University of Tsukuba

About: University of Tsukuba is a education organization based out in Tsukuba, Ibaraki, Japan. It is known for research contribution in the topics: Population & Gene. The organization has 36352 authors who have published 79483 publications receiving 1934752 citations. The organization is also known as: Tsukuba daigaku & Tsukuba University.

MORPHOLOGIES OF ∼190,000 GALAXIES AT z = 0–10 REVEALED WITH HST LEGACY DATA. I. SIZE EVOLUTION

Abstract: We present redshift evolution of galaxy effective radius r_e obtained from the HST samples of ~190,000 galaxies at z=0-10. Our HST samples consist of 176,152 photo-z galaxies at z=0-6 from the 3D-HST+CANDELS catalogue and 10,454 LBGs at z=4-10 identified in CANDELS, HUDF09/12, and HFF parallel fields, providing the largest data set to date for galaxy size evolution studies. We derive r_e with the same technique over the wide-redshift range of z=0-10, evaluating the optical-to-UV morphological K-correction and the selection bias of photo-z galaxies+LBGs as well as the cosmological surface brightness dimming effect. We find that r_e values at a given luminosity significantly decrease towards high-z, regardless of statistics choices. For star-forming galaxies, there is no evolution of the power-law slope of the size-luminosity relation and the median Sersic index (n~1.5). Moreover, the r_e-distribution is well represented by log-normal functions whose standard deviation \sigma_{\ln{r_e}} does not show significant evolution within the range of \sigma_{\ln{r_e}}~0.45-0.75. We calculate the stellar-to-halo size ratio from our r_e measurements and the dark-matter halo masses estimated from the abundance matching study, and obtain a nearly constant value of r_e/r_vir=1.0-3.5% at z=0-8. The combination of the r_e-distribution shape+standard deviation, the constant r_e/r_vir, and n~1.5 suggests a picture that typical high-z star-forming galaxies have disk-like stellar components in a sense of dynamics and morphology over cosmic time of z~0-6. If high-z star-forming galaxies are truly dominated by disks, the r_e/r_vir value and the disk formation model indicate that the specific angular momentum of the disk normalized by the host halo is j_d/m_d=0.5-1. These are statistical results for galaxies' major stellar components, and the detailed study of clumpy sub-components is presented in the paper II.

Homeostatic regulation of intestinal epithelia by intraepithelial gamma delta T cells

Abstract: Although T cells bearing gamma delta T-cell receptors have long been known to be present in the epithelial lining of many organs, their specificity and function remain elusive. In the present study, we examined the intestinal epithelia of T-cell-receptor mutant mice, which were deficient in either gamma delta T cells or alpha beta T cells, and of normal littermates. The absence of gamma delta T cells was associated with a reduction in epithelial cell turnover and a downregulation of the expression of major histocompatibility complex class II molecules. No such effects were observed in alpha beta T-cell-deficient mice. These findings indicate that intraepithelial gamma delta T cells regulate the generation and differentiation of intestinal epithelial cells.

Integrative Annotation of 21,037 Human Genes Validated by Full-Length cDNA Clones

Abstract: The human genome sequence defines our inherent biological potential; the realization of the biology encoded therein requires knowledge of the function of each gene. Currently, our knowledge in this area is still limited. Several lines of investigation have been used to elucidate the structure and function of the genes in the human genome. Even so, gene prediction remains a difficult task, as the varieties of transcripts of a gene may vary to a great extent. We thus performed an exhaustive integrative characterization of 41,118 full-length cDNAs that capture the gene transcripts as complete functional cassettes, providing an unequivocal report of structural and functional diversity at the gene level. Our international collaboration has validated 21,037 human gene candidates by analysis of high-quality full-length cDNA clones through curation using unified criteria. This led to the identification of 5,155 new gene candidates. It also manifested the most reliable way to control the quality of the cDNA clones. We have developed a human gene database, called the H-Invitational Database (H-InvDB; http://www.h-invitational.jp/). It provides the following: integrative annotation of human genes, description of gene structures, details of novel alternative splicing isoforms, non-protein-coding RNAs, functional domains, subcellular localizations, metabolic pathways, predictions of protein three-dimensional structure, mapping of known single nucleotide polymorphisms (SNPs), identification of polymorphic microsatellite repeats within human genes, and comparative results with mouse full-length cDNAs. The H-InvDB analysis has shown that up to 4% of the human genome sequence (National Center for Biotechnology Information build 34 assembly) may contain misassembled or missing regions. We found that 6.5% of the human gene candidates (1,377 loci) did not have a good protein-coding open reading frame, of which 296 loci are strong candidates for non-protein-coding RNA genes. In addition, among 72,027 uniquely mapped SNPs and insertions/deletions localized within human genes, 13,215 nonsynonymous SNPs, 315 nonsense SNPs, and 452 indels occurred in coding regions. Together with 25 polymorphic microsatellite repeats present in coding regions, they may alter protein structure, causing phenotypic effects or resulting in disease. The H-InvDB platform represents a substantial contribution to resources needed for the exploration of human biology and pathology.