University of Trento

About: University of Trento is a education organization based out in Trento, Italy. It is known for research contribution in the topics: Population & Large Hadron Collider. The organization has 10527 authors who have published 30978 publications receiving 896614 citations. The organization is also known as: Universitá degli Studi di Trento & Universita degli Studi di Trento.

A new class of random vector entropy estimators and its applications in testing statistical hypotheses

Abstract: This paper proposes a new class of estimators of an unknown entropy of random vector Its asymptotic unbiasedness and consistency are proved Further, this class of estimators is used to build both goodness-of-fit and independence tests based on sample entropy A simulation study indicates that the test involving the proposed entropy estimate has higher power than other well-known competitors under heavy tailed alternatives which are frequently used in many financial applications

Gene Expression Elucidates Functional Impact of Polygenic Risk for Schizophrenia

Abstract: Over 100 genetic loci harbor schizophrenia associated variants, yet how these common variants confer risk is uncertain. The CommonMind Consortium has sequenced dorsolateral prefrontal cortex RNA from schizophrenia cases (n=258) and control subjects (n=279), creating the largest publicly available resource to date of gene expression and its genetic regulation; ~5 times larger than the latest release of GTEx. Using this resource, we find that ~20% of the schizophrenia risk loci have common variants that could explain regulation of brain gene expression. In five loci, these variants modulate expression of a single gene: FURIN, TSNARE1, CNTN4, CLCN3 or SNAP91. Experimentally altered expression of three of them, FURIN, TSNARE1, and CNTN4, perturbs the proliferation and apoptotic index of neural progenitors and leads to neuroanatomical deficits in zebrafish. Furthermore, shRNA mediated knock-down of FURIN in neural progenitor cells derived from human induced pluripotent stem cells produces abnormal neural migration. Although 4.2% of genes (N = 693) display significant differential expression between cases and controls, 44% show some evidence for differential expression. All fold changes are ≤ 1.33, and an independent cohort yields similar differential expression for these 693 genes (r = 0.58). These findings are consistent with schizophrenia being highly polygenic, as has been reported in investigations of common and rare genetic variation. Co-expression analyses identify a gene module that shows enrichment for genetic associations and is thus relevant for schizophrenia. Taken together, these results pave the way for mechanistic interpretations of genetic liability for schizophrenia and other brain diseases.

Training Adversarial Discriminators for Cross-Channel Abnormal Event Detection in Crowds

Abstract: Abnormal crowd behaviour detection attracts a large interest due to its importance in video surveillance scenarios. However, the ambiguity and the lack of sufficient abnormal ground truth data makes end-to-end training of large deep networks hard in this domain. In this paper we propose to use Generative Adversarial Nets (GANs), which are trained to generate only the normal distribution of the data. During the adversarial GAN training, a discriminator (D) is used as a supervisor for the generator network (G) and vice versa. At testing time we use D to solve our discriminative task (abnormality detection), where D has been trained without the need of manually-annotated abnormal data. Moreover, in order to prevent G learn a trivial identity function, we use a cross-channel approach, forcing G to transform raw-pixel data in motion information and vice versa. The quantitative results on standard benchmarks show that our method outperforms previous state-of-the-art methods in both the frame-level and the pixel-level evaluation.