University of Tokyo

About: University of Tokyo is a education organization based out in Tokyo, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 134564 authors who have published 337567 publications receiving 10178620 citations. The organization is also known as: Todai & Universitas Tociensis.

The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)

Abstract: The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009)

APHRODITE: Constructing a Long-Term Daily Gridded Precipitation Dataset for Asia Based on a Dense Network of Rain Gauges

Abstract: A daily gridded precipitation dataset covering a period of more than 57 yr was created by collecting and analyzing rain gauge observation data across Asia through the activities of the Asian Precipitation—Highly Resolved Observational Data Integration Towards Evaluation of Water Resources (APHRODITE) project. APHRODITE's daily gridded precipitation is presently the only long-term, continental-scale, high-resolution daily product. The product is based on data collected at 5,000–12,000 stations, which represent 2.3–4.5 times the data made available through the Global Telecommunication System network and is used for most daily gridded precipitation products. Hence, the APHRODITE project has substantially improved the depiction of the areal distribution and variability of precipitation around the Himalayas, Southeast Asia, and mountainous regions of the Middle East. The APHRODITE project now contributes to studies such as the determination of Asian monsoon precipitation change, evaluation of water resources, ...

The DNA sequence of human chromosome 21

Abstract: Chromosome 21 is the smallest human autosome. An extra copy of chromosome 21 causes Down syndrome, the most frequent genetic cause of significant mental retardation, which affects up to 1 in 700 live births. Several anonymous loci for monogenic disorders and predispositions for common complex disorders have also been mapped to this chromosome, and loss of heterozygosity has been observed in regions associated with solid tumours. Here we report the sequence and gene catalogue of the long arm of chromosome 21. We have sequenced 33,546,361 base pairs (bp) of DNA with very high accuracy, the largest contig being 25,491,867 bp. Only three small clone gaps and seven sequencing gaps remain, comprising about 100 kilobases. Thus, we achieved 99.7% coverage of 21q. We also sequenced 281,116 bp from the short arm. The structural features identified include duplications that are probably involved in chromosomal abnormalities and repeat structures in the telomeric and pericentromeric regions. Analysis of the chromosome revealed 127 known genes, 98 predicted genes and 59 pseudogenes.

A superconducting copper oxide compound with electrons as the charge carriers

Abstract: Since the discovery of high-temperature superconductivity in cop-per oxide compounds1, there has been much effort to understand what is required for a compound to have a high transition tem-perature (Tc). Up to now, all of the families of high-Tc copper oxide superconductors have contained two-dimensional sheets of Cu–O pyramids or octahedra, and the carriers of the superconduct-ing current have been electron vacancies, or 'holes'. By contrast, we report here the discovery of a family of superconducting copper oxides in which the carriers are electrons. The new superconductors are Ce4+-doped compounds, with the formula Ln2–xCexCuO4–y, where Ln stands for the lanthanides Pr, Nd or Sm. The compounds have the Nd2CuO4 (T′-phase) structure2, which is composed of sheets of Cu–O squares (see Fig. la). This structure has no apical oxygen atoms, in contrast to the T-phase structure with Cu–O octahedra (Fig. 1b), as observed in La2–xSrxCuO4 (refs 1, 2), and the T*-phase structure with Cu–O pyramids (Fig. 1c), as in Nd2–x–z Cex Srz CuO4 (ref. 3 and Y. T. et al., manuscript in preparation).

Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update

Abstract: There is great geographical variation in the distribution of hepatocellular carcinoma (HCC), with the majority of all cases worldwide found in the Asia–Pacific region, where HCC is one of the leading public health problems. Since the “Toward Revision of the Asian Pacific Association for the Study of the Liver (APASL) HCC Guidelines” meeting held at the 25th annual conference of the APASL in Tokyo, the newest guidelines for the treatment of HCC published by the APASL has been discussed. This latest guidelines recommend evidence-based management of HCC and are considered suitable for universal use in the Asia–Pacific region, which has a diversity of medical environments.