Institution
University of Tokyo
Education•Tokyo, Japan•
About: University of Tokyo is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 134564 authors who have published 337567 publications receiving 10178620 citations. The organization is also known as: Todai & Universitas Tociensis.
Topics: Population, Gene, Catalysis, Magnetic field, Galaxy
Papers published on a yearly basis
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TL;DR: In this paper, a large variety of experiments reviewed in detail here contain results compatible with the theoretical predictions, including phase diagrams of manganite models, the stabilization of the charge/orbital/spin ordered half-doped correlated electronics (CE)-states, the importance of the naively small Heisenberg coupling among localized spins, the setup of accurate mean-field approximations, and the existence of a new temperature scale T∗ where clusters start forming above the Curie temperature, the presence of stripes in the system, and many others.
2,927 citations
Jeffrey D. Stanaway1, Ashkan Afshin1, Emmanuela Gakidou1, Stephen S Lim1 +1050 more•Institutions (346)
TL;DR: This study estimated levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs) by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017 and explored the relationship between development and risk exposure.
2,910 citations
University of California, San Francisco1, Food and Drug Administration2, University of North Carolina at Chapel Hill3, Merck & Co.4, Abbott Laboratories5, Eli Lilly and Company6, Novartis7, German Cancer Research Center8, University of Western Ontario9, Pfizer10, University of Helsinki11, GlaxoSmithKline12, University of Tokyo13, University of Maryland, Baltimore14, Genentech15, University of Arizona16
TL;DR: Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions, as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.
Abstract: Membrane transporters can be major determinants of the pharmacokinetic, safety and efficacy profiles of drugs. This presents several key questions for drug development, including which transporters are clinically important in drug absorption and disposition, and which in vitro methods are suitable for studying drug interactions with these transporters. In addition, what criteria should trigger follow-up clinical studies, and which clinical studies should be conducted if needed. In this article, we provide the recommendations of the International Transporter Consortium on these issues, and present decision trees that are intended to help guide clinical studies on the currently recognized most important drug transporter interactions. The recommendations are generally intended to support clinical development and filing of a new drug application. Overall, it is advised that the timing of transporter investigations should be driven by efficacy, safety and clinical trial enrolment questions (for example, exclusion and inclusion criteria), as well as a need for further understanding of the absorption, distribution, metabolism and excretion properties of the drug molecule, and information required for drug labelling.
2,879 citations
TL;DR: These changes in CA1, called here 'delayed neuronal death', may differ from those thought to be typical of ischemic neuronal damage, and it is unlikely that the disturbance of local blood vessels was the cause of these changes.
2,872 citations
TL;DR: Progress in the biochemistry of microorganisms have revealed that cell-component analysis can be effectively applied to bacterial systematics, providing the basis of chemotaxonomy, and DNA homology data contribute to the clarification, not only of the relatedness of two organisms, but also of the evaluation of phenotypic characteristics.
Abstract: Publisher Summary Recent advances in the biochemistry of microorganisms have revealed that cell-component analysis can be effectively applied to bacterial systematics, providing the basis of chemotaxonomy. Analyses of cell components are coming to be essential tools not only for bacterial classification but also for identification. The sequence of chromosomal DNA holds the essential genetic information for an organism. Phylogenetic relationships are often examined using data on nucleotide sequences of ribosomal RNA. However, it is still impossible to determine the sequences of large polynucleotides for the number of organisms sufficient for taxonomic purposes. DNA (RNA) homologies, which have been applied to various kinds of bacteria, present useful information on bacterial systematics. Homology indices are values used in comparing microorganisms. DNA homology data contribute to the clarification, not only of the relatedness of two organisms, but also of the evaluation of phenotypic characteristics.
2,862 citations
Authors
Showing all 135252 results
| Name | H-index | Papers | Citations |
|---|---|---|---|
| Ronald C. Kessler | 274 | 1332 | 328983 |
| Donald P. Schneider | 242 | 1622 | 263641 |
| George M. Whitesides | 240 | 1739 | 269833 |
| Jing Wang | 184 | 4046 | 202769 |
| Tadamitsu Kishimoto | 181 | 1067 | 130860 |
| Yusuke Nakamura | 179 | 2076 | 160313 |
| Dennis J. Selkoe | 177 | 607 | 145825 |
| David L. Kaplan | 177 | 1944 | 146082 |
| D. M. Strom | 176 | 3167 | 194314 |
| Masayuki Yamamoto | 171 | 1576 | 123028 |
| Krzysztof Matyjaszewski | 169 | 1431 | 128585 |
| Yang Yang | 164 | 2704 | 144071 |
| Qiang Zhang | 161 | 1137 | 100950 |
| Kenji Kangawa | 153 | 1117 | 110059 |
| Takashi Taniguchi | 152 | 2141 | 110658 |