized, and their photochemical performance analyzed. Their XRD patterns (Figure S1, Supporting Information) are dominated by the characteristic (002) peak at 27.48 of a graphitic, layered structure with an interlayer distance of d = [*] J. Zhang, X. Chen , Prof. X. Fu, Prof. X. Wang State Key Laboratory Breeding Base of Photocatalysis Fuzhou University, Fuzhou 350002 (China) E-mail: xcwang@fzu.edu.cn

Journal ArticleDOI
TL;DR: A new version of the atmosphere-ocean general circulation model cooperatively produced by the Japanese research community, known as the Model for Interdisciplinary Research on Climate (MIROC), has recently been developed.
Abstract: A new version of the atmosphere–ocean general circulation model cooperatively produced by the Japanese research community, known as the Model for Interdisciplinary Research on Climate (MIROC), has recently been developed. A century-long control experiment was performed using the new version (MIROC5) with the standard resolution of the T85 atmosphere and 1° ocean models. The climatological mean state and variability are then compared with observations and those in a previous version (MIROC3.2) with two different resolutions (medres, hires), coarser and finer than the resolution of MIROC5. A few aspects of the mean fields in MIROC5 are similar to or slightly worse than MIROC3.2, but otherwise the climatological features are considerably better. In particular, improvements are found in precipitation, zonal mean atmospheric fields, equatorial ocean subsurface fields, and the simulation of El Nino–Southern Oscillation. The difference between MIROC5 and the previous model is larger than that between th...

Journal ArticleDOI
TL;DR: This work demonstrates organic transistors and complementary circuits that continue to operate without degradation while being folded into a radius of 100 μm, enabled by a very thin plastic substrate, an atomically smooth planarization coating and a hybrid encapsulation stack that places the transistors in the neutral strain position.
Abstract: Flexible electronic circuits are an essential prerequisite for the development of rollable displays, conformable sensors, biodegradable electronics and other applications with unconventional form factors. The smallest radius into which a circuit can be bent is typically several millimetres, limited by strain-induced damage to the active circuit elements. Bending-induced damage can be avoided by placing the circuit elements on rigid islands connected by stretchable wires, but the presence of rigid areas within the substrate plane limits the bending radius. Here we demonstrate organic transistors and complementary circuits that continue to operate without degradation while being folded into a radius of 100 μm. This enormous flexibility and bending stability is enabled by a very thin plastic substrate (12.5 μm), an atomically smooth planarization coating and a hybrid encapsulation stack that places the transistors in the neutral strain position. We demonstrate a potential application as a catheter with a sheet of transistors and sensors wrapped around it that enables the spatially resolved measurement of physical or chemical properties inside long, narrow tubes.

Journal ArticleDOI
TL;DR: The fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar catalog as discussed by the authors contains 105,783 spectroscopically confirmed quasars, which is based upon the SDSS Seventh Data Release.
Abstract: We present the fifth edition of the Sloan Digital Sky Survey (SDSS) Quasar Catalog, which is based upon the SDSS Seventh Data Release. The catalog, which contains 105,783 spectroscopically confirmed quasars, represents the conclusion of the SDSS-I and SDSS-II quasar survey. The catalog consists of the SDSS objects that have luminosities larger than Mi = –22.0 (in a cosmology with H 0 = 70 km s–1 Mpc–1, Ω M = 0.3, and ΩΛ = 0.7), have at least one emission line with FWHM larger than 1000 km s–1 or have interesting/complex absorption features, are fainter than i 15.0, and have highly reliable redshifts. The catalog covers an area of 9380 deg2. The quasar redshifts range from 0.065 to 5.46, with a median value of 1.49; the catalog includes 1248 quasars at redshifts greater than 4, of which 56 are at redshifts greater than 5. The catalog contains 9210 quasars with i < 18; slightly over half of the entries have i < 19. For each object the catalog presents positions accurate to better than 01 rms per coordinate, five-band (ugriz) CCD-based photometry with typical accuracy of 0.03 mag, and information on the morphology and selection method. The catalog also contains radio, near-infrared, and X-ray emission properties of the quasars, when available, from other large-area surveys. The calibrated digital spectra cover the wavelength region 3800-9200 A at a spectral resolution of 2000; the spectra can be retrieved from the SDSS public database using the information provided in the catalog. Over 96% of the objects in the catalog were discovered by the SDSS. We also include a supplemental list of an additional 207 quasars with SDSS spectra whose archive photometric information is incomplete.

Journal ArticleDOI
TL;DR: In this article, the fraction of the universe going into primordial black holes in the mass range was studied and the effects of their evaporations on big bang nucleosynthesis and the extragalactic photon background were discussed.
Abstract: We update the constraints on the fraction of the Universe going into primordial black holes in the mass range ${10}^{9}--{10}^{17}\text{ }\text{ }\mathrm{g}$ associated with the effects of their evaporations on big bang nucleosynthesis and the extragalactic photon background. We include for the first time all the effects of quark and gluon emission by black holes on these constraints and account for the latest observational developments. We then discuss the other constraints in this mass range and show that these are weaker than the nucleosynthesis and photon background limits, apart from a small range ${10}^{13}--{10}^{14}\text{ }\text{ }\mathrm{g}$, where the damping of cosmic microwave background anisotropies dominates. Finally we review the gravitational and astrophysical effects of nonevaporating primordial black holes, updating constraints over the broader mass range $1--{10}^{50}\text{ }\text{ }\mathrm{g}$.

Journal ArticleDOI
TL;DR: This Review discusses how numerous cellular context-dependent factors maintain the balance of TGFβ signalling and how their collapse leads to tumour progression.
Abstract: The distortion of growth factor signalling is the most important prerequisite in tumour progression. Transforming growth factor-beta (TGFbeta) signalling regulates tumour progression by a tumour cell-autonomous mechanism or through tumour-stroma interaction, and has either a tumour-suppressing or tumour-promoting function depending on cellular context. Such inherent complexity of TGFbeta signalling results in arduous, but promising, assignments for developing therapeutic strategies against malignant tumours. As numerous cellular context-dependent factors tightly maintain the balance of TGFbeta signalling and contribute to the regulation of TGFbeta-induced cell responses, in this Review we discuss how they maintain the balance of TGFbeta signalling and how their collapse leads to tumour progression.

Journal ArticleDOI
TL;DR: This work proposes an aggregator that makes efficient use of the distributed power of electric vehicles to produce the desired grid-scale power and applies the dynamic programming algorithm to compute the optimal charging control for each vehicle.
Abstract: For vehicle-to-grid (V2G) frequency regulation services, we propose an aggregator that makes efficient use of the distributed power of electric vehicles to produce the desired grid-scale power. The cost arising from the battery charging and the revenue obtained by providing the regulation are investigated and represented mathematically. Some design considerations of the aggregator are also discussed together with practical constraints such as the energy restriction of the batteries. The cost function with constraints enables us to construct an optimization problem. Based on the developed optimization problem, we apply the dynamic programming algorithm to compute the optimal charging control for each vehicle. Finally, simulations are provided to illustrate the optimality of the proposed charging control strategy with variations of parameters.

Journal ArticleDOI
24 Nov 2010-Cell
TL;DR: These findings suggest that Sirt3-dependent mitochondrial adaptations may be a central mechanism of aging retardation in mammals and suggest that CR reduces oxidative DNA damage in multiple tissues and prevents AHL in wild-type mice but fails to modify these phenotypes in mice lacking the mitochondrial deacetylase Sirt 3.

Journal ArticleDOI
TL;DR: In this paper, the authors propose an alternate, calculable mechanism of dark matter genesis, "thermal freeze-in", involving a Feebly Interacting Massive Particle (FIMP) interacting so feebly with the thermal bath that it never attains thermal equilibrium.
Abstract: We propose an alternate, calculable mechanism of dark matter genesis, “thermal freeze-in”, involving a Feebly Interacting Massive Particle (FIMP) interacting so feebly with the thermal bath that it never attains thermal equilibrium. As with the conventional “thermal freeze-out” production mechanism, the relic abundance reflects a combination of initial thermal distributions together with particle masses and couplings that can be measured in the laboratory or astrophysically. The freeze-in yield is IR dominated by low temperatures near the FIMP mass and is independent of unknown UV physics, such as the reheat temperature after inflation. Moduli and modulinos of string theory compactifications that receive mass from weak-scale supersymmetry breaking provide implementations of the freeze-in mechanism, as do models that employ Dirac neutrino masses or GUT-scale-suppressed interactions. Experimental signals of freeze-in and FIMPs can be spectacular, including the production of new metastable coloured or charged particles at the LHC as well as the alteration of big bang nucleosynthesis.

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TL;DR: In this paper, a flow chart with standard procedures for PEC characterization techniques for planar photoelectrode materials (i.e., not suspensions of particles) with a focus on single band gap absorbers is presented.
Abstract: Photoelectrochemical (PEC) water splitting for hydrogen production is a promising technology that uses sunlight and water to produce renewable hydrogen with oxygen as a by-product. In the expanding field of PEC hydrogen production, the use of standardized screening methods and reporting has emerged as a necessity. This article is intended to provide guidance on key practices in characterization of PEC materials and proper reporting of efficiencies. Presented here are the definitions of various efficiency values that pertain to PEC, with an emphasis on the importance of solar-to-hydrogen efficiency, as well as a flow chart with standard procedures for PEC characterization techniques for planar photoelectrode materials (i.e., not suspensions of particles) with a focus on single band gap absorbers. These guidelines serve as a foundation and prelude to a much more complete and in-depth discussion of PEC techniques and procedures presented elsewhere.

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TL;DR: Results show that Jmjd3-mediated H3K27 demethylation is crucial for regulating M2 macrophage development leading to anti-helminth host responses.
Abstract: Polarization of macrophages to M1 or M2 cells is important for mounting responses against bacterial and helminth infections, respectively. Jumonji domain containing-3 (Jmjd3), a histone 3 Lys27 (H3K27) demethylase, has been implicated in the activation of macrophages. Here we show that Jmjd3 is essential for M2 macrophage polarization in response to helminth infection and chitin, though Jmjd3 is dispensable for M1 responses. Furthermore, Jmjd3 (also known as Kdm6b) is essential for proper bone marrow macrophage differentiation, and this function depends on demethylase activity of Jmjd3. Jmjd3 deficiency affected trimethylation of H3K27 in only a limited number of genes. Among them, we identified Irf4 as encoding a key transcription factor that controls M2 macrophage polarization. Collectively, these results show that Jmjd3-mediated H3K27 demethylation is crucial for regulating M2 macrophage development leading to anti-helminth host responses.

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18 Nov 2010-Neuron
TL;DR: Recent studies have begun to clarify the mechanisms of cargo selection and directional transport in subcellular compartments and molecular genetics has revealed unexpected roles for molecular motors in brain wiring, neuronal survival, neuronal plasticity, higher brain function, and control of central nervous system and peripheral nervous system development.