University of Tokyo

About: University of Tokyo is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 134564 authors who have published 337567 publications receiving 10178620 citations. The organization is also known as: Todai & Universitas Tociensis.

Stereotactic Radiosurgery Plus Whole-Brain Radiation Therapy vs Stereotactic Radiosurgery Alone for Treatment of Brain Metastases: A Randomized Controlled Trial

Abstract: ContextIn patients with brain metastases, it is unclear whether adding up-front whole-brain radiation therapy (WBRT) to stereotactic radiosurgery (SRS) has beneficial effects on mortality or neurologic function compared with SRS alone.ObjectiveTo determine if WBRT combined with SRS results in improvements in survival, brain tumor control, functional preservation rate, and frequency of neurologic death.Design, Setting, and PatientsRandomized controlled trial of 132 patients with 1 to 4 brain metastases, each less than 3 cm in diameter, enrolled at 11 hospitals in Japan between October 1999 and December 2003.InterventionsPatients were randomly assigned to receive WBRT plus SRS (65 patients) or SRS alone (67 patients).Main Outcome MeasuresThe primary end point was overall survival; secondary end points were brain tumor recurrence, salvage brain treatment, functional preservation, toxic effects of radiation, and cause of death.ResultsThe median survival time and the 1-year actuarial survival rate were 7.5 months and 38.5% (95% confidence interval, 26.7%-50.3%) in the WBRT + SRS group and 8.0 months and 28.4% (95% confidence interval, 17.6%-39.2%) for SRS alone (P = .42). The 12-month brain tumor recurrence rate was 46.8% in the WBRT + SRS group and 76.4% for SRS alone group (P<.001). Salvage brain treatment was less frequently required in the WBRT + SRS group (n = 10) than with SRS alone (n = 29) (P<.001). Death was attributed to neurologic causes in 22.8% of patients in the WBRT + SRS group and in 19.3% of those treated with SRS alone (P = .64). There were no significant differences in systemic and neurologic functional preservation and toxic effects of radiation.ConclusionsCompared with SRS alone, the use of WBRT plus SRS did not improve survival for patients with 1 to 4 brain metastases, but intracranial relapse occurred considerably more frequently in those who did not receive WBRT. Consequently, salvage treatment is frequently required when up-front WBRT is not used.Trial Registrationumin.ac.jp/ctr Identifier: C000000412

Improved cosmological constraints from a joint analysis of the SDSS-II and SNLS supernova samples

Abstract: Aims. We present cosmological constraints from a joint analysis of type Ia supernova (SN Ia) observations obtained by the SDSS-II and SNLS collaborations. The dataset includes several low-redshift samples (z< 0.1), all three seasons from the SDSS-II (0.05

Spectroscopic Target Selection in the Sloan Digital Sky Survey: The Main Galaxy Sample

Abstract: We describe the algorithm that selects the main sample of galaxies for spectroscopy in the Sloan Digital Sky Survey (SDSS) from the photometric data obtained by the imaging survey. Galaxy photometric properties are measured using the Petrosian magnitude system, which measures flux in apertures determined by the shape of the surface brightness profile. The metric aperture used is essentially independent of cosmological surface brightness dimming, foreground extinction, sky brightness, and the galaxy central surface brightness. The main galaxy sample consists of galaxies with r-band Petrosian magnitudes r ≤ 17.77 and r-band Petrosian half-light surface brightnesses μ50 ≤ 24.5 mag arcsec-2. These cuts select about 90 galaxy targets per square degree, with a median redshift of 0.104. We carry out a number of tests to show that (1) our star-galaxy separation criterion is effective at eliminating nearly all stellar contamination while removing almost no genuine galaxies, (2) the fraction of galaxies eliminated by our surface brightness cut is very small (~0.1%), (3) the completeness of the sample is high, exceeding 99%, and (4) the reproducibility of target selection based on repeated imaging scans is consistent with the expected random photometric errors. The main cause of incompleteness is blending with saturated stars, which becomes more significant for brighter, larger galaxies. The SDSS spectra are of high enough signal-to-noise ratio (S/N > 4 per pixel) that essentially all targeted galaxies (99.9%) yield a reliable redshift (i.e., with statistical error less than 30 km s-1). About 6% of galaxies that satisfy the selection criteria are not observed because they have a companion closer than the 55'' minimum separation of spectroscopic fibers, but these galaxies can be accounted for in statistical analyses of clustering or galaxy properties. The uniformity and completeness of the galaxy sample make it ideal for studies of large-scale structure and the characteristics of the galaxy population in the local universe.