University of Tokyo

About: University of Tokyo is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 134564 authors who have published 337567 publications receiving 10178620 citations. The organization is also known as: Todai & Universitas Tociensis.

Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids

Abstract: Genome editing applied to human intestinal organoids enables the study of the functional effects of mutations recurrent in human tumors.

Interferometer design of the KAGRA gravitational wave detector

Abstract: KAGRA is a cryogenic interferometric gravitational-wave detector being constructed at the underground site of Kamioka mine in Gifu prefecture, Japan. We performed an optimization of the interferomter design, to achieve the best sensitivity and a stable operation, with boundary conditions of classical noises and under various practical constraints, such as the size of the tunnel or the mirror cooling capacity. Length and alignment sensing schemes for the robust control of the interferometer are developed. In this paper, we describe the detailed design of the KAGRA interferometer as well as the reasoning behind design choices.

Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI

Abstract: Inhibition of an ongoing reaction tendency for adaptation to changing environments is a major function of the human prefrontal cortex. This function has been investigated frequently using the go/no-go task and set-shifting tasks such as the Wisconsin Card Sorting Test (WCST). Studies in humans and monkeys suggest the involvement of the dorsolateral prefrontal cortex in the two task paradigms. However, it remains unknown where in the dorsolateral prefrontal cortex this function is localized, whether a common inhibitory mechanism is used in these task paradigms and how this inhibitory function acts on two different targets, i.e. the go response in the go/no-go task and the cognitive set in the WCST. In the go/no-go task of this study, subjects were instructed to either respond (go trial) or not respond (no-go trial), depending on the cue stimulus presented. The signals of functional MRI (fMRI) related to the inhibitory function should be transient by nature. Thus, we used the temporal resolution of fMRI (event-related fMRI) by which transient signals in go and no-go trials can be analysed separately and compared with each other. We found a focus that showed transient no-go dominant activity in the posterior part of the inferior frontal sulcus in the right hemisphere. This was true irrespective of whether the subjects used their right or left hands. These results suggest that the transient activation in the right inferior prefrontal area is related to the neural mechanism underlying the response inhibition function. Furthermore, this area was found to be overlapped spatially with the area that was activated transiently during cognitive set shifting in the WCST. The transient signals in the go/no-go task peaked 5 s after the transient expression of the inhibitory function, and the transient signals in the WCST peaked 7s after the transient expression, reflecting different durations of neuronal activity in the two inhibitory task paradigms. These results imply that the right inferior prefrontal area is commonly involved in the inhibition of different targets, i.e. the go response during performance of the go/no-go task and the cognitive set during performance of the WCST.

The infrared astronomical mission AKARI

Abstract: AKARI, the first Japanese satellite dedicated to infrared astronomy, was launched on 2006 February 21, and started observations in May of the same year. AKARI has a 68.5 cm cooled telescope, together with two focal-plane instruments, which survey the sky in six wavelength bands from mid- to far-infrared. The instruments also have a capability for imaging and spectroscopy in the wavelength range 2-180 mu m in the pointed observation mode, occasionally inserted into a continuous survey operation. The in-orbit cryogen lifetime is expected to be one and a half years. The All-Sky Survey will cover more than 90% of the whole sky with a higher spatial resolution and a wider wavelength coverage than that of the previous IRAS all-sky survey. Point-source catalogues of the All-Sky Survey will be released to the astronomical community. Pointed observations will be used for deep surveys of selected sky areas and systematic observations of important astronomical targets. These will become an additional future heritage of this mission.