University of Tokyo

About: University of Tokyo is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 134564 authors who have published 337567 publications receiving 10178620 citations. The organization is also known as: Todai & Universitas Tociensis.

Maximum Classifier Discrepancy for Unsupervised Domain Adaptation

Abstract: In this work, we present a method for unsupervised domain adaptation. Many adversarial learning methods train domain classifier networks to distinguish the features as either a source or target and train a feature generator network to mimic the discriminator. Two problems exist with these methods. First, the domain classifier only tries to distinguish the features as a source or target and thus does not consider task-specific decision boundaries between classes. Therefore, a trained generator can generate ambiguous features near class boundaries. Second, these methods aim to completely match the feature distributions between different domains, which is difficult because of each domain's characteristics. To solve these problems, we introduce a new approach that attempts to align distributions of source and target by utilizing the task-specific decision boundaries. We propose to maximize the discrepancy between two classifiers' outputs to detect target samples that are far from the support of the source. A feature generator learns to generate target features near the support to minimize the discrepancy. Our method outperforms other methods on several datasets of image classification and semantic segmentation. The codes are available at https://github.com/mil-tokyo/MCD_DA

Photoinduced Magnetization of a Cobalt-Iron Cyanide

Abstract: Photoinduced magnetization was observed in a Prussian blue analog, K0.2Co1.4- [Fe(CN)6]·6.9H2O. An increase in the critical temperature from 16 to 19 kelvin was observed as a result of red light illumination. Moreover, the magnetization in the ferrimagnetic region below 16 kelvin was substantially increased after illumination and could be restored almost to its original level by thermal treatment. These effects are thought to be caused by an internal photochemical redox reaction. Furthermore, blue light illumination could be used to partly remove the enhancement of the magnetization. Such control over magnetic properties by optical stimuli may have application in magneto-optical devices.

Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson's disease and dementia with Lewy bodies.

Abstract: Lewy bodies (LBs) are hallmark lesions of degenerating neurons in the brains of patients with Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Recently, a point mutation in the gene encoding the presynaptic alpha-synuclein protein was identified in some autosomal-dominantly inherited familial PD pedigrees, and light microscopic studies demonstrated alpha-synuclein immunoreactivity in LBs of sporadic PD and DLB. To characterize alpha-synuclein in LBs, we raised monoclonal antibodies (MAbs) to LBs purified from DLB brains and obtained a MAb specific for alpha-synuclein that intensely labeled LBs. Light and electron microscopic immunocytochemical studies performed with this MAb as well as other antibodies to alpha-and beta-synuclein showed that alpha-synuclein, but not beta-synuclein, is a component of LBs in sporadic PD and DLB. Western blot analyses of highly purified LBs from DLB brains showed that full-length as well as partially truncated and insoluble aggregates of alpha-synuclein are deposited in LBs. Thus, these data strongly implicate alpha-synuclein in the formation of LBs and the selective degeneration of neurons in sporadic PD and DLB.